Hypertrophic Cardiomyopathy

New England Journal of Medicine

Volumn 316, Issue 13, 1987, Pages 780-789

  Maron, Barry J ^a   Bonow, Robert O ^a   Cannon, Richard O ^a   Leon, Martin B ^a   Epstein, Stephen E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; ETIOLOGY; HEART; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; THERAPY;

CARDIOMYOPATHY, HYPERTROPHIC; HUMANS;

EID: 0023130164     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198703263161305     Document Type: Review

References (147)

1. Brock R. Functional obstruction of the left ventricle (acquired aortic subvalvular stenosis). Guy's Hosp Rep 1957; 106: 221–38.
2. Teare D. Asymmetrical hypertrophy of the heart in young adults. Br Heart J 1958; 20: 1–8.
3. Bercu BA, Diettert GA, Danforth WH, Pund EE Jr, Ahlvin RC, Belliveau RR. Pseudoaortic stenosis produced by ventricular hypertrophy. Am J Med 1958; 25: 814–8.
4. Goodwin JF, Hollman A, Cleland WP, Teare D. Obstructive cardiomyopathy simulating aortic stenosis. Br Heart J 1960; 22: 403–14.
5. Morrow AG, Braunwald E. Functional aortic stenosis: a malformation characterized by resistance to left ventricular outflow without anatomic obstruction. Circulation 1959; 20: 181–9.
6. Wigle ED, Heimbecker RO, Gunton RW. Idiopathic ventricular septal hypertrophy causing muscular subaortic stenosis. Circulation 1962; 26: 325–40.
7. Braunwald E, Lambrew CT, Rockoff SD, Ross J Jr, Morrow AG. Idiopathic hypertrophic subaortic stenosis: I. A description of the disease based upon an analysis of 64 patients. Circulation 1964; 30: Suppl 4: IV-3–IV-119.
8. Simon AL, Ross J Jr. Gault JH. Angiographic anatomy of the left ventricle and mitral valve in idiopathic hypertrophic subaortic stenosis. Circulation 1967; 36: 852–67.
9. Frank S, Braunwald E. Idiopathic hypertrophic subaortic stenosis: clinical analysis of 126 patients with emphasis on the natural history. Circulation 1968; 37: 759–88.
10. Goodwin JF. Congestive and hypertrophic cardiomyopathies: a decade of study. Lancet 1970; 1: 731–9.
11. Adelman AG, Wigle ED, Ranganathan N, et al. The clinical course in muscular subaortic stenosis: a retrospective and prospective study of 60 hemodynamically proved cases. Ann Intern Med 1972; 77: 515–25.
12. Epstein SE, Henry WL, Clark CE, et al. Asymmetric septal hypertrophy. Ann Intern Med 1974; 81: 650–80.
13. Shah PM, Adelman AG, Wigle ED, et al. The natural (and unnatural) history of hypertrophic obstructive cardiomyopathy. Circ Res 1973; 34 and 35:Suppl 2: 11–179–II-195.
14. Maron BJ, Henry WL, Clark CE, Redwood DR, Roberts WC, Epstein SE. Asymmetric septal hypertrophy in childhood. Circulation 1976; 53: 9–19.
15. McKenna W, Deanfield J, Faruqui A, England D, Oakley C, Goodwin J. Prognosis in hypertrophic cardiomyopathy: role of age and clinical, electrocardiographic and hemodynamic features. Am J Cardiol 1981; 47: 532–8.
16. Koga Y, Itaya K-i, Toshima H. Prognosis in hypertrophic cardiomyopathy. Am Heart J 1984; 108: 351–9.
17. Wigle ED, Sasson Z, Henderson MA, et al. Hypertrophic cardiomyopathy: the importance of the site and the extent of hypertrophy: a review. Prog Cardiovasc Dis 1985; 28: 1–83.
18. Maron BJ, Epstein SE. Hypertrophic cardiomyopathy: a discussion of nomenclature. Am J Cardiol 1979; 43: 1242–4.
19. Maron BJ, Gottdiener JS, Epstein SE. Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a wide angle, two dimensional echocardiographic study of 125 patients. Am J Cardiol 1981; 48: 418–28.
