메뉴 건너뛰기




Volumn 50, Issue , 1986, Pages 31-42

Lung protection by a thiol-containing antioxidant: N-acetylcysteine

Author keywords

Free radicals; Glutathione; N acetylcysteine; Oxidants; Thiol homeostasis

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; MALEIC ACID DIETHYL ESTER; THIOL DERIVATIVE; TOBACCO SMOKE;

EID: 0023029952     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000195086     Document Type: Article
Times cited : (238)

References (19)
  • 1
    • 0019183068 scopus 로고
    • Multieenler Study Group: Long-term oral acetylcysteine in chronic bronchitis, a double-blind controlled study
    • Multieenler Study Group: Long-term oral acetylcysteine in chronic bronchitis, a double-blind controlled study. Eur. J. resp. Dis. 61: suppl. 111, pp. 93–108 (1980).
    • (1980) Eur. J. Resp. Dis. 61: Suppl , vol.111 , pp. 93-108
  • 2
    • 0020615142 scopus 로고
    • Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: Report of a trial organized by the Swedish Society for Pulmonary Diseases
    • Boman, G.; Bäcker, U.; Larsson, S.; Melander, B.; Wåhlander, L.: Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases. Eur. J. resp. Dis. 64: 405–415 (1983).
    • (1983) Eur. J. Resp. Dis , vol.64 , pp. 405-415
    • Boman, G.1    Bäcker Larsson, U.S.2    Melander, B.3    Wåhlander, L.4
  • 5
    • 0021680816 scopus 로고
    • Glutathione biosynthesis in the isoialed perfused rat lung: Utilization of extracellular glutathione
    • Berggren, M.; Dawson, J.; Moldeus, P.: Glutathione biosynthesis in the isoialed perfused rat lung: utilization of extracellular glutathione. FEBS Lett. 176: 189–192 (1984).
    • (1984) FEBS Lett , vol.176 , pp. 189-192
    • Berggren, M.1    Dawson, J.2    Moldeus, P.3
  • 6
    • 0011787534 scopus 로고
    • Use or isolated cells in the study of paracetamol metabolism and toxicity: Capacity of conjugative pathways and glutathione homeostasis
    • Davis, Tredger, Williams, Pitman Medical, London
    • Moldeus, P.: Use or isolated cells in the study of paracetamol metabolism and toxicity: capacity of conjugative pathways and glutathione homeostasis; in Davis, Tredger, Williams. Drug reactions in the Liver pp. 114–156 (Pitman Medical, London 1985).
    • (1985) Drug Reactions in the Liver , pp. 114-156
    • Moldeus, P.1
  • 7
    • 0018195287 scopus 로고
    • The glutathione status of cells
    • Kosower, N.S.; Kosower, E.M.: The glutathione status of cells. Int. Rev. Cytol. 54: 109–160 (1978).
    • (1978) Int. Rev. Cytol , vol.54 , pp. 109-160
    • Kosower, N.S.1    Kosower, E.M.2
  • 8
    • 0345198014 scopus 로고
    • The multiple roles of glutathione in drug metabolism
    • Orrenius, S.; Moldeus, P.: The multiple roles of glutathione in drug metabolism. Trends pharmac. Sci. 5: 432–435 (1984).
    • (1984) Trends Pharmac. Sci , vol.5 , pp. 432-435
    • Orrenius, S.1    Moldeus, P.2
  • 9
    • 0021705694 scopus 로고
    • Thiyl radicals, formation during peroxidase-cata-lyzed metabolism of acetaminophen in the presence of thiols
    • Ross, D.; Albano, E.; Nilsson, U.; Moldeus, P.: Thiyl radicals, formation during peroxidase-cata-lyzed metabolism of acetaminophen in the presence of thiols. Biochem. biophys. Res. Commun. 125: 109–115 (1984).
    • (1984) Biochem. Biophys. Res. Commun , vol.125 , pp. 109-115
    • Ross, D.1    Albano, E.2    Nilsson, U.3    Moldeus, P.4
  • 10
    • 0022388398 scopus 로고
    • The generation and fate of glutathione radicals in biological systems
    • Ross, D.; Norbeck, K.; Moldeus, P.: The generation and fate of glutathione radicals in biological systems. J. biol.Chem. 260: 15028–15032 (1985).
    • (1985) J. Biol.Chem , vol.260 , pp. 15028-15032
    • Ross, D.1    Norbeck, K.2    Moldeus, P.3
  • 11
