Tumor hypoxia: its impact on cancer therapy

Cancer and Metastasis Reviews

Volumn 5, Issue 4, 1987, Pages 313-341

  Moulder, John E ^a   Rockwell, Sara ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

chemotherapy; experimental tumors; hypoxic cells; oxygenation; radiation resistance; radiotherapy

Indexed keywords

OXYGEN;

ANIMAL; CANCER TRANSPLANTATION; CELL DIVISION; CELL SURVIVAL; DNA REPAIR; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; RADIATION DOSE; REVIEW; XENOGRAFT;

ANIMAL; CELL DIVISION; CELL SURVIVAL; DNA REPAIR; HUMAN; NEOPLASM TRANSPLANTATION; NEOPLASMS; OXYGEN; RADIATION TOLERANCE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSPLANTATION, HETEROLOGOUS;

EID: 0023082510     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00055376     Document Type: Article

References (242)

1. The action of radium on cancer cells. II. — Some factors determining the sensitivity of cancer cells to radium
2. On the alteration in the sensitivity of cells towards radiation produced by cold and anaerobiosis
3. A factor of importance in the radiosensitivity of tumours
4. The histological structure of some human lung cancers and the possible implications for radiotherapy
5. Evidence for acutely hypoxic cells in mouse tumors, and a possible mechanism of reoxygenation
6. A multi-component X-ray survival curve for mouse lymphosarcoma cells irradiated in vivo
7. The phenomena of reoxygenation and its implications for fractionated radiotherapy
8. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data
9. The hypoxic tumor cell: a target for selective cancer chemotherapy
10. Hypoxic cells as targets for cancer chemotherapy
11. Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
12. A rapid method for studying tumour blood supply using systemic dyes
13. On the access of blood-borne dyes to various tumour regions
14. A rapid method for studying tumour blood supply using lissamine green
15. Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions
16. Comparative chemosensitivity of exponential-versus plateau-phase cells both in vitro and in vivo
17. Proliferation-dependent cytotoxicity of anticancer agents: A review
18. The effect of hypoxia on the growth and radiation response of mammalian cells in culture
19. Kinetic heterogeneity in density-separated murine fibrosarcoma subpopulations
20. Plateau phase in growth induced by hypoxia
21. Exploitation of the oxygen enhancement ratio in clinical practice
22. La Ronde — radiation sciences and medical radiology
23. Modification of radiation response
24. Reoxygenation and its potential role in radiotherapy
25. Unconventional fractionation in clinical radiotherapy
26. Preliminary results of bladder carcinoma irradiated with low individual doses and a high total dose
27. Oxygenation in radiotherapy. II. Clinical applications
28. Hyperbaric oxygen: the Medical Research Council trials and their clinical significance
29. ‘Oxygen effect’ and tumor size as related to response of C3H/Ba adenocarcinoma to local X-irradiation
30. The effect of carbogen on the response of spontaneous tumors in mice to radiotherapy
31. The effect of oxygen breathing and radiotherapy upon the tissue oxygen tension of some human tumours
32. Effect of duration of breathing 95% oxygen plus 5% carbon dioxide before X-irradiation on the cure of C3H mammary tumor
33. Carbogen breathing during radiation therapy
34. Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor
35. A clinical trial of Fluosol DA 20% in advanced squamous cell carcinoma of the head and neck
36. Perfluorochemical emulsions can increase tumor radiosensitivity
37. Prognostic factors of radiation therapy with metronidazole of cervix cancer
38. Definitive evidence for hypoxic cells influencing cure in cancer therapy
39. Primary radiotherapy of larynx and pharynx carcinoma — An analysis of some factors influencing local control and survival
40. Monitored regional hypoxia in radiotherapy
41. Radiation therapy given under conditions of local hypoxia for bone and soft tissue sarcoma
42. Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole
43. Is tumor radiosensitization by misonidazole a general phenomena?
44. Misonidazole as an adjuvant to radiotherapy in the treatment of invasive carcinoma of the larynx and pharynx
45. In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique
46. Radiation and high dose metronidazole in supratentorial glioblastomas
47. Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays. I. Effects of single exposures
48. Biological basis for high-LET radiotherapy
49. Will hyperthermia conquer the elusive hypoxic cell?
50. Effect of hyperthermia on the hypoxic fraction of an experimental mammary carcinoma in vivo
51. Tumour cords in 52 human bronchial and cervical squamous cell carcinomas: Inferences for their cellular kinetics and radiobiology
52. Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy
53. Oxygen tension in human tumors: in vivo mapping using CT-guided probes
54. Intracapillary oxyhemoglobin saturation in malignant tumors in humans
55. Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia
56. Chemical sensitizers for hypoxic cells
57. Effectiveness and biological effects of techniques used to induce hypoxia in solid tumors
58. Simple linear regression
59. Maintenance of tumor systems and appropriate treatment techniques
60. The effect of pentobarbital anaesthesia on the radiosensitivity of four mouse tumors
61. Hypoxic fraction determinations with the BA1112 rat sarcoma: Variation within and among assay techniques
62. The effect of anesthetics on the radiosensitivity of a murine tumor
63. Radioprotection by pentobarbitone sodium of a murine tumor in vivo
64. Evidence for unconventional radiosensitivity of rat 9L subcutaneous tumors
65. Oxygen washout studies in the anesthetized dog
66. A new method of determining the fraction of hypoxic cells in a transplantable murine sarcoma
67. Quantitative radiosensitivity studies of solid carcinomas in vivo: Methodology and effect of anoxia
68. Vascular occlusion and tumor cell death
69. Demonstration of an anoxic component in a mouse tumor-cell population by an in vivo assay of survival following irradiation
70. Oxygen diffusion and the distribution of cellular radiosensitivity in tumors
71. Tumor-to-tumor variability in the hypoxic fractions of experimental rodent tumors
72. In vivo observations of tumor blood flow
73. Reoxygenation of tumours in ‘sandwich’ chambers
74. Oxygenation and reoxygenation in ‘sandwich’ tumors
75. On the nature of the radiobiologically hypoxic fraction in tumors
76. Repair of sublethal radiation injury in hypoxic cells of a C3H mouse mammary carcinoma
77. Hypoxia and reoxygenation in the KHT sarcoma
78. Tumor control and normal tissue tolerance in fractionated low dose rate radiotherapy
79. The inactivation of Chinese hamster cells by X-rays: Synchronized and exponential cell populations
80. The shape of radiation survival curves of mammalian cells cultured in vitro
81. Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia
82. Cell-cycle distributions and radiation responses of Chinese hamster cells cultured continuously under hypoxic conditions
83. The effect of hypoxia on the repair of sublethal radiation damage in cultured mammalian cells
84. The effect of extreme hypoxia and glucose on the repair of potentially lethal and sublethal radiation damage in mammalian cells
85. Radiation response of cell populations irradiated in situ and separated from a fibrosarcoma
86. Repair of radiation damage in Lewis Lung carcinoma cells following in situ treatment with fast neutrons and gamma rays
87. Characterization of cell suspensions from solid tumors
88. The statistics of dose/cure relationships for irradiated tumors
89. The steepness of the dose-response curve in radiation therapy
90. Significance of the slope of curves of tumor control versus radiation dose
91. Tumor response endpoints in the BA1112 rat sarcoma
92. Direct analysis of tumor control data
93. Dose-response curve and split-dose recovery in human skin cancer
94. Radiobiological studies of tumours in situ compared with cell survival
95. The effect of recovery from potentially lethal damage on the determination of repair and repopulation in a murine tumour
96. Cellular and molecular repair of x-ray induced damage: Dependence on oxygen tension and nutritional status
97. The effect of prolonged hypoxia on growth and viability of Chinese hamster cells
98. Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: Potential implications for cell death in tumors
99. Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vivo
