Multicellular spheroids - A review on cellular aggregates in cancer research

Journal of Cancer Research and Clinical Oncology

Volumn 113, Issue 2, 1987, Pages 101-122

  Mueller Klieser, Wolfgang ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cellular aggregates; Multicellular spheroids

Indexed keywords

ANTINEOPLASTIC AGENT;

ANIMAL CELL; CANCER RESEARCH; CELL AGGREGATION; HUMAN; HUMAN CELL; HYPERTHERMIA; IN VITRO STUDY; MOUSE; MULTICELLULAR SPHEROID; RAT; REVIEW; TUMOR CELL LINE; TUMOR SPHEROID;

ANIMAL; CELL AGGREGATION; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; EMBRYO; EXTRACELLULAR MATRIX; HUMAN; INTERCELLULAR JUNCTIONS; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; TISSUE CULTURE;

EID: 0023093713     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/BF00391431     Document Type: Editorial

References (293)

1. Microenvironmental conditions in multicellular spheroids grown under liquid-overlay tissue culture conditions
2. Measurements of potassium activities and membrane potentials in tumor cells
3. Electro-physiological measurements in cultured cellular spheroids
4. Methodological aspects of microelectrode measurements in cellular spheroids
5. Glycosaminoglycan synthesis by mammary tumor spheroids
6. Isolation of quiescent cells from multicellular tumor spheroids using centrifugal elutriation
7. Gap junctions and development
8. Cellular kinetics of invasive squamous carcinoma of the human cervix
9. A cell surface molecule involved in aggregation of embryonic liver cells
10. The effect of nitrobenzene derivatives on oxygen utilization and radiation response of an in vitro tumor model
11. The enhanced radiation response of an in vitro tumor model by cyanide released from hydrolysed amygdalin
12. Interactions between mizonidazole, hyperthermia and some cytotoxic drugs on multicellular tumour spheroids
13. The effect of prolonged hypoxia on growth and viability of chinese hamster cells
14. Adhesion among neural cells of the chick embryo. I. An immunologic assay for molecules involved in cell-cell binding
15. Changes of histological and proliferative indices in the Walker carcinoma with tumour size and distance from blood vessel
16. Inhibition of tumor angiogenesis mediated by cartilage
17. The use of multicellular spheroids in establishing human sarcoma cell lines in vitro
18. The Gompertz equation and the construction of tumour growth curves
19. On the existence of a G0-phase in cycle
20. A proliferation gradient in three-dimensional colonies of cultured human glioma cells
21. Influence of oxygen pressure in the culture medium on the oxygenation of different types of multicellular spheroids
22. The influence of oxygen on viability and proliferation in cellular spheriods
23. Mitogenicity of brain axolemma membranes and soluble factors for dorsal root ganglion Schwann cells
24. A marker for hypoxic cells in tumours with potential clinical applicability
25. Tumor cell suspension culture on non adhesive substratum
26. Multicellular tumour spheroids: a model for combined in vivo/in vitro assay of tumour immunity
27. An in vitro assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents
28. Observations on the histoformative capacities of tumor cells dissociated by digestion with trypsin
29. Some observations in the three-dimensional growth of L5178Y cell colonies in soft agar culture
30. Cell cycle-specific effects of tumor necrosis factor
31. In vitro and in vivo labelling of animal tumours with tritiated thymidine
32. Kinetics of regrowth of V79 spheroids after irradiation and negative pion-irradiation
33. Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction
34. Intercellular communication in spheroids
35. A comparative study of post-irradiation growth kinetics of spheroids and monolayers
36. Split-dose survival and cycle progression of proliferating and non-proliferating cells in V79 spheroids
37. Recovery and cycle progression in multicell spheroids after fractionated gamma-irradiation and combined hyperthermia treatment
38. Negative pion irradiation of mammalian cells. 1. Survival characteristics of monolayers and spheroids of Chinese hamster lung cells
