Thyroid status influences rat serum but not brain trh pyroglutamyl aminopeptidase activities

Endocrinology

Volumn 120, Issue 3, 1987, Pages 1215-1217

  Emerson, Charles H ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTIRELIN; THYROXINE;

ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN; CENTRAL NERVOUS SYSTEM; CYTOSOL; DOSE TIME EFFECT RELATION; ENDOCRINE SYSTEM; HYPOTHYROIDISM; MEMBRANE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PROTIRELIN PEPTIDASE; RAT; SERUM;

AMINOPEPTIDASES; ANIMAL; BRAIN; CELL MEMBRANE; COMPARATIVE STUDY; CYTOSOL; HYPERTHYROIDISM; HYPOTHYROIDISM; KINETICS; MALE; PYROGLUTAMYL-PEPTIDASE I; RATS; RATS, INBRED STRAINS; SUPPORT, U.S. GOV'T, P.H.S.; THYROID GLAND; THYROIDECTOMY; THYROXINE;

EID: 0023110054     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo-120-3-1215     Document Type: Article

References (14)

1. Wilk S, 1986 Neuropeptide-specific peptidases: Does brain contain a specific TRH degrading enzyme? Life Sciences 39:1487.
2. Taylor WL, Dixon JE 1978 Characteriza tion of a pyroglutamyl aminopeptidase from rat serum that degrades thyrotro pin-releasing hormone. J Biol Chem 253:6934.
3. Bauer K, Nowak P, Kleinkauf H 1981 Specificity of a serum peptidase hydrolyzing thyroliberin at the pyro- glutamyl-histidine bond. Eur J Biochem 118:173.
4. Prasad C, Peterkofsky A 1976 Demonstration of pyroglutamyipeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts. J Biol Chem 251:3229.
5. Bauer K, Kleinkauf H 1980 Catabolism of thyroliberin by rat adenohypophyseal tissue extract. Eur J Biochem 106:107.
6. Busby WH, Youngblood WW, Kizer JS, 1982 Studies of substrate requirements, kinetic properties, and competitive inhibitors of the enzymes catabolizing TRH in rat brain. Brain Res 242:261.
7. Prasad C, Mori M, Pierson W, Wilber JF, Edwards RM 1983 Developmental changes in the distribution of rat brain pyroglutamyl aminopeptidase, a possible determinant of endogenous cyclo His-Pro concentrations. Neurochem Res 8:389.
8. Browne P, O'Cuinn G 1983 An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipepti-dyl amino peptidase, each purified from the soluble fraction of guinea pig brain, in the degradation of thyroliberin in vitro. Eur J Biochem 137:75.
9. O'Connor B, O'Cuinn G 1984 Localization of a narrow-specificity thyroliberin hydrolyzing pyroglutamate aminopeptidase in synaptosomal membranes of guinea pig brain. Eur J Biochem 144:271.
10. Friedman TC, Wilk S 1986 Delineation of a particulate thyrotropin-releasing hormone-degrading enzyme in rat brain by the use of specific inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase. J Neurochem 46:1231.
11. Bauer K 1976 Regulation of degradation of thyrotropin releasing hormone by thyroid hormones. Nature 259:591.
12. White N, Jeffcoate SL, Griffiths EC, Hooper KC 1971 Effect of thyroid status on the thyrotropin-releasing hormone degrading activity of rat J Endocrinol 71:1313.
13. Nogimori T, Alex S, Baker S, Emerson CH 1985 Thyrotropin-releasing hormone metabolism and extraction by the perfused guinea pig placenta. Endocrinology 117:565.
14. Emerson CH, Vogel W, Currie BL 1980 Concentrations of thyrotropin-releasing hormone TRH and deamido-TRH, and TRH deamidase activity in brain. Endocrinology 107:443.