20. Louie EK, Maron BJ. Hypertrophic cardiomyopathy with extreme increase in left ventricular wall thickness: functional and morphologic features and clinical significance. J Am Coll Cardiol 1986; 8: 57–65.
21. Menges H Jr, Brandenburg RO, Brown AL Jr. The clinical, hemodynamic, and pathologic diagnosis of muscular subvalvular aortic stenosis. Circulation 1961; 24: 1126–36.
22. Abbasi AS, MacAlpin RN, Eber LM, Pearce ML. Echocardiographic diagnosis of idiopathic hypertrophic cardiomyopathy without outflow obstruction. Circulation 1972; 46: 897–904.
23. Henry WL, Clark CE, Epstein SE. Asymmetric septal hypertrophy: echocardiographic identification of the pathognomonic anatomic abnormality of IHSS. Circulation 1973; 47: 225–33.
24. Martin RP, Rakowski H, French J, Popp RL. Idiopathic hypertrophic subaortic stenosis viewed by wide-angle, phased-array echocardiography. Circulation 1979; 59: 1206–17.
25. Gilbert BW, Pollick C, Adelman AG, Wigle ED. Hypertrophic cardiomyopathy: subclassification by M mode echocardiography. Am J Cardiol 1980; 45: 861–72.
26. Maron BJ, Gottdiener JS, Bonow RO, Epstein SE. Hypertrophic cardiomyopathy with unusual location of left ventricular hypertrophy undetectable by M-mode echocardiography: identification by wide-angle two-dimensional echocardiography. Circulation 1981; 63: 409–18.
27. Ciró E, Nichols PF III, Maron BJ. Heterogeneous morphologic expression of genetically transmitted hypertrophic cardiomyopathy: two-dimensional echocardiographic analysis. Circulation 1983; 67: 1227–33.
28. Shapiro LM, McKenna WJ. Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a two-dimensional echocardiographic study. J Am Coll Cardiol 1983; 2: 437–44.
29. Suzuki Y, Kadota K, Nohara R, et al. Recognition of regional hypertrophy in hypertrophic cardiomyopathy using thallium-201 emission-computed tomography: comparison with two-dimensional echocardiography. Am J Cardiol 1984; 53: 1095–102.
30. Maron BJ, Spirito P, Chiarella F, Vecchio C. Unusual distribution of left ventricular hypertrophy in obstructive hypertrophic cardiomyopathy: localized posterobasal free wall thickening in two patients. J Am Coll Cardiol 1985; 5: 1474–7.
31. Maron BJ. Asymmetry in hypertrophic cardiomyopathy: the septal to free wall thickness ratio revisited. Am J Cardiol 1985; 55: 835–8.
32. Olsen EG. Anatomic and light microscopic characterisation of hypertrophie obstructive and non-obstructive cardiomyopathy. Eur Heart J 1983; 4: Suppl F: 1–8.
33. Roberts WC, Ferrans VJ. Pathologic anatomy of the cardiomyopathies: idiopathic dilated and hypertrophic types, infiltrative types, and endomyocardial disease with and without eosinophilia. Hum Pathol 1975; 6: 287–342.
34. Maron BJ, Roberts WC. Cardiomyopathies in the first two decades of life. Cardiovasc Clin 1981; 11: 35–78.
35. Maron BJ. Echocardiographic assessment of left ventricular hypertrophy in patients with obstructive or nonobstructive hypertrophic cardiomyopathy. Eur Heart J 1983; 4: Suppl F: 73–91.
36. Spirito P, Maron BJ. Bonow RO, Epstein SE. Severe functional limitation in patients with hypertrophic cardiomyopathy and only mild localized left ventricular hypertrophy. J Am Coll Cardiol 1986; 8: 537–44.
37. Maron BJ. Structural features of the athlete heart as defined by echocardiography. J Am Coll Cardiol 1986; 7: 190–203.
