The cytotoxic and mutagenic properties of cholesterol oxidation products

Food and Chemical Toxicology

Volumn 24, Issue 10-11, 1986, Pages 1103-1110

  Sevanian, A ^a   Peterson, A R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; EPOXIDE; FREE RADICAL; LIPID PEROXIDE;

7 OXOCHOLESTANOL; ANIMAL; ANIMAL CELL; CYTOTOXICITY; HEREDITY; LIPID OXIDATION; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CATTLE; CELL MEMBRANE; CHOLESTEROL; CYTOTOXINS; EPOXY COMPOUNDS; ETHERS, CYCLIC; FREE RADICALS; IN VITRO; LIPID PEROXIDES; LIPOSOMES; MUTAGENS; OXIDATION-REDUCTION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023025961     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0278-6915(86)90295-4     Document Type: Article

References (33)

1. 27 steroids by soybean lipoxygenase and rat liver microsomes
2. 7-oxygenated cholesterol and beta-sitosterol metabolites in cell-free preparations of liver
3. A colorimetric micro-determination of peroxide values utilizing aluminum chloride as the catalyst
4. Analysis and physiological significance of cholesterol epoxide in animal tissue
5. Etiologic related studies of ultraviolet light-mediated carcinogenesis
6. Interactions of 5 alpha 6 alpha cholesterol oxide with DNA and other nucleophiles
7. The mechanistic pleurality of cytochrome P-450 and its biological ramifications
8. Effects of adrenalectomy on hormone action on hepatic glucose metabolism
9. Role of calcium in cell death
10. Epoxide hydrolases in the catabolism of sterols and isoprenoids
11. Enzyme hydroxylation
12. Transformation of hamster embryo cells by cholesterol-alpha-epoxide and lithocholic acid
13. Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic and arene oxides
14. The oxidation of cholesterol in rat liver subcellular particles
15. Properties of liver microsomal cholesterol 5,6-oxide hydrolase
16. Oxidized derivatives of cholesterol and its interference with the calcium channel
17. Hepatic epoxide hydrase: structure-activity relationships for substrates and inhibitors
18. Effects of cholesterol oxidation products on membrane functions
19. Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells
20. Estimation of the potency of chemicals that produce genetic damage
21. Mutagens in nipple aspirates of breast fluids
22. Effects of vitamin E deficiency and nitrogen dioxide exposure on lung lipid peroxidation: use of lipid epoxides and malonaldehyde as measures of peroxidation
23. Catalytic properties and inhibition of hepatic cholesterol epoxide hydrolase
24. Cholesterol epoxide is a direct acting mutagen
25. Epoxides as products of lipid autoxidation in rat lungs
26. Lipid epoxide hydrase in rat lung preparations
27. Sterol metabolism
28. The mechanism of NADPH-dependent lipid peroxidation
29. Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase
30. Mechanisms of tumor promotion: potential role of intercellular communication
31. Biotransformation of cholesterol to cholestane-3β,5α,6β-triol via cholesterol epoxide in bovine adrenal cortex
32. Autoxidation of phosphatidylcholine liposomes