39. Intercellular communication, three-dimensional cell contact and radiosensitivity
40. Is there a relationship between hypoxia, contact resistance, and intercellular communication?
41. Relationship between intercellular communication and radiosensitivity of human tumor xenografts
42. Cell-cell contact affects cellular sensitivity to hyperthermia
43. Three-dimensional pattern generation applied to spheroidal tumor growth in a nutrient medium
44. Cure, regression and cell survival: a comparison of common radiobiological endpoints using an in vitro tumor model
45. Isolation of cell subpopulations from in vitro tumor models according to sedimentation velocity
46. Time-dose relationship in an in vitro tumor model
47. Cell cycle kinetics in an in vitro tumor model
48. Effects of hyperthermia on the cycling, noncycling, and hypoxic cells of irradiated and unirradiated multicell spheroids
49. Variable radiobiological responses of spheroids
50. Oxygen enhancement ratio in V79 spheroids
51. Cellular oxygen utilization and radiation response of V79 spheroids
52. Letter: Modification of the radiation response of an in vitro tumor model by control of cellular respiration
53. Radiosensitization of hypoxic cells of an in vitro tumor model by respiratory inhibitors
54. Effects of lucanthone on Chinese hamster V79 cells. I. Interaction with radiation in monolayers and spheroids
55. Combination adriamycin/misonidazole toxicity in V79 spheroids
56. Fast neutron effects on multicell spheroids
57. Radiation-induced DNA damage in V79 spheroids and monolayers
58. Evaluation of nitroheterocyclic radiosensitizers using spheroids
59. Enhanced survival of Chinese hamster V-79 cells grown and irradiated as multicellular spheroids
60. Effects of intercellular contact on repair of radiation damage
61. Dependence of the radiation response of an in vitro tumor model on cell cycle effects
62. Growth and radiation survival characteristics of V-79-171b Chinese hamster cells: a possible influence of intercellular contact
63. Repair and reoxygenation following irradiation of an in vitro tumor model
64. Radiation studies with spheroids
65. Cell adhesion molecules
66. Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice
67. Chemosensitivity measurements of human tumor cells by soft agar assays are influenced by the culture conditions
68. Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids and xenografts in immune-deprived mice
69. Radiation-biological investigations with multicellular spheroids as an in vitro tumor model. VIII. Comparative investigations of the growth behavior of V-79-4 multicellular spheroids after irradiation with cesium-rays, x-rays, fast neutrons, negative pions and heavy ions
70. Tumor angiogenesis: therapeutic implications
71. Tumor angiogenesis factor
72. Tumor angiogenesis
73. Influence of geometry on growth of normal and malignant cells
74. Self-regulation of growth in three dimensions
75. Self-regulation of growth in three dimensions: the role of surface area limitation
76. Hypoxic fraction and binding of misonidazole in EMT6/Ed multicellular tumor spheroids
77. Binding of 14C-misonidazol to hypoxic cells in V79 spheroids
78. The radiation response of hypoxic cells in EMT6 spheroids in suspension culture does model data from EMT6 tumours
79. Binding of misonidazole to V79 spheroids and fragments of Dunning rat prostatic and human colon carcinomas in vitro: diffusion of oxygen and reactive metabolites
80. Rate of death of hypoxic cells in multicell spheroids
81. Oxygen diffusion distance and development of necrosis in multicell spheroids
82. Radiation survival of cells from spheroids grown in different oxygen concentrations
83. Binding of misonidazole to EMT6 and V79 spheroids
84. Selective dissociation and characterization of cells from different regions of multicell tumor spheroids
85. A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth
86. In situ oxygen consumption rates of cells in V-79 multicellular spheroids during growth
87. Regulation of growth saturation and the development of necrosis in multicell spheroids by the oxygen and glucose supply
88. Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells
89. Radiobiological studies of cells in multicellular spheroids using a sequential trypsinizing technique
90. Tumor dormancy in vivo by prevention of neovascularization
91. Cell recognition: phenomena in search of molecules
92. Models for the growth of a solid tumor by diffusion
93. Epithelial layer formation in differentiating aggregates of F9 embryonal carcinoma cells
