Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam

Neuropharmacology

Volumn 25, Issue 5, 1986, Pages 541-544

  Corda, M G ^a   Biggio, G ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

anxiety; bicuculline; diazepam; GABA benzodiazepine receptor complex; pentylenetetrazol; picrotoxin; proconflict effect; Ro 15 1788

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE RECEPTOR; BICUCULLINE; DIAZEPAM; FLUMAZENIL; PENTETRAZOLE; PICROTOXIN;

ANIMAL EXPERIMENT; ANXIETY; BEHAVIOR; CENTRAL NERVOUS SYSTEM; CONFLICT; DOSE RESPONSE; DRUG COMPARISON; DRUG EFFICACY; DRUG INTERACTION; DRUG RESPONSE; INTRAPERITONEAL DRUG ADMINISTRATION; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; BENZODIAZEPINONES; BICUCULLINE; CONFLICT (PSYCHOLOGY); DIAZEPAM; FLUMAZENIL; MALE; PENTYLENETETRAZOLE; PICROTOXIN; RATS; RATS, INBRED STRAINS; RECEPTORS, GABA-A;

EID: 0022904979     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(86)90181-4     Document Type: Article

References (25)

1. The action of stress, β-carbolines, diazepam and Rol 15-1788 on GABA receptors in the rat brain
2. Rapid changes in GABA binding induced by stress in different areas of the rat brain
3. Stress and β-carbolines decrease the density of low affinity GABA binding sites: an effect reversed by diazepam
4. The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines
5. Interaction of convulsive ligands with benzodiazepine receptors
6. Potentiation by intraventricular muscimol of the anticonflict effect of benzodiazepines
7. Beta-carbolines and benzodiazepines: Interaction between negative and positive modulators of GABA-induced conductance changes on cultured chick neurons
8. 3H-GABA binding in membrane preparation of rat cerebral cortex
9. β-Carbolines enhance shockinduced suppression of drinking in rats
10. Involvement of GABA in the facilitation of punishment suppressed behaviour induced by β-carbolines in rat
11. Molecular mechanism in the receptor action of benzodiazepines
12. Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat
13. Severe anxiety induced by FG 7142, a β-carboline ligand for benzodiazepine receptors
14. Proconflict action of Ro 15-1788 a purported inert antagonist of benzodiazepine recognition site
15. max of γ-aminobutyric acid—A recognition site in brain regions of mice receiving diazepam
16. Anxiogenic actions of picrotoxin and pentylenetetrazol Reversal by chlordiazepoxide
17. General pharmacology and neuropharmacology of benzodiazepine derivatives
18. Selective antagonists of benzodiazepines
19. Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated postsynaptic inhibition of cultured mammalian neurons
20. GABA-benzodiazepine-barbiturate receptor interactions
21. Proconflict effect of benzodiazepine receptor inverse agonists and other inhibitors of GABA function
22. Differential pharmacological effects of BZ receptor inverse agonists
23. Ethyl-β-carboline-3-carboxylate antagonizes the action of GABA and benzodiazepines in the hippocampus
24. Diazepam enhancement of low affinity GABA binding to rat brain membranes
25. Further evidence for GABAergic mechanisms in the action of benzodiazepines