The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Nature

Volumn 325, Issue 6106, 1987, Pages 733-736

  Kang, Jie ^a   Lemaire, Hans Georg ^a   Unterbeck, Axel ^a   Salbaum, J Michael ^a   Masters, Colin L ^a,b,c   Grzeschik, Karl Heinz ^a,d   Multhaup, Gerd ^a   Beyreuther, Konrad ^a   Müller Hill, Benno ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c ROYAL PERTH HOSPITAL   (Australia)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; MESSENGER RNA; RECEPTOR;

ALZHEIMER DISEASE; BRAIN; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; DOWN SYNDROME; GENETIC ENGINEERING; HEREDITY; HUMAN; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; BASE SEQUENCE; BRAIN; BRAIN CHEMISTRY; CHROMOSOMES, HUMAN, PAIR 21; DNA; DOWN SYNDROME; FETUS; HUMANS; NEUROFIBRILS; NUCLEIC ACID HYBRIDIZATION; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER;

EID: 0023105114     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/325733a0     Document Type: Article

References (31)

1. Alzheimer, A. Allg. Z. Psychiat. 64, 146-148 (1907).
2. Katzman, R. (ed.) Biological Aspects of Alzheimer's Disease (Banbury Report 15) (Cold Spring Harbor Laboratory, New York, 1983).
3. Masters, C. L. et al. Proc natn. Acad. Sci U.S.A. 82, 4245-4249 (1985).
4. Masters, C. L. et al. EMBO J. 4, 2757-2763 (1985).
5. Glenner, G. G. & Wong, C. W. Biochem. biophys. Res. Commun. 120, 1131-1135 (1984).
6. Beyreuther, K. et al. in Discussions in Neuroscience Vol. 3 eds Bignami, A., Bolis, L. & Gajdusek, D. C. 68-79 Fondation pour 1’Etude du Systeme Nerveux, Geneva (1986).
7. Okayama, H. & Berg, P. Molec. cell. Biol. 3, 280-289 (1983).
8. Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 852-862 (1975).
9. Yarden, Y. et al. Nature 323, 226-232 (1986).
10. Geisler, N., Plessmann, U. & Weber, K. FEBS Lett. 182, 475-478 (1985).
11. Lewis, S. A. & Cowman, N. J. Molec. cell. Biol 6, 1529-1534 (1986).
12. Oesch, B. et al. Cell 40, 735-746 (1985).
13. Thomas, P. S. Proc. natn. Acad. Sci U.S.A. 77, 5201-5205 (1980).
14. Southern, E. M. J. molec. Biol 98, 503-517 (1975).
15. Lotscher, E. et al. Nature 320, 456-458 (1986).
16. Gajdusek, D. C. Science 197, 943-960 (1977).
17. Multhaup, G. et al EMBO J. 4, 1495-1501 (1985).
18. Merz, P. A., Sommerville, R. A., Wisniewski, H. M. & Iqbal, K. Acta neuropath. 54, 63-74 (1981).
19. Diringer, H. et al Nature 306, 476-478 (1983).
20. Prusiner, S. B. et al. Cell 35, 349-358 (1983).
21. Liao, Y-C. J., Lebo, R. V., Clawson, G. A. & Smuckler, E. A. Science 233, 364-367 (1986).
22. Goldgaber, D., Lerman, M. L, McBride, W. O, Sallow, V. & Gajdusek, D. C. Science (in the press).
23. Robakis, N. K. et al. Lancet (manuscript in preparation).
24. Bernstein, S. L., Gioco, A. E. & Kaplan, B. B. J. Neurogenet. 1, 71-86 (1983).
25. Aviv, H. & Leder, P. Proc. natn. Acad. Sci U.S.A. 69, 1408-1412 (1972).
26. Woods, D. E., Markham, A. F., Ricker, A. T., Goldberger, G. & Colten, H. R. Proc. natn. Acad. Sci U.S.A. 79, 5661-5665 (1982).
27. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463-5467 (1977).
28. Matteucci, M. D. & Caruthers, M. H. J. Am. Chem. Soc. 103, 3185-3190 (1981).
29. Hewick, R. M., Hunkapiller, M. W., Hood, L. E. & Dreyer, W. J. J. biol Chem. 256, 7990-7997 (1981).
30. Lehrach, H., Diamond, D., Wozney, J. M. & Boedtker, H. Biochemistry 16, 4743-4751 (1977).
31. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237-251 (1977).