The physiology of excitatory amino acids in the vertebrate central nervous system

Progress in Neurobiology

Volumn 28, Issue 3, 1987, Pages 197-276

  Mayer, Mark L ^a   Westbrook, Gary L ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; AMINOSUBERIC ACID; GAMMA GLUTAMYLAMINOMETHYLSULFONIC ACID; GAMMA GLUTAMYLGLYCINE; GLUTAMIC ACID; HOMOCYSTEIC ACID; KAINIC ACID; N METHYLASPARTIC ACID; QUISQUALIC ACID; UNCLASSIFIED DRUG;

ANIMAL; CENTRAL NERVOUS SYSTEM; DRUG EFFICACY; NERVOUS SYSTEM; NONHUMAN; REVIEW; VERTEBRATE;

AMINO ACIDS; ANIMAL; ASPARTIC ACID; CENTRAL NERVOUS SYSTEM; GLUTAMATES; GLUTAMIC ACID; KAINIC ACID; MEMBRANE POTENTIALS; N-METHYLASPARTATE; NEUROTRANSMITTERS; OXADIAZOLES; QUISQUALIC ACID; RECEPTORS, AMINO ACID; RECEPTORS, CELL SURFACE; SUPPORT, NON-U.S. GOV'T; VERTEBRATES;

EID: 0023125256     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/0301-0082(87)90011-6     Document Type: Review

References (429)

1. The permeability of endplate channels to monovalent and divalent cations
2. Drug blockade of open end-plate channels
3. l-glutamate as possible neurotransmitter in the ampullae of Lorenzi of the skate
4. A reinterpretation of mammalian sodium channel gating based on single channel recording
5. A non-selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions
6. Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single file pore
7. Effects of glutamate, aspartate, and two presumed antagonists on feline rubrospinal neurones
8. Glutamate current noise: post-synaptic channel kinetics investigated under voltage-clamp
9. Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction
10. The excitation of thalamic neurones by acetylcholine
11. Possible mechanism for long-lasting potentiation of synaptic transmission in hippocampal slices from guinea pigs
12. Specific long-lasting potentiation of synaptic transmission in hippocampal slices
13. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
14. Cyclazocine, like ketamine, blocks N-ethyl-aspartate actions on spinal neurones in cat and rat
15. Ketamine anaesthesia via N-methyl-aspartate and acetylcholine receptor blockade?
16. Influence of agonists on desensitisation of glutamate receptors on locust muscle
17. Lack of involvement of N-methyl aspartate receptors in segmental synaptic excitation of cat lumbar dorsal horn neurones: studies with ketamine
18. Pharmacology of the vestibular hair cell-afferent fiber synapse in the frog
19. Permeability of the post-synaptic membrane of an excitatory glutamate synapse to sodium and potassium
20. Threshold effects of N-methyl-d-aspartic acid and 2-amino 5-phosphonovaleric acid (2APV) on the spontaneous activity of neocortical single neurones in the urethane anaesthetised rat
21. Calcium permeability of the channels activated by N-methyl-d-aspartate (NMDA) in mouse central neurons
22. a patch-clamp study of excitatory amino acid activated channels
23. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations
24. The structural specificity of the high affinity uptake of l-glutmate and l-aspartate by rat brain slices
25. CNS depressants: effects on post-synaptic pharmacology
26. Noradrenaline and acetylcholine responses of supraoptic neurosecretory cells
27. Phenobarbitone modulation of post-synaptic GABA receptor function on cultured mammalian neurones
28. Convulsant-induced depression of amino acid responses in cultured mouse spinal neurons studied under voltage clamp
29. Amino acid pharmacology of mammalian central neurones grown in tissue culture
30. Hypothesis regarding the cellular mechanisms responsible for long-term potentiation in the hippocampus
31. Kainate, N-methyl-d-aspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro
32. Effects of d,l,-a-aminoadipate on postsynaptic amino acid responses in cultured mouse spinal cord neurons
33. Intracellular studies on the action of l-glutamate on spinal neurones of the cat
34. Comparison of σ- and κ-opiate receptor ligands as excitatory amino acid antagonists
35. The effects of cyclic dicarboxylic acids on spontaneous and amino acid-evoked activity of rat cortical neurones
36. Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by d-α-aminoadipate, α,ε-diaminopimelic acid and HA-966
37. d-α-aminoadipate, α,ε-diaminopimelic acid and HA-966 as antagonists of amino acid-induced and synaptic excitation of mammalian spinal neurones in vivo
38. d-α-aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones
39. The sensitivity of rat spinal interneurones and Renshaw cells to l-glutamate and l-aspartate
40. Effects of d-α-aminoadipate on excitation of afferent fibres in the lateral line of Xenopus laevis
41. Long-lasting potentiation of synaptic transmission in the dentate area of the unaesthetised rabbit following stimulation of the perforant path
42. Reduction of long-term potentiation in the dentate gyrus of the rat following selective depletion of monoamines
43. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetised rabbit following stimulation of the perforant path
44. Anaesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microiontophoresis
45. Glutamate and aspartate mimic the afferent transmitter in the cochlea
46. 1-Hydroxy-3-amino-pyrrolidone-2 (HA-966): a new GABA-like compound, with potential use in extrapyramidal disease
47. Depolarizing actions of γ-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro
48. The role of putative amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. I. The effects of excitatory amino acid antagonists
49. N-methyl-d-aspartate (NMDA), kainate and quisqualate receptors and the generation of fictive locomotion in the lamprey spinal cord
50. Actions of GABA on mammalian neurones, axons, and nerve terminals
51. Inhibition of GABA uptake potentiates the conductance increase produced by GABA-mimetic compounds on single neurones in isolated olfactory cortex slices of the guinea pig
52. Voltage clamp analysis of mossy fiber synaptic input to hippocampal neurons
53. The ionic mechanism of the excitatory action of l-glutamate upon the membranes of motoneurones of the frog
54. Glutamate neurotoxicity in cortical cell culture is calcium dependent
55. Sensitivity of Purkinje cell dendrites to glutamic acid
56. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells
57. Pharmacological studies on a locust neuromuscular preparation
58. Ketamine and N-allynormetazocine selectively inhibit an N-methyl-d-aspartate-receptor-mediated component of synaptic transmission in rat hippocampal slices
59. Magnesium ions block an N-methyl-d-aspartate receptormediated component of synaptic transmission in rat hippocampus
60. Pharmacological antagonism of climbing fibre-, parallel fibre-, and acidic amino acid-induced excitation of frog cerebellar Purkinje cells
61. The neuronal correlate of locomotion in fish
62. An evaluation of d-α-aminoadipate and d- (and dl) α-aminosuberate as selective antagonists of excitatory amino acids in the substantia nigra and mesencephalic reticular formation of the rat
63. The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro
64. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
65. Some effects of excitatory amino acid receptor antagonists on synaptic transmission in the rat olfactory cortex slice
66. Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels
67. Intracellularly-recorded effects of glutamate and aspartate on neurones in the guinea-pig olfactory cortex slice
68. Amino acid-evoked depolarization of electrically inexcitable (neuroglial?) cells in the guinea pig olfactory cortex slice
69. Science and technology of patch-recording electrodes
70. An overview of glutamate as a neurotransmitter
71. On the elementary conductance event produced by l-glutamate and quanta of the natural transmitter at the neuromuscular junctions of maia squinado
72. Effect of glutamate, aspartate and related derivatives on cerebellar Purkinje cell dendrites in the rat: an in vitro study
73. Connectivity and chemosensitivity of Purkinje cells in the immature rat cerebellum: an in vitro study
74. Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro
75. Antagonist activity of methyl-substituted analogues of 2-amino-4-phosphonobutanoic acid in the hippocampal slice
76. Anticonvulsant action of excitatory amino acid antagonists
77. Intracellularly recorded synaptic antagonism in the rat dentate gyrus
78. The reversal potential of excitatory amino acid action on granule cells of the rat dentate gyrus
79. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus
80. 2+ dependence of membrane resistance increases evoked by NMDA in hippocampal neurones
81. Two types of extrajuctional l-glutamate receptors in locust muscle fibres
82. Glutamate sensitivity and distribution of receptors along normal and denervated locust muscle fibres
83. 2-amino-4-phosphonobutyric acid as a glutamate antagonist on locust muscle
84. Properties of miniature excitatory junctional currents at the locust nerve-muscle junction
85. Single glutamate-activated channels recorded from locust muscle fibres with perfused patch-clamp electrodes
86. Ion channels activated by l-glutamate and GABA in cultured cerebellar neurons of the rat
87. Rapid kinetics of single glutamate-receptor channels
88. Effects of injectable anaesthetics on responses to l-glutamate and on spontaneous synaptic activity in lamprey reticulo-spinal neurones
89. Excitation of mammalian central neurones by acidic amino acids
90. Amino acid transmitters in the mammalian central nervous system
91. Antagonism of neuronal excitation by 1-hydroxy-3-aminopyrrolidone-2
92. The excitation and depression of spinal neurones by ibotenic acid
93. Chemical excitation of spinal neurones
94. The excitation of spinal neurones by certain acidic amino acids
95. Acidic amino acids with strong excitatory actions on mammalian neurones
96. Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming
