Effect of Chlormadinone Acetate, a Synthetic Progesterone, on Restoring Impaired Load Compensation in Chronic Obstructive Pulmonary Disease

The Tohoku Journal of Experimental Medicine

Volumn 149, Issue 2, 1986, Pages 119-132

  Kimura, Hiroshi ^a   Tatsumi, Kouichiro ^a   Kuriyama, Takayuki ^a   Sugita, Takashi ^a   Watanabe, Shohei ^a   Nishibayasht, Yoshitake ^b   Honda, Yoshiyuki ^b  

^a Institute of Pulmonary Cancer Research   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

C02 response; load compensation; occlusion pressure; progesterone

Indexed keywords

CARBON DIOXIDE; CHLORMADINONE; CHLORMADINONE ACETATE; PROGESTERONE;

ASTHMA; BREATHING MECHANICS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; DRUG EFFICACY; DRUG THERAPY; HUMAN; MOUTH OCCLUSION PRESSURE; ORAL DRUG ADMINISTRATION; RESPIRATORY DRIVE; RESPIRATORY SYSTEM; THERAPY;

ADULT; AGED; BLOOD GAS ANALYSIS; CARBON DIOXIDE; CHLORMADINONE ACETATE; FEMALE; HUMANS; LUNG DISEASES, OBSTRUCTIVE; MALE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS;

EID: 0022921695     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.149.119     Document Type: Article

References (34)