38. Sakamoto T, Tei C, Murayama M, et al. Giant T wave inversion as a manifestation of asymmetrical apical hypertrophy (AAH) of the left ventricle: echocardiographic and ultrasono-cardiotomographic study. Jpn Heart J 1976; 17: 611–29.
39. Yamaguchi H, Ishimura T, Nishiyama S, et al. Hypertrophic nonobstructive cardiomyopathy with giant negative T waves (apical hypertrophy): ventriculographic and echocardiographic features in 30 patients. Am J Cardiol 1979; 44: 401–12.
40. Maron BJ, Bonow RO, Seshagiri TNR, Roberts WC, Epstein SE. Hypertrophic cardiomyopathy with ventricular septal hypertrophy localized to the apical region of the left ventricle (apical hypertrophic cardiomyopathy). Am J Cardiol 1982; 49: 1838–48.
41. Keren G, Belhassen B, Sherez J, et al. Apical hypertrophic cardiomyopathy: evaluation by noninvasive and invasive techniques in 23 patients. Circulation 1985; 71: 45–56.
42. Maron BJ, Epstein SE. Hypertrophic cardiomyopathy: recent observations regarding the specificity of three hallmarks of the disease: asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol 1980; 45: 141–54.
43. Henry WL, Clark CE, Griffith JM, Epstein SE. Mechanism of left ventricular outflow obstruction in patients with obstructive asymmetric septal hypertrophy (idiopathic hypertrophic subaortic stenosis). Am J Cardiol 1975; 35: 337–45.
44. Spirito P, Maron BJ. Significance of left ventricular outflow tract cross-sectional area in hypertrophic cardiomyopathy: a two-dimensional echo-cardiographic assessment. Circulation 1983; 67: 1100–8.
45. Maron BJ, Edwards JE, Henry WL, Clark CE, Bingle GJ, Epstein SE. Asymmetric septal hypertrophy (ASH) in infancy. Circulation 1974; 50: 809–20.
46. Maron BJ, Tajik AJ, Ruttenberg HD, et al. Hypertrophic cardiomyopathy in infants: clinical features and natural history. Circulation 1982; 65: 7–17.
47. Gutgesell HP, Speer ME, Rosenberg HS. Characterization of the cardiomyopathy in infants of diabetic mothers. Circulation 1980; 61: 441–50.
48. Maron BJ, Spirito P, Wesley Y, Arce J. Development and progression of left ventricular hypertrophy in children with hypertrophic cardiomyopathy. N Engl J Med 1986; 315: 610–4.
49. Spirito P, Maron BJ. Absence of progression of left ventricular hypertrophy in adult patients with hypertrophic cardiomyopathy. J Am Coll Cardiol (in press).
50. Van Noorden S, Olsen EGJ, Pearse AGE. Hypertrophic obstructive cardiomyopathy, a histological, histochemical, and ultrastructural study of biopsy material. Cardiovasc Res 1971; 5: 118–31.
51. Ferrans VJ, Morrow AG, Roberts WC. Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis: a study of operatively excised left ventricular outflow tract muscle in 14 patients. Circulation 1972; 45: 769–92.
52. Maron BJ, Roberts WC. Quantitative analysis of cardiac muscle cell disorganization in the ventricular septum of patients with hypertrophic cardiomyopathy. Circulation 1979; 59: 689–706.
53. Fujiwara H, Kawai C, Hamashima Y. Myocardial fascicle and fiber disarray in 25 μ-thick sections. Circulation 1979; 59: 1293–8.
54. Maron BJ, Anan TJ. Roberts WC. Quantitative analysis of the distribution of cardiac muscle cell disorganization in the left ventricular wall of patients with hypertrophic cardiomyopathy. Circulation 1981; 63: 882–94.
55. St. John Sutton MG, Lie JT, Anderson KR, O'Brien PC, Frye RL. Histopathological specificity of hypertrophic obstructive cardiomyopathy: myocardial fibre disarray and myocardial fibrosis. Br Heart J 1980; 44: 433–43.