97. Dual-component amino acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos
98. Effects of d-α-aminoadipate on physiologically evoked responses of cat dorsal horn neurones
99. Conformational aspects of the actions of some piperidine dicarboxylic acids at excitatory amino acid receptors in the mammalian and amphibian spinal cord
100. Antagonism of excitatory amino-acid induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate
101. Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system
102. Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous system
103. Dipeptide antagonists of amino acid-induced and synaptic excitation in the vertebrate central nervous system
104. 2-amino-5-phosphonovalerate (2-APV), a potent and selective antagonist of amino acid-induced and synaptic excitation
105. Microelectrophoretic studies on the depressant action of HA-966 on chemically and synaptically excited neurones in the cat cerebral cortex and cuneate nucleus
106. Antagonism of synaptic and amino acid induced excitation in the cuneate nucleus of the cat by HA-966
107. Effects of magnesium ions on the responses of spinal neurones to excitatory amino acids and acetylcholine
108. Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord
109. Differentiation of kainate and quisqualate receptors in cat spinal cord by selective antagonism with γ-d (and l)-glutamylglycine
110. Selective excitatory amino acid antagonist action of γ-d-glutamylaminomethyl-sulphonate (GAMS) on cat spinal neurones
111. Actions of d and l forms of 2-aminophosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord
112. role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord
113. Depressant actions of γ-d-glutamylaminomethyl sulfonate (GAMS) on amino acid-induced and synaptic excitation in the cat spinal cord
114. Pharmacological properties of feline red nucleus
115. GABA-depolarization of a sensory ganglion: antagonism by picrotoxin and bicuculline
116. Depolarization of dorsal root ganglia in the cat by GABA and related amino acids: antagonism by picrotoxin and bicuculline
117. Permeability changes induced by l-glutamate at the crayfish neuromuscular junction
118. The nature of the neuromuscular block produced by magnesium
119. Kinetics and mechanism of reactions of main group metal ions with biological carriers
120. N-methylaspartate activates voltage-dependent calcium conductances in rat hippocampal pyramidal cells
121. Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox
122. The excitatory action of acetylcholine on hippocampal neurones of the guinea pig and rat maintained in vitro
123. The excitatory amino acid antagonist γ-d-glutamylglycine masks rather than prevents long term potentiation of the perforant path
124. Long-term potentiation of the perforant path in vivo is associated with increased glutamate release
125. Inhibitory modulation of long-term potentiation: evidence for a postsynaptic locus of control
126. Investigations into the mechanism of excitant amino acid cytotoxicity using a well-characterized glutamatergic system
127. An intracellular study of the action of N-methyl-dl-aspartate with ketamine in the mouse hippocampal slice
128. In vitro excitation of hippocampal pyramidal cell dendrites by glutamic acid
129. Nonlinear voltage dependence of excitatory synaptic current in crayfish muscle
130. The differential sensitivity to l-glutamate and l-aspartate of spinal interneurones and Renshaw cells
131. Long-term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequecy dependency
132. The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation
133. Synaptic transmission is required for initiation of long-term potentiation
134. Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice
135. Calcium in long-term potentiation as a model for memory
136. The selectivity of ion channels in nerve and muscle
137. Effects of kynurenate on root potentials evoked by synaptic activity and amino acids in the frog spinal cord
138. The action of N-methyl-d-aspartate and kainic acids on motoneurones with emphasis on conductance changes
139. The actions of excitatory amino acids on motoneurones in the feline spinal cord
140. The effect of lectins on desensitisation of locust muscle glutamate receptors
141. Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog
142. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations
143. 2+ of amino acid-induced depolarizations of spinal neurones
144. 2+-like selective antagonism of excitatory amino acid-induced responses by α,ε-diaminopimelic acid, d-α-aminoadipate and HA-966 in isolated spinal cord frog and immature rat
145. Differential role of excitant amino acid receptors in spinal transmission
146. Dual sites for antagonism of excitatory amino acid actions on central neurones
147. Specific antagonism of excitant amino acids in the isolated spinal cord of the neonatal rat
148. Evidence that receptors mediating central synaptic potentials extend beyond the postsynaptic density
