Studies on the mechanism of action of probucol

The American Journal of Cardiology

Volumn 57, Issue 16, 1986, Pages

  Steinberg, Daniel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PHENOL DERIVATIVE; PROBUCOL; 4 BROMOPHENACYL BROMIDE; COLESTYRAMINE; LOW DENSITY LIPOPROTEIN;

ANIMAL; ARTICLE; DRUG EFFECT; HUMAN; KINETICS; MACROPHAGE; METABOLISM; MONOCYTE; MOUSE; OXIDATION REDUCTION REACTION; RABBIT; STIMULATION; ANIMAL MODEL; ATHEROGENESIS; DRUG EFFICACY; DRUG MECHANISM; METHODOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PERIPHERAL VASCULAR SYSTEM; PRIORITY JOURNAL; SHORT SURVEY;

ANIMAL; HUMAN; KINETICS; LIPOPROTEINS, LDL CHOLESTEROL; MACROPHAGES; MICE; MONOCYTES; OXIDATION-REDUCTION; PHENOLS; PROBUCOL; RABBITS; RECEPTORS, LDL; STIMULATION, CHEMICAL; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023057910     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/0002-9149(86)90430-3     Document Type: Article

References (29)

1. Mode of action of a new hypocholesterolemic drug (DH-581) in familial hypercholesterolemia
2. Effect of probucol on cholesterol synthesis, plasma lipoproteins and the activities of lipoprotein and hepatic lipase in the rat
3. Effects of clofibrate, cholestyramine, zanchol, probucol and AOMA feeding on hepatic and intestinal cholesterol metabolism and on biliary lipid secretion in the rat
4. Effects of probucol on low density lipoprotein removal and high density lipoprotein synthesis
5. Influence of probucol on cholesterol and lipoprotein metabolism in man
6. Effect of probucol on cholesterol metabolism in the rat
7. The effects of probucol on plasma lipoproteins in polygenic familial hypercholesterolemia
8. The hypolipidemic action of probucol: a study of its effects on high and low density lipoproteins
9. Treatment of homozygous familial hypercholesterolemia with probucol
10. Effects of probucol on homozygous cases of familial hypercholesterolemia
11. Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit). Incidence and development of atherosclerosis
12. A novel mechanism by which probucol lowers LDL levels demonstrated in the LDL receptor-deficient rabbit
13. Cholestyramineinduced changes in low density lipoprotein composition and metabolism: I. Studies in the guinea pig
14. The effect of diet on the transport of probucol in monkeys
15. Binding site on macrophages that mediates uptake and degradation of acetyiated low density lipoproteins, producing massive cholesterol depletion
16. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by the receptor for acetylated low density lipoprotein
17. Interaction of plasma lipoproteins with endothelial cells
18. Low density lipoprotein toxicity induced by free radical peroxidation of lipid
19. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation
20. Modification of low density lipoprotein by endothelial cells involves lipid. peroxidation and degradation of low density lipoprotein phospholipids
21. 2 activity in endothelial cell-induced modification of low density lipoprotein
22. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture
23. Macrophage oxidation of low density lipoprotein generates a modified form recognized by the macrophage receptor for acetyiated low density lipoprotein
24. Endothelial cell derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein
25. Probucol inhibits oxidative modification of low density lipoprotein
26. Lipid peroxide levels of serum lipoprotein fractions of diabetic patients
27. Studies on the role of peroxides in human pathology
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29. Turnover of in vivo modified low density lipoprotein in the rabbit