56. van der Bel-Kahn J. Muscle fiber disarray in common heart diseases. Am J Cardiol 1977; 40: 355–64.
57. Bulkley BH, Weisfeldt ML, Hutchins GM. Isometric cardiac contraction: a possible cause of the disorganized myocardial pattern of idiopathic hypertrophic subaortic stenosis. N Engl J Med 1977; 296: 135–9.
58. Maron BJ, Wolfson JK. Epstein SE, Roberts WC. Intramural (“small vessel”) coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 1986; 8: 545–57.
59. Tanaka M, Fujiwara H, Onodera T. Wu D-J, Hamashima Y. Kawai C. Quantitative analysis of myocardial fibrosis in normals, hypertensive hearts, and hypertrophic cardiomyopathy. Br Heart J 1986; 55: 575–81.
60. Maron BJ, Epstein SE, Roberts WC. Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries. Am J Cardiol 1979; 43: 1086–102.
61. Pitcher D, Wainwright R. Maisey M, Curry P, Sowton E. Assessment of chest pain in hypertrophic cardiomyopathy using exercise thallium-201 myocardial scintigraphy. Br Heart J 1980; 44: 650–6.
62. Hanrath P, Mathey D, Montz R. et al. Myocardial Thallium201 imaging in hypertrophic obstructive cardiomyopathy. Eur Heart J 1981; 2: 177–85.
63. Nagata S, Park Y-d, Minamikawa T. et al. Thallium perfusion and cardiac enzyme abnormalities in patients with familial hypertrophic cardiomyopathy. Am Heart J 1985; 109: 1317–22.
64. James TN, Marshall TK. De subitaneis mortibus. XII. Asymmetrical hypertrophy of the heart. Circulation 1975; 51: 1149–66.
65. Maron BJ, Nichols PF III, Pickle LW, Wesley YE, Mulvihill JJ. Patterns of inheritance in hypertrophic cardiomyopathy: assessment by M-mode and two-dimensional echocardiography. Am J Cardiol 1984; 53: 1087–94.
66. Maron BJ, Mulvihill JJ. The genetics of hypertrophic cardiomyopathy. Ann Intern Med 1986; 105: 610–3.
67. Clark CE, Henry WL, Epstein SE. Familial prevalence and genetic transmission of idiopathic hypertrophic subaortic stenosis. N Engl J Med 1973; 289: 709–14.
68. ten Cate FJ, Hugenholtz PG. van Dorp WG, Roelandt J. Prevalence of diagnostic abnormalities in patients with genetically transmitted asymmetric septal hypertrophy. Am J Cardiol 1979; 43: 731–7.
69. Chahine RA, Raizner AE, Ishimori T, Montero achéal. Echocardiographic, haemodynamic and angiographic correlations in hypertrophic cardiomyopathy. Br Heart J 1977; 39: 945–53.
70. Borer JS, Bacharach SL, Green MV, et al. Effect of septal myotomy and myectomy on left ventricular systolic function at rest and during exercise in patients with IHSS. Circulation 1979; 60: Suppl 1: I-82–I-87.
71. Pouleur H, Rousseau MF, van Eyll C, Brasseur LA, Charlier AA. Force-velocity-length relations in hypertrophic cardiomyopathy: evidence of normal or depressed myocardial contractility. Am J Cardiol 1983; 52: 813–7.
72. Wigle ED, Marquis Y, Auger P. Muscular subaortic stenosis: initial left ventricular inflow tract pressure in the assessment of intraventricular pressure differences in man. Circulation 1967; 35: 1100–17.
73. Criley JM, Lewis KB, White RI Jr, Ross RS. Pressure gradients without obstruction: a new concept of “hypertrophic subaortic stenosis”. Circulation 1965; 32: 881–7.
74. Ross J Jr, Braunwald E. Gault JH, Mason DT, Morrow AG. The mechanism of the intraventricular pressure gradient in idiopathic hypertrophic subaortic stenosis. Circulation 1966; 34: 558–78.