149. Structure-activity relationships of l-glutamate receptor ligands: role of the ω-acidic terminal
150. 2+-dependent l-glutamate binding sites do not correspond to 2-amino-4-phosphonobutanoate-sensitive excitatory amino acid receptors
151. Discrimination of excitatory amino acid receptor sub-types using radioligand binding techniques
152. Selective association of N-methyl aspartate and quisqualate types of l-glutamate receptor with brain postsynaptic densities
153. Classification and properties of acidic amino acid receptors in hippocampus. I. Electrophysiological studies of an apparent desensitisation and interactions with drugs which block transmission
154. Desensitisation to glutamate does not affect synaptic transmission in rat hippocampal slices
155. 14C] glutamate from hippocampal slices: an ex vivo study in the rat
156. Desensitisation at the frog neuromuscular junction: a biphasic process
157. γ-Aminobutyric acid and a caudato-nigral inhibition
158. Free and conjugated amino acids in human CSF: influence of age and sex
159. N-acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract
160. Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor
161. Glutamate-operated postsynaptic channels and spontaneous excitatory postsynaptic currents in crayfish claw opener muscle
162. The synaptic current evoked in cat spinal motoneurones by impulses in single group 1a axons
163. The variation in action of excitatory amino acids in relation to distance of iontophoretic application to spinal motoneurones
164. Multiple actions of N-methyl-d-aspartate on cat neocortical neurons in vitro
165. Glutamate: a neurotransmitter in mammalian brain
166. Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors
167. Synaptic localisation of kainic acid binding sites
168. Dipeptide antagonists of amino acid-induced and synaptic excitation in the frog spinal cord
169. Single synaptic channels recorded at glutamate sensitive patches on a crayfish muscle
170. Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axon
171. Antagonist activity of phosphorus-containing glutamate analogues in the perforant path
172. Effects of anaesthetics on ions channels in synapses
173. Acidic amino acid antagonists of lateral perforant path synaptic transmission: agonist-antagonist interactions in the dentate gyrus
174. Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord
175. Cellular uptake disguises action of l-glutamate on N-methyl-d-aspartate receptors
176. Mono- and multisynaptic origin of the early surface-negative wave recorded from guinea-pig olfactory cortex in vitro
177. Intracellular calcium and the control of neuronal pacemaker activity
178. Blockade by glutamic acid diethyl ester of excitation of nucleus tractus solitarii neurons and vasodepressor reponses reflexly elicted by vagal stimulation
179. Autoradiographic characterization of N-methyl-d-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites
180. Activation of NMDA-receptors elicits “fictive locomotion” in lamprey spinal cord in vitro
181. Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes
182. Conductance changes induced by dl-homocysteic acid and N-methyl-dl-aspartic acid in hippocampal neurons
183. N-methyl-d-aspartate receptor antagonists reduce synaptic excitation in the hippocampus
184. Excitation of hippocampal pyramidal cells by glutamate in the guinea-pig and rat
185. Excitatory amino acids and potassium release in the frog spinal cord
186. The antagonism of the glutamate-induced and synaptic excitations of thalamic neurones
187. The antagonist action of glutamic acid diethyl ester towards amino acid-induced and synaptic excitations of central neurones
188. The actions of certain amino acids as neuronal excitants
189. Improved patch-clamp technique for high-resolution current recording from cells and cell-free membrane patches
190. Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path
191. Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists
192. Long-term potentiation in the hippocampus involves activation of N-methyl-d-aspartate receptors
193. Quantitative studies on some antagonists of N-methyl-d-aspartate in slices of rat cerebral cortex
194. Effects of sodium glutamate on the nervous system
195. Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: evidence for its mediation by quisqualate- or kainate-receptors
196. Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones
197. Intracellular demonstration of an N-methyl-d-aspartate receptor mediated component of synaptic transmission in the hippocampus
198. 2+ in guinea-pig ventricular cells
199. Mechanism of ion permeation through calcium channels
200. Synaptic transmission in suprasylvian visual cortex is reduced by excitatory amino acid antagonists
201. Selective synaptic antagonism by atropine and α-aminoadipate of pulvinar and cortical afferents to the suprasylvian visual area (Clare-Bishop area)