100. A comparison of the effect of radiation on tumour growth delay and cell survival. The effect of oxygen
101. Principles and practices of the tumor growth delay assay
102. Stromal radiosensitivity: influence of tumour type on the tumor bed effect assay
103. The growth of transplanted murine tumors in pre-irradiated sites
104. Modification of tumor response to cyclophosphamide and irradiation by preirradiation of the tumor bed
105. Split dose recovery of a mouse tumor and its stroma during fractionated irradiation
106. Assessment of tumour response in a rat rhabdomyosarcoma
107. The gross response of an experimental tumour to single doses of X-rays
108. Effects of irradiation by single or multiple fractions per day on a transplantable murine mammary carcinoma
109. A low oxygen-enhancement ratio for tumour-cell survival as compared with that for tumour-growth delay
110. The response of C3H mammary tumours to irradiation in single and fractionated doses
111. Is cell survival a determinant of the in situ response of 9L tumors
112. Cellular radiosensitivity of a rat brain tumor
113. The change in hypoxic and chronically hypoxic cell fraction in murine tumors treated with hyperthermia
114. The effect of radiation on tumour growth delay, cell survival and cure of animals using a single tumour system
115. A comparison of the effects of radiation on tumour growth delay and cell survival. The effect of radiation quality
116. Response of EMT-6 tumors to single fractions of X-rays and cyclotron neutrons: Evaluation and comparison of multiple endpoints
117. Comparison of growth delay and cell survival as end-points of tumour response following treatment with combinations of cytotoxic agents
118. Experimental chemotherapy studies: intracomparison of assays
119. Recovery from sublethal damage by acutely hypoxic tumor cells in vivo and in vitro
120. Quantitative evaluation of the radiosensitivity of cells of a transplantable rhabdomyosarcoma in the rat
121. The effect of anaemia on the fraction of hypoxic cells in an experimental tumour
122. Oxygenation status of a transplantable tumor during fractionated radiation therapy
123. Influence of in vitro assay conditions on the assessment of radiobiological parameters of the MT tumour
124. Comparison of tumor assay methods
125. Biological properties and response to X-rays of first generation transplants of spontaneous mammary carcinomas in C3H mice
126. Modification of the radiocurability of a syngeneic murine squamous carcinoma by its site of growth, by electron-affinic drugs, and by ICRF 159
127. Radiosensitivity of lymph node metastases versus initial subcutaneous tumors in nude mice
128. Reoxygenation in the RIF-1 tumor
129. Reoxygenation of the RIF-1 tumor after fractionated radiotherapy
130. Effects of sodium pentobarbital on the radiation response of EMT6 cells in vitro
131. Effect of tumor blood flow manipulations on radiation response
132. The radiation sensitivities of R3327-H and R3327-AT rat prostate adenocarcinomas
133. The choice of animal tumors for experimental studies of cancer therapy
134. A critique of the evidence for active host defense against cancer, based on personal studies of 27 murine tumours of spontaneous origin
135. Satisfactory and unsatisfactory tumor models: Factors influencing the selection of a tumor model for experimental evaluation
136. Oxygenation and reoxygenation of a mouse carcinoma
137. Cellular radiosensitivity and tumor radiation response in the EMT6 tumor cell system
138. The relative effects of fast neutrons and X-rays on tumours and normal tissue in the rat. Part II. Fractionation: recovery and reoxygenation
139. Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after irradiation
140. Cell survival in rat rhabdomyosarcoma tumors irradiated in vivo with extended-peak silicon ions
141. In vivo cell survival and volume response characteristics of rat rhabdomyosarcoma tumors irradiated in the extended peak region of Carbon- and Neon-ion beams
142. In vivo-in vitro tumor cell lines: Characteristics and limitations as models for human cancer
143. Hypoxic fractions and repair of potentially lethal radiation damage in two human melanomas transplanted into nude mice
144. Radiation response of two human malignant melanomas grown in athymic nude mice