75. Goodwin JF. The frontiers of cardiomyopathy. Br Heart J 1982; 48: 1–18.
76. Murgo JP, Alter BR, Dorethy JF, Altobelli SA, McGranahan GM Jr. Dynamics of left ventricular ejection in obstructive and nonobstructive hypertrophic cardiomyopathy. J Clin Invest 1980; 66: 1369–82.
77. Hernandez RR, Greenfield JC Jr, McCall BW. Pressure-flow studies in hypertrophic subaortic stenosis. J Clin Invest 1964; 43: 401–7.
78. Siegel RJ, Criley JM. Comparison of ventricular emptying with and without a pressure gradient in patients with hypertrophic cardiomyopathy. Br Heart J 1985; 53: 283–91.
79. Sugrue DD, McKenna WJ, Dickie S, et al. Relation between left ventricular gradient and relative stroke volume ejected in early and late systole in hypertrophic cardiomyopathy: assessment with radionuclide cineangiography. Br Heart J-1984; 52: 602–9.
80. Maron BJ, Gottdiener JS, Arce J, Rosing DR, Wesley YE, Epstein SE. Dynamic subaortic obstruction in hypertrophic cardiomyopathy: analysis by pulsed Doppler echocardiography. J Am Coll Cardiol 1985; 6: 1–8.
81. Pollick C, Morgan CD, Gilbert BW, Rakowski H, Wigle ED. Muscular subaortic stenosis: the temporal relationship between systolic anterior motion of the anterior mitral leaflet and the pressure gradient. Circulation 1982; 66: 1087–94.
82. Pollick C, Rakowski H, Wigle ED. Muscular subaortic stenosis: the quantitative relationship between systolic anterior motion and the pressure gradient. Circulation 1984; 69: 43–9.
83. Gardin JM, Dabestani A, Glasgow GA, Butman S, Burn CS, Henry WL. Echocardiographic and Doppler flow observations in obstructed and nonobstructed hypertrophic cardiomyopathy. Am J Cardiol 1985; 56: 614–21.
84. Jenni R, Ruffmann K. Vieli A, Anliker M, Krayenbuchl HP. Dynamics of aortic flow in hypertrophic cardiomyopathy. Eur Heart J 1985; 6: 391–8.
85. Yock PG, Hatle L, Popp RL. Patterns and timing of Doppler-detected intracavitary and aortic flow in hypertrophic cardiomyopathy. J Am Coll Cardiol 1986; 8: 1047–58.
86. Maron BJ, Epstein SE. Clinical significance and therapeutic implications of the left ventricular outflow tract pressure gradient in hypertrophic cardiomyopathy. Am J Cardiol 1986; 58: 1093–6.
87. Wigle ED. Hypertrophic cardiomyopathy: a 1987 viewpoint. Circulation 1987; 75: 311–22.
88. Pierce GE, Morrow AG, Braunwald E. Idiopathic hypertrophic subaortic stenosis: III. Intraoperative studies of the mechanism of obstruction and its hemodynamic consequences. Circulation 1964; 30: Suppl 4: IV-152–IV-213.
89. Grose R, Strain J, Spindola-Franco H. Angiographic and hemodynamic correlations in hypertrophic cardiomyopathy with intracavitary systolic pressure gradients. Am J Cardiol 1986; 58: 1085–92.
90. Shah PM, Gramiak R, Kramer DH. Ultrasound location of left ventricular outflow obstruction in hypertrophic obstructive cardiomyopathy. Circulation 1969; 40: 3–11.
91. Henry WL, Clark CE, Glancy DL, Epstein SE. Echocardiographic measurement of the left ventricular outflow gradient in idiopathic hypertrophic subaortic stenosis. N Engl J Med 1973; 288: 989–93.
92. Popp RL, Harrison DC. Ultrasound in the diagnosis and evaluation of therapy of idiopathic hypertrophic subaortic stenosis. Circulation 1969; 40: 905–14.