202. Ranking of excitatory amino acids by the antagonists glutamic acid diethyl ester and d-α-aminoadipic acid
203. Amino acids and the synaptic pharmacology of granule cells in the dentate gyrus of the rat
204. An ionophoretic study of the responses of rat caudal trigeminal nucleus neurones to non-noxious mechanical sensory stimuli
205. Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid
206. Frequency-dependent noradrenergic modulation of long-term potentiation in the hippocampus
207. Pharmacological sensitivity of amino acid responses and synaptic activation of in vitro prepyriform neurons
208. Ionic mechanisms underlying the depolarization of l-glutamate on rat and human spinal neurones in tissue culture
209. Efflux of potassium from neurones excited by glutamate and aspartate causes a depolarization of cultured glial cells
210. Expression of functional GABA, glycine and glutamate receptors in Xenopus oocytes injected with rat brain mRNA
211. The response of Renshaw cells and spinal interneurones of the rat to l-glutamate and l-aspartate
212. Quisqualate and l-glutamate inhibit retinal horizontal-cell responses to kainate
213. Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells
214. Non-N-methyl-d-aspartate receptors mediating synaptic transmission in the avian cochlear nucleus: effects of kynurenic acid, dipicolinic acid and streptomycin
215. Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study
216. Ionic basis for the electroresponsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro
217. Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory synaptic potentials and glutamate excitation by kynurenate
218. 1a afferent excitation of motoneurones in the in vitro new-born rat spinal cord is selectively antagonised by kynurenate
219. Structure-activity studies on an excitatory receptor for glutamate on leech Retzius neurones
220. Properties of the larval neuromuscular junction in Drosophila Melanogaster
221. l-glutamate as an excitatory transmitter at the Drosophila neuromuscular junction
222. The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous system
223. Interpretation of voltage-clamp measurements in hippocampal neurons
224. Central nervous system receptors for glutamic acid
225. Spinal interneurone excitation by conformationally restricted analogues of l-glutamic acid
226. Structure-activity relations of dipeptide antagonists of excitatory amino acids
227. A study of the “desensitisation” produced by acetylcholine at the motor end-plate
228. Transformation by concanavalin A of the response of molluscan neurones to l-glutamate
229. The nature of the excitatory transmitter mediating X and Y cell inputs to the cat dorsal geniculate nucleus
230. Aspartate, glutamate and γ-aminobutyric acid depolarize cultured astrocytes
231. Climbing and parallel fiber responses recorded intracellularly from Purkinje cell dendrites in guinea pig cerebellar slices
232. Excitatory amino acid receptors in hippocampal neurons: kainate fails to desensitise them
233. Depolarization of cultured oligodendrocytes by glutamate and GABA
234. Response of Shaffer collateral-CA1 pyramidal cell synapses of the hippocampus to analogues of acidic amino acids
235. Micromolar l-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex
236. Microiontophoretic studies on cortical neurones
237. Iontophoretic studies of neurones in the mammalian cerebral cortex
238. Some properties of unresponsive cells in the cerebral cortex
239. Glutamic acid agonists
240. New class of glutamate agonist structurally related to ibotenic acid
241. Blockade of long-term potentiation in the dentate gyrus of freely moving rats by the glutamic acid antagonist GDEE
242. Characteristics: of fast excitatory postsynaptic current in frog sympathetic ganglion cells
243. The distribution of acetylcholine sensitivity at the post-synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range
244. The interaction between barbiturate anaesthetics and excitatory amino acid responses on cat spinal neurones
245. 2+
246. 2-amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus
247. Recurrent excitation in the CA3 region of rat hippocampus
248. Dynamic model of neuronal response in the rat hippocampus
249. An in vitro preparation for the study of the pharmacology and electrophysiology of the vestibular nuclei
250. Blockade of cholinergic channels by chlorisondamine on a crustacean muscle
251. Comparison of excitatory currents activated by different transmitters on crustacean muscle. II. Glutamate-activated currents and comparison with acetylcholine currents present on the same muscle
252. Selective antagonism by d-α-aminoadipate of amino acid and synaptic excitation of cat spinal neurons
253. 2+ and ketamine-sensitive e.p.s.p. in slices of rat somatosensory cortex: a role for N-methylaspartate receptors
254. Noradrenergic innervation of the adult rat hippocampal formation