94. Further evidence for the absence of a hypoxic fraction in the 9-L rat tumor multicellular spheroid system
95. Differences in patterns of aggregation of malignant and non-malignant mammalian cells
96. Primary bioassay of human tumor stem cells
97. Radiation biological investigations with multicellular spheroids as an in vitro tumor model. IX. Estimation of DNA double-strand break rates of spheroid cells after x-ray irradiation of spheroids
98. A simple method for cloning and replica plating of mammalian cells using multicellular spheroids
99. Proliferation and viability in cellular spheroids of human origin
100. Factors mediating cell-cell recognition and adhesion. Galaptins, a recently discovered class of bridging molecules
101. Immunologic detection of retina cognin on the surface of embryonic cells
102. Radioresistance of anoxic cells and the effects of PNAP on the radiation response of an in vitro tumor model
103. Repair of potentially lethal damage in x-irradiated V79 cells
104. Indirect sensitization by drug induced reoxygenation in spheroids
105. Radiation sensitivity modification by chemotherapeutic agents
106. Increased radio resistance of cells in cultured multicell spheroids. II. Kinetic and cytogenetic studies
107. Two-dimensional diffusion limited system for cell growth
108. A study of the mechanics of gastrulation
109. Neural induction in explants which have passed through a sublethal cytolysis
110. Biochemical differentiation in aggregating cell cultures of different fetal brain regions
111. Differential response of elutriated 9L cells to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea
112. Ionic coupling between non-excitable cells in culture
113. Relation between ionic coupling and morphology of established cells in culture
114. Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture
115. Inter- and intratissue communication during amphibian development
116. Gap junction formation between reaggregated Novikoff hepatoma cells
117. Correlation of the growth of Chinese hamster V79-171b multicellular spheroids with cytokinetic parameters
118. In vitro cytotoxic drug sensitivity testing of human tumour xenografts grown as multicellular tumour spheroids
119. Growth delay in 9L rat brain tumor spheroids after irradiation with single and split doses of x-rays
120. Advantage of reduced oxygen tension in growth of human melanoma in semi-solid cultures: quantitative analysis
121. A system for determining the pharmacology of indirect radiation sensitizer drugs on multi-cellular spheroids
122. Patterns of tumor colony development over time in soft-agar culture
123. Response of multicellular tumor spheroids to multiple fractions of negative pi mesons and x-rays
124. The effect of hypoxia on the generation time of mammalian cells
125. Radiation-biological investigations with multicellular spheroids as an in vitro tumor model. II. Cell contact modelled by small multicellular spheroids enhances cell survival and DNA single-strand break rejoining
126. Radiation-biological investigations with multicellular spheroids as an in vitro tumor model. I. Growth of multicell spheroids
127. Radiation-biological investigations with multicellular spheroids as an in vitro tumor model. III. Comparative investigations of single cell survival after irradiation of V-79-4 multicellular spheroids with x-rays or fast neutrons
128. Radiation-biological investigations with multicellular spheroids as an in vitro tumor model. IV. Comparative investigations of volume changes and repopulation of intact V-79-4 multicellular spheroids after irradiation with x-rays or fast neutrons
129. Time-lapse studies of growth-behavior and radiation response of multicellular spheroids—preliminary results
130. Multicellular spheroids as an in vitro model for investigation of cell-cell interaction, tumour irradiation response and possibility of the mechanism of metastasation
131. Multicellular spheroids as an in vitro model for the investigation of cell-cell interaction
132. Volume changes of multicellular spheroids after irradiation with x-rays
133. Radiation response of HMV-1 human malignant melanoma cells grown in vitro as multicellular spheroids
134. The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs—an in vitro study using EMT6 multicellular spheroids
135. The response to cytotoxic drugs of EMT6 cells, treated either as intact or disaggregated spheroids
136. Regulatory mechanisms in spheriodal aggregates of normal and cancerous cells
137. Shedding of mitotic cells from multicellular spheroids during growth
138. A model for the growth of multicellular spheroids
