Developmental expression of genes for the stereoidogenic enzymes P450scc (20,22-desmolase), P450cl7 (17αhydroxylase/17,20-lyase), and P450c21 (21-hydroxylase) in the human fetusxsxs

Journal of Clinical Endocrinology and Metabolism

Volumn 63, Issue 5, 1986, Pages 1145-1150

  Voutilainen, Raimo ^a   Miller, Walter L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); MESSENGER RNA; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE;

ADRENAL GLAND; ENDOCRINE SYSTEM; FETUS; HUMAN; HUMAN CELL; MALE GENITAL SYSTEM; METHODOLOGY; ONTOGENY; PLACENTA; PREGNANCY; PRIORITY JOURNAL; STEROIDOGENESIS; TESTIS;

ALDEHYDE-LYASES; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DNA; EMBRYO AND FETAL DEVELOPMENT; FEMALE; FETUS; HUMAN; MALE; OVARY; OXIDOREDUCTASES; RNA, MESSENGER; STEROID 17-ALPHA-HYDROXYLASE; STEROID 21-HYDROXYLASE; STEROID HYDROXYLASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TESTIS;

EID: 0023025676     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-63-5-1145     Document Type: Article

References (38)

1. Simpson ER 1979 Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis. Mol Cell Endocrinol 13:213
2. Matteson KJ, Chung B, Urdea MS, Miller WL 1986 Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450scc oligodeoxyribonucleotide probes. Endocrinology 118:1296
3. Chung B, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL, Human cholesterol side-chain cleavage enzyme P450scc: cDNA cloning, assignment of the gene to chromosome 15 and expression in the placenta. Proc Natl Acad Sci USA, in press
4. Kimura T 1981 ACTH stimulation on cholesterol side chain activity of adrenocortical mitochondria. Mol Cell Biochem 36:105
5. Kramer RE, Gallant S, Brownie AC 1980 Actions of angiotensin II on aldosterone biosynthesis in the rat adrenal cortex: effects on cytochrome P-450 enzymes of the early and late pathway. J Biol Chem 255:3442
6. Voutilainen R, Tapanainen J, Chung B, Matteson KJ, Miller WL 1986 Hormonal regulation of P450scc (20,22 desmolase) and P450cl7 (17α-hydroxylase/ 17,20 lyase) in cultured human granulosa cells. J Clin Endocrinol Metab 63:202
7. Nakajin S, Shinoda M, Haniu M, Shively JE, Hall PF 1984 C21 steroid side chain cleavage enzyme from porcine adrenal micro-somes. Purification and characterization of the 17α-hydroxylase/ C17,20-lyase cytochrome P450. J Biol Chem 259:3971
8. Matteson KJ, Picado-Leonard J, Chung B, Mohandas TK, Miller WL 1986 Assignment of the gene for human adrenal P450c17 (17α-hydroxylase/17,20 lyase) to chromosome 10. J Clin Endocrinol Metab, 63:789, in press
9. Kominami S, Ochi H, Kobayashi Y, Takemori S 1980 Studies on the steroid hydroxylation system in adrenal cortex microsomes. J Biol Chem 255:3386
10. Chung B, Matteson KJ, Miller WL 1985 Cloning and characterization of the bovine gene for steroid 21-hydroxylase (P-450c21). DNA 4:211
11. Chung B, Matteson KJ, Miller WL 1986 Structure of a bovine gene for P450c21 (steroid 21-hydroxylase) defines a novel cytochrome P450 gene family. Proc Natl Acad Sci USA 83:4243
12. White PC, Chaplin DD, Weis JH, Dupont B, New MI, Seidman JG 1984 Two steroid 21-hydroxylase genes are located in the murine S region. Nature 312:465
13. Parker KL, Chaplin DD, Wong M, Seidman JG, Smith JA, Schimmer BP 1985 Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Yl adrenocortical tumor cells. Proc Natl Acad Sci USA 82:7860
14. Carrol MC, Campbell RD, Porter RR 1985 Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex in man. Proc Natl Acad Sci USA 82:521
15. Higashi Y, Yoshioka H, Yamane M, Gotoh O, Fujii-Kuriyama Y 1986 Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene. Proc Natl Acad Sci USA 83:2841
16. Streeter GL 1920 Weight, sitting height, head size, foot length and menstrual age of the human embryo. Contrib Embryol 11:143