255. The biochemistry of memory: a new and specific hypothesis
256. Heterosynaptic depression: a postsynaptic correlate of long-term potentiation
257. Intracellular injections of EGTA block induction of hippocampal long-term potentiation
258. Long term potentiation is accompanied by a reduction in dendritic responsiveness to glutamic acid
259. Voltage clamp study of fast excitatory synaptic currents in bullfrog sympathetic cells
260. Substitution of extracellular sodium ions blocks the voltage-dependent decrease of input conductance evoked by l-aspartate
261. Two distinct inhibitory responses of cultured, mammalian spinal neurones to ibotenic acid
262. A comparison of the action of glutamate, ibotenate and other related amino acids on feline spinal interneurones
263. Neuronal depressant effects of diethylester derivatives of excitatory amino acids
264. dl-Quisqualic and l-aspartic acids activate separate excitatory conductances in cultured spinal cord neurons
265. l-Aspartic acid induces a region of negative slope conductance in the current voltage relationhip of cultured spinal cord neurons
266. l-Aspartic acid potentiates ‘slow’ inward current in cultured spinal cord neurones
267. Two conductance mechanisms activated by applications of l-glutamic, l-aspartic, dl-homocysteic, N-methyl-d-aspartic, and dl-kainic acids to cultured mammalian central neurones
268. The effects of l-glutamate and its analogues upon the membrane conductance of central murine neurones in culture
269. Voltage-dependent calcium channels in glial cells
270. Dependence of acetylcholine desensitisation on the membrane potential of frog muscle fibre and on the ionic changes in the medium
271. The effect of voltage on the time course of end plate currents
272. A quantitative description of end plate currents
273. Effects of iontophoretically applied drugs on spinal interneurones of the lamprey
274. The effects of dl-α-aminoadipate on synaptically and chemically evoked excitation of anteroventral cochlear nucleus neurons of the cat
275. The influence of concanavalin A on glutamate-induced current fluctuations in locust muscle fibres
276. Concanavalin A blocks desensitisation of glutamate receptors on insect muscle fibres
277. Glutamate and synaptic excitation of reticulospinal neurones of lamprey
278. A calcium-activated chloride current generates the after-depolarization of rat sensory neurones in culture
279. Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp
280. The action of N-methyl-d-aspartic acid on mouse spinal neurones in culture
281. Divalent cation permeability of N-methyl-d-aspartate channels
282. 2+ of NMDA responses in spinal cord neurones
283. The piperidine analogues prevent desensitisation of l-glutamate receptors on crustacean muscle
284. The differential sensitivity of spinal interneurones and renshaw cells to kainate and N-methyl-d-aspartate
285. Receptors for excitatory amino acids in the mammalian central nervous system
286. The action of d-α-aminoadipate on excitatory amino acid receptors of rat thalamic neurones
287. On the configuration of the receptors for excitatory amino acids
288. The postexcitatory effects of acidic amino acids on spinal neurones
289. The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord
290. The antagonism of amino acid-induced excitation of spinal neurones in the cat
291. The kindling model of epilepsy: a review
292. Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat
293. Synaptic enhancement in fascia dentata: cooperativity among coactive afferents
294. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters
295. Intracellular calcium and desensitisation of acetylcholine receptors
296. Properties of postsynaptic channels induced by acetylcholine in different frog muscle fibres
297. Synaptic organization and ionic basis of On and Off channels in Mudpuppy retina
298. Heterosynaptic postactivation potentiation in hippocampal CA3 neurons: long-term changes in postsynaptic potentials
299. Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis
300. 3H]Glutamate-binding sites in rat brain
301. Anatomical organization of NMDA, kainate and quisqualate receptors
302. 3H]-l-glutamate binding sites
303. 3H]glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis
304. Factors in the inactivation of postjunctional membrane receptors of frog skeletal muscle
305. Synaptic interactions between mammalian central neurons in cell culture. III. Morphophysiological correlates of quantal synaptic transmission
306. The charge carried out by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics
307. Local anaesthetics transiently block currents through single acetylcholine-receptor channels
308. Synaptic excitation in cultures of mouse spinal cord neurones: receptor pharmacology and behaviour of synaptic currents
309. Pharmacological evidence for synaptic transmission mediated by non-N-methyl-d-aspartate receptors in the avian cochlear nucleus
310. Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells
311. Excitatory and inhibitory actions of ibotenic acid on frog spinal motoneurones in vitro
312. + media: an intracellular study
313. Pharmacological characterization of different types of GABA and glutamate receptors in vertebrates and invertebrates
314. Structural homology of Torpedo californica acetylcholine receptor subunits
315. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
316. N-methyl-d-aspartic, kainic and quisqualic acids evoked currents in mammalian central neurones
317. Divalent cation effects on NMDA-activated channels can be described as Mg-like or Ca-like
318. Magnesium gates glutamate-activated channels in mouse central neurones
319. Cells in the anteroventral cochlear nucleus are insensitive to l-glutamate and l-aspartate; excitatory synaptic responses are not blocked by d-α-aminoadipate
320. Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction
321. Neurotoxicity of excitatory amino acids
322. 3H]-d-AP5 binding sites in rat brain membranes
323. Electrophysiology of mammalian spinal cord in vitro
324. − conductance in cultured spinal cord neurones
325. Structure activity relationships of amino acid receptor sites on an indentifiable cell body in the brain of the land snail Helix aspersa
326. Single glutamate-activated channels in locust muscle
327. Antagonists of synaptic and amino acid excitaion of neurones in the cat spinal cord
328. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
329. Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system
330. 3H]glutamate binding: a new receptor or a particular transport process
331. Induction of swimming in lamprey by L-DOPA and amino acids
332. S-glutamate: its interactions with spinal neurons
333. Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells
334. Stimulus- and amino acid-induced calcium and potassium changes in the rat neocortex
335. Long-term alterations in amino acid-induced ionic conductances in chronic epilepsy
336. The characteristics of synaptic currents and responses to acetylcholine of rat submandibular ganglion cells
337. Two mechanisms for poststimulus hyperpolarization in cultured mammalian neurones
338. Mouse spinal cord in cell culture. III. Neuronal chemosensitivity and its relationship to synaptic activity
339. Junctional mechanisms at group 1a synapses
340. Anaesthetics depress the sensitivity of cortical neurones to l-glutamate
341. Kainic acid produces depolarization of CA3 pyramidal cells in the in vitro hippocampal slice
342. Kynurenic acid as an antagonist of hippocampal excitatory transmission
343. 3H]APB) binding with methyl-substituted APB analogues and glutamate agonists
344. The neurotoxicity of excitatory amino acids is produced by passive chloride influx
345. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
346. Physiology of excitatory synaptic transmission in cultures of dissociated rat hippocampus
347. Role of acetylcholine receptor subunits in gating of the channel
348. Single acetylcholine-activated channels show burst-kinetics in the presence of desensitising concentrations of agonist
349. Excitatory amino acids as transmitter candidates of vibrissae afferent fibres to the rat trigeminal nucleus caudalis
350. Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli
351. Selective activation of synapses near the tip of drug-ejecting microelectrode, and effects of antagonists of excitatory amino acids in the hippocampus
352. 3H-acetylcholine release evoked by excitatory amino acids
353. Postsynaptic firing during repetitive stimulation is required for long-term potentiation in the hippocampus
354. Glutamic acid sensitivity of dendrites in hippocampal slices in vitro
355. Penicilin-induced epileptiform activity in the hippocampal in vitro preparation
356. Properties of a persistent inward current in normal TEA-injected motoneurones
357. Desensitisation and recovery at the frog neuromuscular junction
358. Glutamate antagonists in rat hippocampus
359. The actions of glutamic acid on neurons in the rat hippocampal slice
360. Actions of glutamate and aspartate analogues on rod horizontal and bipolar cells
361. Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells
362. Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain
363. Agonists block current flow through acetylcholine receptor channels
364. Increased resting and evoked release of transmitter following repetitive electrical tetanization in hippocampus: a biochemical correlate to long-lasting synaptic potentiation
365. Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hipocampus
366. 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research
367. An excitatory amino acid antagonist blocks cone input to sign-converting second-order retinal neurons
368. The use of low concentrations of divalent cations to demonstrate a role for N-methyl-d-aspartate receptors in synaptic transmission in amphibian spinal cord