93. Spirito P, Maron B J. Patterns of systolic anterior motion of the mitral valve in hypertrophic cardiomyopathy: assessment by two-dimensional echocardiography. Am J Cardiol 1984; 54: 1039–46.
94. Boughner DR, Schuld RL, Persaud JA. Hypertrophic obstructive cardiomyopathy: assessment by echocardiographic and Doppler ultrasound techniques. Br Heart J 1975; 37: 917–23.
95. Wigle ED, Auger P, Marquis Y. Muscular subaortic stenosis: the direct relation between the intraventricular pressure difference and the left ventricular ejection time. Circulation 1967; 36: 36–44.
96. Ibrahim M, Silie M, Delahaye J-P, Froment R. Systolic time intervals in valvular aortic stenosis and idiopathic hypertrophic subaortic stenosis. Br Heart J 1973; 35: 276–83.
97. Morrow AG, Reitz BA, Epstein SE, et al. Operative treatment in hypertrophic subaortic stenosis: techniques, and the results of pre and postoperative assessments in 83 patients. Circulation 1975; 52: 88–102.
98. Bigelow WG, Trimble AS, Wigle ED, et al. The treatment of muscular subaortic stenosis. J Thorac Cardiovasc Surg 1974; 68: 384–92.
99. Agnew TM, Barratt-Boyes BG, Brandt PWT, Roche AHG, Lowe JB, O'Brien KP. Surgical resection in idiopathic hypertrophic subaortic stenosis with a combined approach through aorta and left ventricle. J Thorac Cardiovasc Surg 1977; 74: 307–16.
100. Reis RL, Hannah H III, Carley JE, Pugh DM. Surgical treatment of idiopathic hypertrophic subaortic stenosis (IHSS): postoperative results in 30 patients following ventricular septal myotomy and myectomy (Morrow procedure). Circulation 1977; 56: Suppl 2: II-128–II-132.
101. Maron BJ. Merrill WH, Freier PA, Kent KM, Epstein SE, Morrow AG. Long-term clinical course and symptomatic status of patients after operation for hypertrophic subaortic stenosis. Circulation 1978; 57: 1205–13.
102. Maron BJ. Epstein SE, Morrow AG. Symptomatic status and prognosis of patients after operation for hypertrophic obstructive cardiomyopathy: efficacy of ventricular septal myotomy and myectomy. Eur Heart J 1983; 4: Suppl F: 175–85.
103. Beahrs MM, Tajik AJ, Seward JB, Giuliani ER, McGoon DC. Hypertrophic obstructive cardiomyopathy: ten- to 21-year follow-up after partial septal myectomy. Am J Cardiol 1983; 51: 1160–6.
104. Spirito P. Maron BJ. Rosing DR. Morphologic determinants of hemodynamic state after ventricular septal myotomy-myectomy in patients with obstructive hypertrophic cardiomyopathy: M mode and two-dimensional echocardiographic assessment. Circulation 1984; 70: 984–95.
105. Schapira JN. Stemple DR. Martin RP, Rakowski H, Stinson EB, Popp RL. Single and two-dimensional echocardiographic visualization of the effects of septal myectomy in idiopathic hypertrophic subaortic stenosis. Circulation 1978; 58: 850–60.
106. Bolton MR Jr, King JF, Polumbo RA, et al. The effects of operation on the echocardiographic features of idiopathic hypertrophic subaortic stenosis. Circulation 1974; 50: 897–900.
107. Fighali S, Krajcer Z, Leachman RD. Septal myomectomy and mitral valve replacement for idiopathic hypertrophic subaortic stenosis: short- and long-term follow-up. J Am Coll Cardiol 1984; 3: 1127–34.
108. Bircks W, Schulte HD. Surgical treatment of hypertrophic obstructive cardiomyopathy with special reference to complications and to atypical hypertrophic obstructive cardiomyopathy. Eur Heart J 1983; 4: Suppl F: 187–90.
109. Turina J, Jenni R, Krayenbuehl HP, Turina M, Rothlin M. Echocardiographic findings late after myectomy in hypertrophic obstructive cardiomyopathy. Eur Heart J 1986; 7: 685–92.