1. 2 rebreathing in sitting and supine subjects. Proc. int. Union Physiol. Sci., 14, 296.
2. 2) Altose, M.D., McCauley, W.C., Kelsen, S.G. & Cherniack, N.S. (1977) Effects of hypercapnia and inspiratory flow-resistive loading on respiratory activity in chronic airway obstruction. J. clin. Invest., 59, 500–507.
3. 3) Altose, M.D., Kelsen, S.G. & Cherniack, N.S. (1979) Respiratory responses to changes in airflow resistance in conscious man. Resp. Physiol., 36, 249–260.
4. 4) Block, A.J., Wynne, J.W. & Boysen, P.G. (1980) Sleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women. Amer. J. Med., 69, 75–79.
5. 5) Burki, N.K. & Baker, R.W. (1984) Ventilatory regulation in eucapnic morbid obesity. Amer. Rev. resp. Dis., 129, 538–543.
6. 6) Burrows, B., Niden, A.H., Fletcher, C.M. & Jones, N.L. (1964) Clinical types of chronic obstructive lung disease in London and in Chicago : A study of one hundred patients. Amer. Rev. resp. Dis. 90, 14–27.
7. 7) Cullen, J.H., Brum, V.C. & Reidt, W.U. (1959) The respiratory effects of progesterone in severe pulmonary emphysema. Amer. J. Med., 27, 551–557.
8. 8) DeMarco, F.J., Wynne, J.W., Block, A.J., Boysen, P.G. & Taasan, V.C. (1981) Oxygen desaturation during sleep as a determinant of the “Blue and Bloated” syndrome. Chest, 79, 621–625.
9. 9) Dolly, F.R. & Block, A.J. (1983) Medroxyprogesterone acetate and COPD : Effect on breathing and oxygenation in sleeping and awake patients. Chest, 84, 394–398.
10. 2. J. appl. Physiol., 14, 721–726.
11. 11) Fishman, A.P., Samet, P. & Cournand, A. (1955) Ventilatory drive in chronic pulmonary emphysema. Amer. J. Med., 19, 533–548.
12. 12) Gelb, A.F., Klein, E., Schiffman, P., Lugliani, R. & Aronstam, P. (1977) Ventilatory response and drive in acute and chronic obstructive pulmonary disease. Amer. Rev. resp. Dis., 116, 9–16.
13. 13) Gottfried, S.B., Altose, M.D., Kelsen, S.G. & Cherniack, N.S. (1981) Perception of changes in airflow resistance in obstructive pulmonary disorders. Amer. Rev. resp. Dis., 124, 566–570.
14. 14) Hinshaw, H.C. & Murray, J.F. (1980) Diseases of the Chest. 4th ed., Saunders Company, Philadelphia, pp. 560–590.
15. 15) Imura, H. & Nakai, Y. (1981) “Endorphins” in pituitary and other tissues. Ann. Rev. Physiol., 43, 265–278.
16. 16) Kato, J., Onouchi, T. & Okinaga, S. (1978) Hypothalamic and hypophysial progesterone receptors : Estrogen-priming effect, differential localization, 5α-dihydroprogesterone binding, and nuclear receptors. J. Steroid Biochem., 9, 419–427.
17. 17) Kelsen, S.G., Fleegler, B. & Altose, M.D. (1979) The respiratory neuromuscular response to hypoxia, hypercapnia, and obstruction to airflow in asthma. Amer. Rev. resp. Dis., 120, 517–527.
18. 18) Kelsen, S.G., Rao, L., Cherniack, N.S., Gothe, B. & Altose, M.D. (1979) Respiratory adjustments to ventilatory loading in chronic obstructive pulmonary disease : Muscular and neural factors. Amer. Rev. resp. Dis., 119, Suppl. 1, 159–164.
19. 2 drives by chlormadinone acetate, a synthetic progesterone. J. appl. Physiol., 56, 1627–1632.
20. 20) Lourenço, R.V. & Miranda, J.M. (1968) Drive and performance of the ventilatory apparatus in chronic obstructive lung disease. New Engl. J. Med., 279, 53–59.
21. 21) Matthews, A.W. (1977) The relationship between central carbon dioxide sensitivity and clinical features in patients with chronic airway obstruction. Quart. J. Med., 182, 179–195.
22. 22) Mountain, R., Zwillich, C. & Weil, J. (1978) Hypoventilation in obstructive lung disease: The role of familial factors. New Engl. J. Med., 298, 521–525.
23. 23) Read, D.J.C. (1967) A clinical method for assessing the ventilatory response to carbon dioxide. Aust. Ann. Med., 16, 20–32.
24. 24) Rebuck, A.S. & Juniper, E.F. (1975) Effect of resistive loading on ventilatory response to hypoxia. J. appl. Physiol., 38, 965–968.
25. 25) Santiago, T.V., Remolina, C., Scoles, V., III. & Edelman, N.H. (1981) Endorphins and the control of breathing. Ability of naloxone to restore flow-resistive load compensation in chronic obstructive pulmonary disease. New Engl. J. Med., 304, 1190–1195.
26. 26) Schaefer, K.E., Hastings, B.J., Carey, C.R. & Nichols, G., Jr. (1963) Respiratory acclimatization to carbon dioxide. J. appl. Physiol., 18, 1071–1078.
27. 27) Skatrud, J.B., Dempsey, J.A., Bhansali, P. & Irvin, C. (1980) Determinants of chronic carbon dioxide retention and its correction in humans. J. clin. Invest., 65, 813–821.
28. 2 retention during sleep in patients with chronic obstructive pulmonary disease. Amer. Rev. resp. Dis., 124, 260–268.
29. 29) Sorli, J., Grassino, A., Lorange, G. & Milic-Emili, J. (1978) Control of breathing in patients with chronic obstructive lung disease. Clin. Sci. Mol. Med., 54, 295–304.
30. 30) Stubbing, D.G., Killian, K.J. & Campbell, E.J.M. (1983) Weber’s law and resistive load detection. Amer. Rev. resp. Dis., 127, 5–7.
31. 31) Tirlapur, V.G. & Mir, M.A. (1982) Nocturnal hypoxemia and associated electrocardiographic changes in patients with chronic obstructive airways disease. New Engl. J. Med., 306, 125–130.
32. 32) Tyler, J.M. (1960) The effect of progesterone on the respiration of patients with emphysema and hypercapnia. J. clin. Invest., 39, 34–41.
33. 33) Vermeulen, A. (1976) The hormonal activity of the postmenopausal ovary. J. clin. Endocr., 42, 247–253.
34. 34) Yoshida, A., Hayashi, F., Sasaki, K., Masuda, Y. & Honda, Y. (1981) Analysis of pressure profile in the occluded airway obtained at the beginning of inspiration in steady state hypercapnia. Amer. Rev. resp. Dis., 124, 252–256.