139. In vivo growth of tumor cell spheroids after in vitro hyperthermia
140. Spheroidal aggregate culture of rat liver cells: histotypic reorganization. biomatrix deposition, and maintenance of functional activities
141. Multicellular tumor spheroids of human colon carcinoma origin: kinetic analysis of infiltration and in situ destruction in a xenogeneic(murine)host
142. Binding of isolated 3T3 surface membranes to growing 3T3 cells and their effect on cell growth
143. Thyrotropin-induced aggregation and reorganization into follicles of isolated porcine-thyroid cells. 1. Mechanism of action of thyrotropin and metabolic properties
144. Gap junctional communication in the pre-implantation mouse embryo
145. Gap junctional communication in the post-implantation mouse embryo
146. Junctional intercellular communication: the cell-to-cell membrane channel
147. Intercellular communication and tissue growth. I. Cancerous growth
148. Comparison of in situ and peripheral host immunity to syngeneic tumours employing the multicellular spheroid model
149. Assessment of in situ host immunity of syngeneic tumors utilizing the multicellular model
150. The multicellular tumor spheroid model. II. Characterization of the primary allograft response in unsensitized mice
151. Morphological and functional characteristics of cells infiltrating and destroying tumor multicellular spheroids in vivo
152. The multicellular tumor spheroid model. I. Characterization of the secondary allograft response in sensitized mice
153. Kinetic response of an in vitro “tumour model” (V-79 spheroids) to 42° C hyperthermia
154. Survival and kinetic response of V-79 spheroids after exposure to heavy ion beams
155. Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro fed plateau monolayers
156. The multicellular spheroid as a model tumor allograft. 1. Quantitative assessment of spheroid destruction in alloimmune mice
157. The multicellular tumor spheroid: a quantitative model for studies of in situ immunity
158. The multicellular spheroid as a model tumor allograft. II. Characterization of spheroid-infiltrating cytotoxic cells
159. Recent aspects of tumour invasiveness
160. the use of embryo organ culture to study invasion in vitro
161. Methods of study of the invasion of malignant C3H-mouse fibroblasts into embryonic chick heart fragments in vitro
162. Grafting of HeLa cells in young chick blastoderms
163. Aggregating brain cell cultures: a model to study brain development
164. Colonial growth in agar of cells derived from adenovirus-induced hamster tumors
165. Apoptosis as a volume loss mechanism in mathematical models of solid tumor growth
166. A model for the growth of a solid tumor with non-uniform oxygen consumption
167. Differential cytotoxicity of cis-platinum and blenoxane against human carcinoma KBE cells in multicellular spheroids of different ages: response at different temperatures
168. Invasion of malignant C3H mouse fibroblasts from aggregates transplanted into the auricles of syngeneic mice
169. Infiltration of lymphosarcoma cells into hepatocyte cultures: inhibition by univalent antibodies against liver plasma membranes and lymphosarcoma cells
170. Effect of salt solution on the radiosensitivity of mammalian cells as a function of the state of adhesion and the water structure
171. Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs
172. Interactions between misonidazole and hyperthermia in EMT6 spheroids
173. Cell suspensions from organ rudiments of chick embryos
174. Formation of lentoids by dissociated retinal cells of the chick embryo
175. The development in vitro of chimeric aggregates of dissociated embryonic chick and mouse cells
176. Rotation-mediated histogenic aggregation of dissociated cells
177. Microelectrode measurement of oxygen tension distributions in multicellular spheroids cultured in spinner flasks
178. Method for determination of oxygen consumption rates and diffusion coefficients in multicellular spheroids
179. Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids
180. Oxygen tensions in multicell spheroids of two cell lines
181. Oxygen consumption and oxygen diffusion properties of multicellular spheroids from two different cell lines
182. Evidence for a major role of glucose in controlling development of necrosis in EMT6/Ro multicell tumor spheroids
183. Changes in O2 consumption of multicellular spheroids during development of necrosis
184. Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids
185. the growth and morphology of FRTL-5 thyroid epithelial cells grown as multicellular spheroids in vitro