110. Wigle ED, Trimble AS, Adelman G. Bigelow WG. Surgery in muscular subaortic stenosis. Prog Cardiovasc Dis 1968; 11: 83–112.
111. Kinoshita N, Nimura Y, Okamoto M. Miyatake K, Nagata S, Sakakibara H. Mitral regurgitation in hypertrophic cardiomyopathy: non-invasive study by two dimensional Doppler echocardiography. Br Heart J 1983; 49: 574–83.
112. Wigle ED, Adelman AG, Auger P, Marquis Y. Mitral regurgitation in muscular subaortic stenosis. Am J Cardiol 1969; 24: 698–706.
113. Stewart S, Mason DT, Braunwald E. Impaired rate of left ventricular filling in idiopathic hypertrophic subaortic stenosis and valvular aortic stenosis. Circulation 1968; 37: 8–14.
114. Moreyra E, Klein JJ, Shimada H, Segal BL. Idiopathic hypertrophic subaortic stenosis diagnosed by reflected ultrasound. Am J Cardiol 1969; 23: 32–7.
115. Gaasch WH, Levine HJ, Quinones MA, Alexander JK. Left ventricular compliance: mechanisms and clinical implications. Am J Cardiol 1976; 38: 645–53.
116. Sanderson JE, Gibson DG, Brown DJ, Goodwin JF. Left ventricular filling in hypertrophic cardiomyopathy: an angiographic study. Br Heart J 1977; 39: 661–70.
117. St. John Sutton MG, Tajik AJ, Gibson DG, Brown DJ, Seward JB, Giuliani ER. Echocardiographic assessment of left ventricular filling and septal and posterior wall dynamics in idiopathic hypertrophic subaortic stenosis. Circulation 1978; 57: 512–20.
118. Hanrath P. Mathey DG, Siegert R, Bleifeld W. Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: an echocardiographic study. Am J Cardiol 1980; 45: 15–23.
119. Bonow RO, Rosing DR, Bacharach SL, et al. Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation 1981; 64: 787–96.
120. Spirito P, Maron BJ, Chiarella F, et al. Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy. Circulation 1985; 72: 310–6.
121. Grossman W, McLaurin LP. Diastolic properties of the left ventricle. Ann Intern Med 1976; 84: 316–26.
122. Alvares RF, Shaver JA. Gamble WH, Goodwin JF. Isovolumic relaxation period in hypertrophic cardiomyopathy. J Am Coll Cardiol 1984; 3: 71–81.
123. Betocchi S, Bonow RO, Bacharach SL, Rosing DR, Maron BJ, Green MV. Isovolumic relaxation period in hypertrophic cardiomyopathy: assessment by radionuclide angiography. J Am Coll Cardiol 1986; 7: 74–81.
124. Nayler WC, Williams A. Relaxation in heart muscle: some morphological and biochemical considerations. Eur J Cardiol 1978; 7: Suppl: 35–50.
125. Mann T, Goldberg S, Mudge GH Jr, Grossman W. Factors contributing to altered left ventricular diastolic properties during angina pectoris. Circulation 1979; 59: 14–20.
126. Brutsaert DL, Rademakers FE, Sys SU. Triple control of relaxation: implications in cardiac disease. Circulation 1984; 69: 190–6.
127. Hess OM, Grimm J, Krayenbuehl HP. Diastolic function in hypertrophic cardiomyopathy: effects of propanolol and verapamil on diastolic stiffness. Eur Heart J 1983; 4: Suppl F: 47–56.
128. Hanrath P, Mathey DG, Kremer P, Sonntag F, Bleifeld W. Effect of verapamil on left ventricular isovolumic relaxation time and regional left ventricular filling in hypertrophic cardiomyopathy. Am J Cardiol 1980; 45: 1258–64.
129. Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF. Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy. Circulation 1982; 65: 499–507.
130. Paulus WJ, Lorell BH, Craig WE, Wynne J, Murgo JP, Grossman W. Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy: altered left ventricular loading or improved muscle inactivation? J Am Coll Cardiol 1983; 2: 879–86.
