Familial hypersecretion of adrenal androgens transmitted as a dominant, non-hla linked trait

Obstetrics and Gynecology

Volumn 69, Issue 2, 1987, Pages 259-264

  Lee, Peter A ^a,b   Migeon, Claude J ^a,b   Bias, Wilma B ^a,b   Jones, Georgeanna S ^a,b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN;

ADOLESCENT; ADRENAL GLAND; ADULT; AMENORRHEA; AUTOSOMAL INHERITANCE; CLINICAL ARTICLE; CONGENITAL DISORDER; ENDOCRINE SYSTEM; ETIOLOGY; FAMILIAL DISEASE; FEMALE GENITAL SYSTEM; HEREDITY; HIRSUTISM; HUMAN; HYPERSECRETION; MASCULINIZATION; PRIORITY JOURNAL; X CHROMOSOME LINKAGE;

ADOLESCENT; ADRENAL GLAND HYPERFUNCTION; ADULT; AMENORRHEA; CASE REPORT; CHILD; FEMALE; GENES, DOMINANT; HIRSUTISM; HUMAN; LINKAGE (GENETICS); PEDIGREE; PUBERTY, PRECOCIOUS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; X CHROMOSOME;

EID: 0023109899     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Rosenwaks Z, Lee PA, Jones GS, et al: An attenuated form of congenital virilizing adrenal hyperplasia. J Clin Endocrinol Metab 49:335, 1979
2. Migeon CJ, Rosenwaks Z, Lee PA, et al: The attenuated form of congenital adrenal hyperplasia as an allelic form of 21-hydroxylase deficiency. J Clin Endocrinol Metab 51:647, 1980
3. Levine LS, Duponl B, Lorenzon F, et al: Cryptic 21-hydroxylase deficiency in families of patients with classical congenital adrenal hyperplasia. J Clin Endocrinol Metab 51:1316, 1980
4. Levine LS, Dupont B, Lorenzon F, et al: Genetic and hormonal characterization of cryptic 21-hydroxylase deficiency. J Clin Endocrinol Metab 53:1191, 1981
5. Levine LS, Zachmann M, New MI, et al: Genetic mapping of the 21-hydroxylase deficiency gene within the HLA linkage group. N Engl J Med 299:911, 1978
6. Lobo RA, Goebelsmann U: Evidence for reduced 3-β-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome. J Clin Endocrinol Metab 53:394, 1981
7. Zachmann M, Tassinari D, Prader A: Clinical and biochemical variability of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. A study of 25 patients. J Clin Endocrinol Metab 56:222, 1983
8. Gutai JP, Kowarski AA, Migeon CJ: Twenty-four hour integrated concentration of progesterone, 17-hydroxyprogesterone and cortisol in normal male subjects. J Clin Endocrinol Metab 44:116, 1977
9. Lee PA, Rock JA, Brown TR, et al: Leydig cell hypofunction resulting in male pseudohermaphroditism. Fertil Steril 37:675, 1982
10. Beitins IZ, Shaw MH, Kowarski AA, et al: Comparison of competitive protein-binding radioassay of cortisol to double isotope dilution and Porter-Silber methods. Steroids 15:765, 1970
11. Drekter J, Heisler A, Seism CR, et al: The determination of urinary steroids. J Clin Endocrinol Metab 12:55, 1952
12. Silber RH, Porter CC: The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma. J Biol Chem 210:923, 1954
13. Amos DB, Bashir H, Boyle W, et al: A simple microcytotoxicity test. Transplantation 7:220, 1969
14. Byrne GC, Perry YS, Winter JSD: Kinetic analysis of adrenal 3-beta-hydroxysteroid dehydrogenase activity during human development. J Clin Endocrinol Metab 60:934, 1985
15. Rich BH, Rosenfield RL, Lucky AW, et al: Adrenarche: Changing adrenal response to adrenocorticotropin. J Clin Endocrinol Metab 52:1129, 1981
16. Dickerman Z, Grant DR, Faiman C, et al: Intraadrenal steroid concentrations in man: Zonal differences and developmental changes. J Clin Endocrinol Metab 59:1031, 1984
17. Parker LN, Odell WD: Control of adrenal androgen secretion. Endocrinol Rev 1:392, 1980