186. Growth of tumour cells as multicellular spheroids and antitumour drug evaluations
187. Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids
188. Penetration of substances into tumor tissue — a methodological study on cellular spheroids
189. Demonstration of an extracellular matrix in multicellular tumor spheroids
190. Cell-cell adhesion in the embryonic chick: partial purification of liver adhesion molecules from liver membranes
191. Complete sequence and transcript regulation of a cell adhesion protein from aggregating dystyostelium cells
192. Intercellular adhesion of rat hepatocytes. Identification of a cell surface glycoprotein involved in the initial adhesion process
193. Different sensitivity to cytotoxic agents of internal and external cells of spheroids composed of thioguanine-resistant and sensitive cells
194. Cell contact during expression of radiation mutation in Chinese hamster V-79 spheroids
195. Activation of radiosensitizers by hypoxic cells
196. Uptake and mutagenicity of AF-2 in Chinese hamster V-79 spheroids under aerobic and hypoxic conditions
197. Development of tetraploidy in V-79 spheroids
198. Long-term culture of pancreatic islet cells with special reference of the B-cell function
199. Inhibition of DNA synthesis in SV3T3 cultures by isolated 3T3 plasma membranes
200. Relationship between surviving fractions using the colony methods, the LD50, and the growth delay after irradiation of human melanoma cells grown as multicellular spheroids
201. In vitro studies of cell proliferation in tumors II
202. Binding of misonidazole to hypoxic cells in monolayer and spheroid culture. Evidence that a side-chain label is bound as efficiently as a ring label
203. Comparison of binding of H3-misonidazole and C14-misonidazole in multicell spheroids
204. Cell survival in spheroids irradiated with heavy-ion beams
205. Feeder cells and cell survival in spheroids and monolayers
206. Heat response of human melanoma multicellular spheroids: comparison with single cells and xenografted tumors
207. Influence of growth conditions and cell-cell contact on responses of tumor cells to ultrasound
208. Response of multicell spheroids to 1 MHz ultrasonic irradiation: cavitation related damage
209. Preparation of permanent slides of intact soft agar colony cultures of hematopoietic and tumor stem cells
210. Factors that influence initiation and growth of 9L rat brain gliosarcoma multicellular spheroids
211. the relative resistance of non-cyclic cells in 9L multicellular spheroids to Spirohydantoin Mustard
212. Effects of alphadifluoromethylornithine on the growth of 9L rat brain tumor multicellular spheroids and their response to 1,3-bis(2-chloroethyl)-1-nitrosourea
213. Response of 9L rat brain tumor multicellular spheroids to single and fractionated doses of 1,3-bis(2-chloroethyl)-1-nitrosourea
214. Lethal effect of bleomycin and peplomycin on HeLa cells in multicell tumor spheroids
215. Development of multicellular spheroids of HeLa cells cocultured with fibroblasts and their response to x-irradiation
216. Studies on aggregation of human ascites tumor cells
217. The confrontation of normal and malignant cells in vitro. An experimental system in tumor invasion studies
218. the confrontation of normal tissue and malignant cells in vitro-human decidua graviditatis and HeLa cells. A model for studies on tumor invasion
219. Interaction of human carcinoma cells with an epithelial layer and the underlying basement membrane. A new model
220. Ultrastructural and functional characteristics of rat pituitary cell aggregates
221. Differentiation of aggregating brain cell cultures
222. Radiosensitivities of murine lymphoma L5178Y cells in a multi-cellular colony system
223. Cytotoxic effect of 5-thio- d-glucose on chronically hypoxic cells in multicell spheroids
224. Elimination of hypoxic protection by 5-thio- d-glucose in multicellular spheroids
225. The multicellular spheroid as a model tumor allograft. III. Morphological and kinetic analysis of spheroid infiltration and destruction
226. Hyperthermic potentiation of cytotoxicity of R0-07-0582 in multicell spheroids
227. Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model
228. Cytotoxicity of glucose analogs in V-79 multicellular spheroids
229. Effect of anticancer agents on directional migration of malignant C3H mouse fibroblastic cells in vitro
230. Influence of anticancer agents on growth, migration and invasion of malignant fibroblastic cells
231. Enhanced recovery from growth inhibition in irradiated MO4 spheroids invading into embryonic chick heart fragments in organ culture