131. Anderson DM, Raff GL, Ports TA, Brundage BH, Parmley WW, Chatterjee K. Hypertrophic obstructive cardiomyopathy: effects of acute and chronic verapamil treatment on left ventricular systolic and diastolic function. Br Heart J 1984; 51: 523–9.
132. Bonow RO, Dilsizian V, Rosing DR. Maron BJ, Bacharach SL, Green MV. Verapamil-induced improvement in left ventricular diastolic filling and increased exercise tolerance in patients with hypertrophic cardiomyopathy: short- and long-term effects. Circulation 1985; 72: 853–64.
133. Hess OM, Murakami T, Krayenbuehl HP. Does verapamil improve left ventricular relaxation in patients with myocardial hypertrophy? Circulation 1986; 74: 530–43.
134. TenCate FJ, Serruys PW, Mey S, Roelandt J. Effects of short-term administration of verapamil on left ventricular relaxation and filling dynamics measured by a combined hemodynamic-ultrasonic technique in patients with hypertrophic cardiomyopathy. Circulation 1983; 68: 1274–9.
135. Wilmshurst PT, Thompson DS, Juul SM, et al. Effects of verapamil on haemodynamic function and myocardial metabolism in patients with hypertrophic cardiomyopathy. Br Heart J 1986; 56: 544–53.
136. Lorell BH, Barry WH. Effects of verapamil on contraction and relaxation of cultured chick embryo ventricular cells during calcium overload. J Am Coll Cardiol 1984; 3: 341–8.
137. Thompson DS, Naqvi N, Juul SM, et al. Effects of propranolol on myocardial oxygen consumption, substrate extraction, and haemodynamics in hypertrophic obstructive cardiomyopathy. Br Heart J 1980; 44: 488–98.
138. Pasternac A, Noble J, Streulens Y, Elie R, Henschke C, Bourassa MG. Pathophysiology of chest pain in patients with cardiomyopathies and normal coronary arteries. Circulation 1982; 65: 778–89.
139. Cannon RO III, Rosing DR, Maron BJ, et al. Myocardial ischemia in patients with hypertrophic cardiomyopathy: contribution of inadequate vasodilator reserve and elevated left ventricular filling pressures. Circulation 1985; 71: 234–43.
140. Rubin KA, Morrison J, Padnick MB. et al. Idiopathic hypertrophic subaortic stenosis: evaluation of anginal symptoms with thallium-201 myocardial imaging. Am J Cardiol 1979; 44: 1040–5.
141. St. John Sutton MG, Tajik AJ, Smith HC, Ritman EL. Angina in idiopathic hypertrophic subaortic stenosis: a clinical correlate of regional left ventricular dysfunction: a videometric and echocardiographic study. Circulation 1980; 61: 561–8.
142. Weiss MB, Ellis K, Sciacca RR, Johnson LL, Schmidt DH, Cannon PJ. Myocardial blood flow in congestive and hypertrophic cardiomyopathy: relationship to peak wall stress and mean velocity of circumferential fiber shortening. Circulation 1976; 54: 484–94.
143. Lund DD, Tomanek RJ. Myocardial morphology in spontaneously hypertensive and aortic-constricted rats. Am J Anat 1978; 152: 141–51.
144. Pichard AD, Meller J, Teichholz LE, Lipnik S, Gorlin R, Herman MV. Septal perforator compression (narrowing) in idiopathic hypertrophic subaortic stenosis. Am J Cardiol 1977; 40: 310–4.
145. Marcus ML, Doty DB, Hiratzka LF, Wright CB, Eastham CL. Decreased coronary reserve: a mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. N Engl J Med 1982; 307: 1362–6.
146. Bailey IK, Come PC, Kelly DT, et al. Thallium-201 myocardial perfusion imaging in aortic valve stenosis. Am J Cardiol 1977; 40: 889–99.
147. Opherk D, Mall G, Zebe H, et al. Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. Circulation 1984; 69: 1–7.