369. Investigations of the effects of glutamate on motoneurons of the isolated frog spinal cord
370. Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: evidence for glutamate as an excitatory transmitter in the rat striatum
371. Negative slope conductance due to a persistent subthreshold sodium current in cat neocortical neurons in vitro
372. Depletion of norepinephrine, but not serotonin, reduces long-term potentiation in the dentate gyrus of rat hippocampal slices
373. Intracellular microelectrode studies of antidromic responses in cortical pyramidal tract neurons
374. Effects of divalent ions and drugs on synaptic transmission in phasic electroreceptors in a Mormyid fish
375. Actions of iontophoretically applied dicarboxylic amino acids and postulated blockers in the red nucleus
376. Excitatory channels operated by quisqualate in crayfish muscle
377. Glutamate activated postsynaptic channels in crayfish muscle investigated by noise analysis
378. Effects of concanavalin A on glutamate operated channels in crayfish muscle
379. Blockade by amino acid antagonists of neuronal excitation mediated by the pyramidal tract
380. Glutamate as the neurotransmitter of cerebellar cells in the cat: electrophysiological evidence
381. Amino acids as neurotransmitters of corticofugal neurones in the rat: a comparison of glutamate and aspartate
382. Repetitive firing of CA1 hippocampal pyramidal cells elicited by dendritic application of glutamate: slow prepotentials and burst-pause pattern
383. Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine
384. Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes
385. Receptor types mediating the excitatory actions of exogenous l-aspartate and l-glutamate in rat olfactory cortex
386. Hippocampal long-term potentiation: mechanisms and implications for memory
387. Recurrent facilitation in cat pyramidal tract cells
388. Intracellular recording from visually identified motoneurons in rat spinal cord slices
389. Antagonism of the baroreceptor reflex by glutamate diethyl ester, an antagonist to l-glutamate
390. Long-term potentiation as a candidate mnemonic device
391. A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate
392. Comparison of responses to transmitter candidates at an N-methylaspartate receptor mediated synapse, in slices of rat cerebral cortex
393. Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular study
394. A N-methyl receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?
395. Neocortical pyramidal cells: a model with dendritic calcium conductance reproduces repetitive firing and epileptic behaviour
396. Calcium-induced long-term potentiation in the hippocampus
397. Pharmacological properties of excitatory neuromuscular synapses in the locust
398. Excitatory amino acid transmitters
399. Criteria for identification of a central nervous system transmitter
400. Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity
401. Glutamate currents in mammalian spinal neurons; resolution of a paradox
402. High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture
403. Pharmacological identification of acetylcholine and glutamate excitatory systems in the dentate gyrus of the rat
404. The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro
405. Glutamate as a transmitter of hippocampal perforant path
406. Hypoglycemia-induced neuronal damage prevented by an N-methyl-d-aspartate antagonist
407. A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro
408. A synaptic potential following single volleys in the hippocampal CA1 region possibly involved in the induction of long-lasting potentiation
409. Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracellulary injected depolarizing current pulses
410. Long-term synaptic enhancement in hippocampus is not regulated by postsynaptic membrane potential
411. Calcium dependency of synaptic long-lasting potentiation in the hippocampal slice
412. Multiple reversal potentials for the action of l-glutamatic acid
413. Ionic blockage of sodium channels in nerve
414. Long-term potentiation in thin hippocampal sections studied by intracellular and extracellular recordings
415. Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus
416. Membrane potential fluctuations associated with glutamate- and homocysteate-induced depolarizations in hippocampal neurons
417. Inhibition and excitation by glutamic acid on cerebellar interneurons
418. + channels of bovine chromaffin cells
419. + channels by external cations
420. Topological mapping of acetylcholine receptor evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide
421. Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentrations in area CA1 of ‘in vitro’ hippocampal slices of rats
422. Cat spinal motoneurones exhibit topographic sensitivity to glutamate and glycine
423. Tetrodotoxin interference of CNS excitation by glutamic acid
424. Actions of glutamic acid on spinal neurones
425. Differentiation between glutamate receptors based on desensitisation