232. Recovery from growth inhibition in irradiated MO4 spheroids: suspension cultures versus explanted cultures
233. Aggregative performance
234. Selective chemotherapy of noncycling cells in an in vitro tumor model
235. Cytotoxicity of hypoxic cell sensitizers in multicellular spheroids
236. Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model
237. Hypoxic cells in an in vitro tumour model
238. Radiation effects on mammalian cells grown as an in vitro tumor model
239. Cytotoxicity of radiosensitizers in multicell spheroids: Combination treatment with hyperthermia
240. Cytotoxicity of hyperthermia plus the radiosensitizer Ro-07-0582 in multicell spheroids
241. A multicomponent radiation survival curve using an in vitro tumour model
242. Growth of multicellular spheroids in tissue culture as a model of nodular carcinomas
243. Modification by TAN of the radiation response of Chinese hamster cells grown as a tumor model
244. Multicellular spheroids: a new model target for in vitro studies of immunity to solid tumor allografts
245. Resistance to adriamycin in multicellular spheroids
246. Cytotoxicity of hypoxic cell sensitizers in multicell spheroids
247. Spheroids in cancer research
248. Oxygenation and differentiation in Multicell spheroids of human colon carcinoma
249. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumor
250. Can cell morphology in monolayer reveal its behaviour in aggregates?
251. Two chick embryonic adhesion systems: molecular vs tissue specificity
252. The histological structure of some human lung cancers and the possible implications for radiotherapy
253. Differential survival of cell subpopulations in spheroids after treatment with bleomycin
254. Effect of cell-cell interaction in drug sensitivity and growth of drug-sensitive and-resistant tumor cells in spheroids
255. Detection of heterogeneity in the chemosensitivity of 9L brain tumor cell lines to 1,2-bis(2-chloroethyl)-1-nitrosourea by the sister chromatid exchange assay
256. Fractionated irradiation with x-rays and fast neutrons — response of V-79-4 multicellular spheroids as an in vitro tumor model
257. Influence of oxic and extremely hypoxic conditions on the recovery of sublethal radiation damage in small multicellular spheroids of Chinese hamster cells
258. Morphological differentiation of mechanically dissociated fetal rat brain in aggregating cell cultures
259. Experimental chemotherapy studies. intercomparison of assays
260. Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival
261. Growth delay in small EMT6 spheroids induced by cytotoxic drugs and its modification by misonidazole pretreatment under hypoxic conditions
262. In vitro pre-incubation with misonidazole under hypoxic conditions: effect on drug response of EMT6 spheroids
263. Transfer of tumor cells between cell aggregates as a model for adhesive changes in metastasis
264. Cell-cell adhesion molecules: Identification of a glycoprotein relevant to the Ca2+-independent aggregation of Chinese hamster fibroblasts
265. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma
266. Biological effects of negative pions in monolayers and spheroids of Chinese hamster cells
267. The structure and function of intercellular junctions in cancer
268. Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy
269. the radiation response of V79 and human tumour multicellular spheroids-cell survival and growth delay studies
270. Resistance to vincristine of human cells grown as multicellular spheroids
271. A study of factors related to the action of 1-proparagyl-5-chloropyrimidin-2-one(NY 3170) and vincristine in human multicellular spheroids
272. Cell kinetic characteristics in different parts of multicellular spheroids of human origin
273. Multicellular spheroids grown directly from human tumour material
274. Increased thermoresistance developed during growth of small multicellular spheroids
275. Activity of 4-(9-acridinylamino)methanesulfon-m-anisidide against Chinese hamster cells in multicellular spheroids
276. Teratocarcinoma cell adhesion: identification of a cell-surface protein involved in calcium-dependent cell aggregation
277. Growth fraction as the major determinant of multicellular tumor spheroid growth rates
278. In vitro studies on radioresistance of oxic and hypoxic cells in presence of both radioprotective and radiosensitizing drugs
279. Dormany and spontaneous recurrence of human breast cancer in vitro
280. A simplified method for production and growth of multicellular tumor spheroids
281. Multicellular tumor spheroid formation by breast cancer cells isolated from different sites
282. Tumor line dependent interactions of irradiation and cis-diamminedichloroplatinum in the multicellular tumor spheroid system
283. Quantitation of the response of human tumor spheroids to daily radiation exposures