17. Miller WL, Leisti S, Johnson LK 1982 Synthesis of growth hormone, prolactin and proopiomelanocortin by intact adult ovine pituitary tissue in vitro. Endocrinology 111:1358
18. Cathala G, Savouret J-F, Mendez B, West BL, Karin M, Martial JA, Baxter JD 1983 A method for isolation of intact, translationally active ribonucleic acid. DNA 2:329
19. Thomas PS 1980 Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci USA 77:5201
20. Gunning P, Ponte P, Okayama H, Engel J, Blau H, Kedes L 1983 Isolation and characterization of full-length cDNA clones for human α-, β-, and γ-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol 3:787
21. Seron-Ferre M, Lawrence CC, Siiteri PK, Jaffe RB 1978 Steroid production by definitive and fetal zones of the human fetal adrenal gland. J Clin Endocrinol Metab 47:603
22. Voutilainen R 1979 Steroidogenesis in tissue culture of fetal and adult human adrenals with special reference to cortisol/corticosterone ratio and aldosterone secretion. J Steroid Biochem 10:115
23. Voutilainen R, Kahri AI, Lahteenmaki P 1981 The effect of dehy-droepiandrosterone and its sulphate on human midterm placental secretion of hCG, progesterone, estrone and estradiol-17β in tissue culture. J Steroid Biochem 14:1153
24. Branchaud CL, Goodyer CG, Lipowski LS 1983 Progesterone and estrogen production by placental monolayer cultures: effect of dehydroepiandrosterone and luteinizing hormone-releasing hormone. J Clin Endocrinol Metab 56:761
25. Hellig H, Gattereau D, Lefebvre Y, Bolte E 1970 Steroid production from plasma cholesterol. I. Conversion of plasma cholesterol to placental progesterone in humans. J Clin Endocrinol Metab 30:624
26. Simpson ER, MacDonald PC 1981 Endocrine physiology of the placenta. Annu Rev Physiol 43:163
27. Tapanainen J, Kellokumpu-Lehtinen P, Pelliniemi L, Huhtaniemi I 1981 Age-related changes in endogenous steroids of human fetal testis during early and midpregnancy. J Clin Endocrinol Metab 52:98
28. Faiman C, Winter JSD, Reyes FI 1981 Endocrinology of the fetal testis. In: Burger H, de Kretser D (eds) The Testis. Comprehensive Endocrinology. Raven Press, New York, p 81
29. Ahluwalia B, Williams J, Verma P 1974 in vitro testosterone biosynthesis in the human fetal testis. II. Stimulation by cyclic AMP and human chorionic gonadotropin (hCG). Endocrinology 95:1411
30. Huhtaniemi IT, Korenbrot CC, Jaffe RB 1977 hCG binding and stimulation of testosterone biosynthesis in the human fetal testis. J Clin Endocrinol Metab 44:963
31. Clements JA, Reyes FI, Winter JSD, Faiman C 1976 Studies on human development. III. Fetal pituitary and serum and amniotic fluid concentrations of LH, CG and FSH. J Clin Endocrinol Metab 42:9
32. Molsberry RL, Carr BR, Mendelson CR, Simpson ER 1982 Human chorionic gonadotropin binding to human fetal testes as a function of gestational age. J Clin Endocrinol Metab 55:791
33. Payne AH, Jaffe RB 1974 Androgen formation from pregnenolone sulfate by the human fetal ovary. J Clin Endocrinol Metab 39:300
34. Reyes FI, Boroditsky RS, Winter JDS, Faiman C 1974 Studies on human sexual development. II. Fetal and maternal serum gonadotropin and sex steroid concentrations. J Clin Endocrinol Metab 38:612
35. George FW, Wilson JD 1978 Conversion of androgen to estrogen by the human fetal ovary. J Clin Endocrinol Metab 47:550
36. Casey ML, Winkel CA, MacDonald PG 1983 Conversion of progesterone to deoxycorticosterone in the human fetus: steroid 21-hydroxylase activity in fetal tissues. J Steroid Biochem 18:449
37. Winkel CA, Casey ML, Worley RL, Madden JD, MacDonald PC 1983 Extraadrenal steroid 21-hydroxylase activity in a woman with congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency. J Clin Endocrinol Metab 56:104
38. Tukey RH, Okino S, Barnes H, Griffin KJ, Johnson EF 1985 Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P450 1. J Biol Chem 260:13347