Cytochrome p‐450: Target for itraconazole

Drug Development Research

Volumn 8, Issue 1-4, 1986, Pages 287-298

  Vanden Bossche, Hugo ^a   Bellens, Dany ^a   Cools, Willy ^a   Gorrens, Jos ^a   Marichal, Patrick ^a   Verhoeven, Hugo ^a   Willemsens, Gustaaf ^a   De Coster, Roland ^a   Beerens, Dominiek ^a   Haelterman, Christian ^a   Coene, Marie‐Claire ^a   Lauwers, William ^a   le Jeune, Ludo ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

androgens; estrogens; glucocorticoids; ketoconazole; mineralocorticoids; sterols

Indexed keywords

ANDROGEN; CYTOCHROME P450; ESTROGEN; GLUCOCORTICOID; ITRACONAZOLE; KETOCONAZOLE; LANOSTEROL; MINERALOCORTICOID;

ADVERSE DRUG REACTION; BLOOD AND HEMOPOIETIC SYSTEM; CANDIDA ALBICANS; DRUG SENSITIVITY; ENDOCRINE SYSTEM; FUNGUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHATIC SYSTEM; LYMPHOCYTE; MALE GENITAL SYSTEM; MICROSOME; NONHUMAN; PRIORITY JOURNAL; STEROID METABOLISM; TESTIS; TOPICAL DRUG ADMINISTRATION;

EID: 0022921986     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.430080133     Document Type: Article

References (20)

1. Receptor mediated gonadotropin action in gonadal tissues: Relationship between blood cholestrol levels and gonadotropin stimulated steroidogenesis in isolated rat Leydig and luteal cells
2. Endocrinological effects of single daily ketoconazole administration in male beagle dogs
3. Biosynthesis of two new steroids in the human foetal liver, 1β‐ and 2β‐hydroxytestosterone
4. The carbon monoxide‐binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
5. Assessment of eleven adrenal steroids from a single serum sample by combination automatic high‐performance liquid chromatography and radioimmunoassay (HPLC‐RIA)
6. Rates of strol synthesis and uptake in the major organs of the rat in vivo
7. Biochemical targets for antifungal azole derivatives: Hypothesis on the mode of action
8. Effects of the antimycotics, miconazole and ketoconazole, on cytochrome P‐450 in yeast microsomes and rat liver microsomes
9. The molecular basis for the antifungal activities of N‐substituted azole derivatives. Focus on R 51 211
10. Effects of etomidate on steroid biosynthesis in sub‐cellular fractions of bovine adrenals
11. Yeast and plant cytochrome P‐450 enzymes: Targets for azole derivatives
12. The cytochrome P‐450 dependent C17,20‐lyase in subcellular fractions of the rat testis: Differences in sensitivity to ketoconazole and itraconazole
13. Ketoconazole, an inhibitor of the cytochrome P‐450 dependent testosterone biosynthesis
14. Pharmacology and clinical uses of ketoconazole
15. OKT3: Monoclonal anti‐human T‐lymphocyte antibody with potent mitogenic properties
16. 4‐3‐oxosteroid‐α‐oxido‐reductase activity in cultured interstitial cells derived from immature rat testis
17. Effects of ketoconazole on the testicular and adrenal cholesterol side‐chain cleavage
18. Oxygen activation by cytochrome P‐450
19. Interaction of azole fungicides with yeast cytochrome P‐450 which catalyzes lanosterol 14α‐demethylation