Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate

Journal of Inherited Metabolic Disease

Volumn 9, Issue 3, 1986, Pages 244-252

  Kuroda, Y ^a   Ito, M ^a   Toshima, K ^a   Takeda, E ^a   Naito, E ^a   Hwang, T J ^a   Hashimoto, T ^a   Miyao, M ^a   Masuda, M ^b   Yamashita, K ^b   Adachi, T ^b   Suzuki, Y ^c   Nishiyama, K ^c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKUSHIMA PREFECTURAL CENTRAL HOSPITAL   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DICHLOROACETIC ACID; DRUG;

ADOLESCENT; CASE REPORT; CENTRAL NERVOUS SYSTEM; DRUG THERAPY; ENCEPHALOMYOPATHY; HUMAN; INBORN ERROR OF METABOLISM; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; MUSCLE; ORAL DRUG ADMINISTRATION; PYRUVATE BLOOD LEVEL; THERAPY;

ACETIC ACIDS; ACIDOSIS; ADOLESCENT; BRAIN; DICHLOROACETATE; HUMANS; INFANT, NEWBORN; KIDNEY; LACTATES; LACTIC ACID; LIVER; MALE; MUSCLES; NEUROMUSCULAR DISEASES;

EID: 0022993853     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/BF01799655     Document Type: Article

References (23)

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7. Dichloroacetate tissue concentrations and its relationship to hypolactatemia and pyruvate dehydrogenase activation
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17. Long term use of low dichloroacetate in a child with congenital lactic acidosis
18. Lactic acidosis neurological deterioration and compromised cellular pyruvate oxidation due to a defect in the reoxidation of cytoplasmically generated NADH
19. Treatment of lactic acidosis with dichloroacetate
20. Toxicity of chronic dichloroacetate
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23. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids