The effect of a topical tricyclic antihistamine on the response of the nasal mucosa to challenge with cold, dry air and histamine

The Journal of Allergy and Clinical Immunology

Volumn 79, Issue 4, 1987, Pages 599-604

  Togias, A ^a   Proud, D ^a   Kagey Sobotka, A ^a   Norman, P ^a   Lichtenstein, L ^a   Naclerio, R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATADINE; HISTAMINE; PLACEBO;

ALLERGIC RHINITIS; CLINICAL ARTICLE; DRUG EFFICACY; DRUG MECHANISM; DRUG THERAPY; HISTAMINE RELEASE; HUMAN; INTRANASAL DRUG ADMINISTRATION; MAST CELL; NOSE MUCOSA; OLFACTORY SYSTEM; PRIORITY JOURNAL; THERAPY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; COLD; CYPROHEPTADINE; FEMALE; HISTAMINE; HUMANS; HUMIDITY; MALE; NASAL MUCOSA; PLACEBOS; RHINITIS, ALLERGIC, PERENNIAL;

EID: 0023091976     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(87)80155-0     Document Type: Article

References (12)

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3. Demonstration of inhibition of mediator release from mast cells by azatadine base: in vivo and in vitro evaluation
4. An in vivo model for the evaluation of topical antiallergic medications
5. Nasal challenge with cold, dry air results in release of inflammatory mediators: possible mast cell involvement
6. Local generation of sulfidopeptide leukotrienes upon nasal provocation with cold, dry air
7. Mediator release after airway challenge with allergen
8. Influx of kininogens into nasal secretions following antigen challenge of allergic individuals
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10. Interaction between hyperosmolar and IgE-induced histamine release from basophils and mast cells
11. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine
12. 2 receptors in the human nose: rationale for topical use of combined antihistamine preparations