Azasteroids: Structure-Activity Relationships for Inhibition of 5a-Reductase and of Androgen Receptor Binding

Journal of Medicinal Chemistry

Volumn 29, Issue 11, 1986, Pages 2298-2315

  Rasmusson, Gary H ^a   Reynolds, Glenn F ^a   Steinberg, Nathan G ^a   Walton, Edward ^a   Patel, Gool F ^a   Liang, Tehming ^b   Cascieri, Margaret A ^b   Cheung, Anne H ^b   Brooks, Jerry R ^b   Berman, Charles ^b  

^a Department of Synthetic Chemical Research ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AZA 5ALPHA ANDROSTAN 3 ONE DERIVATIVE; 4 AZASTEROID DERIVATIVE; 5ALPHA ANDROSTAN 3 ONE DERIVATIVE; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTANOLONE H 3; STEROID; STEROID 5ALPHA REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ANALYSIS; DRUG BINDING; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENDOCRINE SYSTEM; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE GENITAL SYSTEM; PHARMACOKINETICS; PRIORITY JOURNAL; PROSTATE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZASTEROIDS; HUMANS; MALE; PROSTATE; RATS; RECEPTORS, ANDROGEN; STEROIDS, HETEROCYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0022971248     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00161a028     Document Type: Article

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