    • 0020982223 scopus 로고
    • Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen
    • Werers, H.; Sies, H.: Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen. Eur. J. Biochem. 127: 29–36 (1983).
    • (1983) Eur. J. Biochem , vol.127 , pp. 29-36
    • Werers, H.1    Sies, H.2
  • 12
    • 0022360705 scopus 로고
    • The interaction of reduced glutathione with active oxygen species generated by xanthine oxidasc-catalyzed metabolism of xanthine
    • Ross, D.; Cotgreave, I.; Moldeus, P.: The interaction of reduced glutathione with active oxygen species generated by xanthine oxidasc-catalyzed metabolism of xanthine. Biochim. biophys. Acta 841: 278–282 (1975).
    • (1975) Biochim. Biophys. Acta , vol.841 , pp. 278-282
    • Ross, D.1    Cotgreave, I.2    Moldeus, P.3
  • 13
    • 0022200994 scopus 로고
    • N-Acetylcysteine protection against the toxicity of cigarette smoke and cigarette smoke condensates in various tissues and cells in vivo
    • Moldeus, P.; Berggren, M.; Grafstrom, R.: N-Acetylcysteine protection against the toxicity of cigarette smoke and cigarette smoke condensates in various tissues and cells in vivo. Eur. J. resp. Dis. 66: suppl. 139, pp. 123–129 (1985).
    • (1985) Eur. J. Resp. Dis. 66: Suppl , vol.139 , pp. 123-129
    • Moldeus, P.1    Berggren, M.2    Grafstrom, R.3
  • 14
    • 0019119443 scopus 로고
    • Pharmacokinetics of oral acetylcysteine; absorption, binding and metabolism in patients with respiratory disorders
    • Rodenstein, D.; De Coster, A.; Gazzaniga, A.: Pharmacokinetics of oral acetylcysteine; absorption, binding and metabolism in patients with respiratory disorders. Eur. J. resp. Dis. 61: suppl. 111, pp. 59–60 (1980).
    • (1980) Eur. J. Resp. Dis. 61: Suppl , vol.111 , pp. 59-60
    • Rodenstein, D.1    De Coster, A.2    Gazzaniga, A.3
  • 15
    • 84940634980 scopus 로고    scopus 로고
    • Simple methodologies for the determination of reduced and oxidized, low molecular weight and protein thiol components of biological systems using monobromobimane
    • in press
    • Cotgreave, I.A.; Moldéus, P.: Simple methodologies for the determination of reduced and oxidized, low molecular weight and protein thiol components of biological systems using monobromobimane. Biochem. biophys. Meth. (in press).
    • Biochem. Biophys. Meth
    • Cotgreave, I.A.1    Moldéus, P.2
  • 16
    • 84940634981 scopus 로고    scopus 로고
    • Methodologies for the analysis of reduced and oxidized N-acetylcysteine in biological systems using monobromobimane
    • (in press).
    • Cotgreave, I.A.; Moldeus, P.: Methodologies for the analysis of reduced and oxidized N-acetylcysteine in biological systems using monobromobimane. Biochem. Drug Dispos. (in press).
    • Biochem. Drug Dispos
    • Cotgreave, I.A.1    Moldeus, P.2
  • 18
    • 84940634983 scopus 로고    scopus 로고
    • : Gastrointestinal metabolism of N-acetylcysteine in the rat including a novel assay for sulfite in biological systems
    • in press
    • Cotgreave, I.A.; Berggren, M.; Jones, T.W.; Dawson, J.; Moldeus, P.: Gastrointestinal metabolism of N-acetylcysteine in the rat including a novel assay for sulfite in biological systems. Biochem. Drug Dispos. (in press).
    • Biochem. Drug Dispos
    • Cotgreave, I.A.1    Berggren, M.2    Jones, T.W.3    Dawson, J.4    Moldeus, P.5
  • 19
    • 0021905244 scopus 로고
    • Hepatic thiol and glutathione efflux under the influence of vasopressin, phenylephrine and adrenaline
    • Sies, H.; Graf, P.: Hepatic thiol and glutathione efflux under the influence of vasopressin, phenylephrine and adrenaline. Biochem. J. 226: 545–549 (1985).
    • (1985) Biochem. J , vol.226 , pp. 545-549
    • Sies, H.1    Graf, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.