145. Radiosensitivity of four human tumor xenografts. Influence of hypoxia and cell-cell contact
146. Survival curve of a human melanoma in nude mice
147. Radiation response of the cells of a human malignant melanoma xenograft: Effect of hypoxic cell radiosensitizers
148. In vitro and in vivo radiosensitivity of human tumour cells obtained from a pancreatic carcinoma xenograft
149. Radiobiological basis of oxygen as a modifying factor in radiation therapy
150. Effect of induced host anaemia on the viability and radiosensitivity of murine malignant cells in vivo
151. Human tumor xenografts in radiotherapeutic research
152. Human tumour xenografts: a critical appraisal
153. Radiation response of autochthonous mammary tumors in SHN mice
154. Experimental radiation therapy and apparent radioresistance of autochthonous tumors subcutaneously induced with 3-methylcolanthrene in mice
155. Radiation sensitivity and recovery patterns of spontaneous and isologously transplanted mouse tumors
156. Response of anoxic C3H mouse mammary carcinoma isotransplants (1–25 cu mm) to X irradiation
157. The response of viable tumor cords to a single dose of radiation
158. The effect of hypoxia on the generation time of mammalian cells
159. Cell cycle kinetics of aerated, hypoxic, and re-aerated cells in vitro using flow cytometric determination of cellular DNA and incorporated bromodeoxyuridine
160. Towards a further understanding of the growth-inhibiting action of oxygen deficiency
161. Deoxycytidylate shortage is a cause of G1 arrest of ascites tumor cells under oxygen deficiency
162. Inhibition of cell cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia
163. The kinetics of tumour cell proliferation and radiotherapy
164. The relationship between cell proliferation and the vascular system in a transplanted mouse tumor
165. Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor
166. Characteristics of a serially transplanted mouse mammary tumor and its tissue culture adapted derivative
167. Evidence for the recruitment of noncycling clonogenic tumor cells
168. The proliferative status and clonogenic capacity of tumour cells in a transplantable rhabdomyosarcoma of the rat before and after irradiation with 800 rad of X-rays
169. The proliferative state of clonogenic cells in the Lewis Lung tumor after treatment with cytotoxic drugs
170. Cell proliferation in EMT6 tumors treated with single dose of X-rays or hydroxyurea. I. Experimental results
171. Cell cycle distribution of chronically hypoxic cells and determination of the clonogenic potential of cells accumulated in G2+M phases after irradiation of a solid tumor in vivo
172. Evidence for repair capacity in mouse tumors relative to skin
173. A change in the oxygen effect throughout the cell-cycle of human cells of the line NH1K 3025 cultured in vitro
174. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
175. The sensitivity of micro-organisms to irradiation under controlled gas conditions
176. Effects of radiation on animal tumor models
177. The in vitro sensitivity of chronically hypoxic EMT6/SF cells to x-radiation and hypoxic cell radiosensitizers
178. The effect of oxygen on cellular survival and recovery after irradiation
179. The recovery of the survival curve shoulder after protracted hypoxia
180. Potentiation of radiation effects in hypoxic HeLa cells
181. An estimation of changes in proportions and absolute numbers of hypoxic cells after irradiation of transplanted C3H mouse mammary tumours
182. The effect of single and fractionated doses of X-rays in the effective proportion of hypoxic cells in C3H mouse mammary tumors
183. Reoxygenation as a function of tumor size and histopathological type
184. The oxygen effect and radiotherapy with fast neutrons
185. Repair of potentially lethal radiation damage in vitro and in vivo
186. Repair of potentially lethal radiation damage in acutely and chronically hypoxic tumor cells
187. Dependence of response of a C3H mammary carcinoma to fractionated irradiation on fraction number and intertreatment interval
188. The detection and measurement of hypoxic cells in solid tumors
189. The fraction of hypoxic clonogenic cells in tumor populations
190. Misonidazole and other hypoxia markers: Metabolism and applications
191. A marker for hypoxic cells in tumors with potential clinical applicability
