Antitumor Imidazotetrazines. 14. Synthesis and Antitumor Activity of 6- and 8-Substituted Imidazo[5,l-d]-l,2,3,5-tetrazinones and 8-Substituted Pyrazolo[5,l-d]-l,2,3,5-tetrazinones

Journal of Medicinal Chemistry

Volumn 30, Issue 2, 1987, Pages 357-366

  Lunt, Edward ^a   Newton, Christopher G ^a   Smith, Christopher ^a   Stevens, Graham P ^a   Stevens, Malcolm F G ^b   Straw, Colin G ^a   Walsh, Roger J A ^a   Warren, Peter J ^a   Fizames, Christian ^c   Lavelle, Francois ^c   Langdon, Simon P ^b   Vickers, Lisa M ^b  

^a May & Baker Ltd ^*  (United States)

^b ASTON UNIVERSITY   (United Kingdom)

^c SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; IMIDAZO[5,1 D][1,2,3,5]TETRAZIN 4(3H) ONE DERIVATIVE; MITOZOLOMIDE DERIVATIVE; NEW DRUG; PYRAZOLO[5,1 D][1,2,3,5]TETRAZIN 4(3H) ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD AND HEMOPOIETIC SYSTEM; CANCER CHEMOTHERAPY; DRUG ANALYSIS; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSPORT; INFRARED SPECTROPHOTOMETRY; LEUKEMIA L 1210; LYMPHOMA TLX 5; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOKINETICS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERAPY; THYMUS;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG EVALUATION, PRECLINICAL; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; INDICATORS AND REAGENTS; LEUKEMIA L1210; LYMPHOMA; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED STRAINS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0023123974     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00385a018     Document Type: Article

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