192. Binding of misonidazole to V79 spheroids and fragments of Dunning rat prostatic and human colon carcinomas in vitro: diffusion of oxygen tumor and reactive metabolites
193. Changes in misonidazole binding with hypoxic fraction
194. The labeling of EMT-6 tumours in BALB/C mice with 14C misonidazole
195. Brominated misonidazole as a probe for hypoxic cells and as a radiosensitizer
196. Bromomisonidazole: Synthesis and characterization of a new radiosensitizer
197. Fluorescent nitroheterocycles for identifying hypoxic cells
198. Nitroakridin 2582: A fluorescent nitroacridine stain for identifying hypoxic cells
199. Oxygen and nitroreductase-dependent binding of AF-2 in spheroids and murine tumors
200. Comparison between the binding of [3H]misonidazole and AF-2 in Chinese hamster V79 spheroids
201. Regional variation in the oxygenation of mouse mammary tumours in vivo demonstrated by fluorescence of pyridine nucleotide
202. Role of NADPH-cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin-C
203. Hypoxia mediated binding of misonidazole to non-malignant tissue
204. In vitro hypoxic cytotoxicity of nitroimidazoles: Uptake and cell cycle phase selectivity
205. Preliminary observations of oxygen levels in microcirculation of tumors in C3H mice
206. Hypoxia in neoplastic tissue
207. Oxygenation of malignant tumors after localized microwave hyperthermia
208. Measurement of mammary blood flow in unanesthetized rats
209. The in vitro sensitivities to radiation and misonidazole of mouse bone marrow cells derived from different microenvironments
210. Human tumors as examined by in vitro 31P NMR in athymic mice
211. Correlations between 31P NMR spectroscopy and 15O perfusion measurements in the RIF-1 murine tumor in vivo
212. 31P nuclear magnetic resonance spectroscopic investigations of human neuroblastoma in situ
213. 31P NMR spectroscopy of in vivo tumors
214. Covalent binding of a fluorinated 2-nitroimidazole to EMT6 tumors in Balb/C mice: Detection by F-19 nuclear magnetic resonance at 2.35 T
215. ESR studies of O2 uptake by Chinese hamster ovary cells during the cell cycle
216. A low frequency imaging electron spin resonance spectrometer for non-invasive measurement of tumor oxygenation and other parameters characterizing tumor radiosensitivity
217. Cryophotometry as a method for analyzing intracapillary HbO2 saturation of organs under different O2 supply conditions
218. Tumor oxygenation under normoxic and hyperbaric conditions
219. Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia
220. Tumor size dependency in the radiation response of the Lewis lung carcinoma
221. Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour
222. The effect of tumor size and host anemia on tumor cell survival after irradiation
223. An appraisal of in vitro assays of excised tumours
224. The response of hypoxic B16 melanoma cells to in vivo treatment with chemotherapeutic agents
225. Influence of tumour size on radiosensitization by misonidazole
226. Oxygen effect factor and tumor volume in the C3H mouse mammary carcinoma
227. Tumor size: A factor influencing the isoeffect analysis of tumor response to combined modalities
228. Radiation dose fractionation and high pressure oxygen in radiotherapy of the DBA mouse mammary carcinoma
229. Effect of heat and ionizing radiation on normal and neoplastic tissue of the C3H mouse
230. Tests of two electron-affinic radiosensitizers in vivo using regrowth of an experimental carcinoma
231. Further investigations of the effects of the hypoxic-cell radiosensitizer, Ro-07-0582, on local control of a mouse tumour
232. The radiosensitivity of a murine fibrosarcoma as measured by three cell survival assays
233. Response of the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages
234. Comparison of the effects of neutron and/or photon irradiation on spontaneous squamous-cell carcinoma in mice
235. Reoxygenation between radiotherapy fractions in an experimental osteosarcoma
236. A survival curve for mammalian leukaemia cells irradiated in vivo (implications for treatment of mouse leukaemia by whole-body irradiation)
237. The effect of tissue oxygen tension on the radiosensitivity of leukaemia cells irradiated in situ in the livers of leukaemic mice
238. Combinations of radiation and misonidazole in a murine lung tumor model