The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non-lysosomal proteolytic system

FEBS Letters

Volumn 209, Issue 1, 1986, Pages 139-144

  Nicotera, Pierluigi ^a   Hartzell, Pia ^a   Davis, Gregory ^a   Orrenius, Sten ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cytosolic Ca2+ Blebbing Proteolysis Hepatotoxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIMYCIN; CALCIUM; CYSTAMINE;

ANIMAL CELL; CELL MEMBRANE; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMAL; CALCIMYCIN; CALCIUM; CELL MEMBRANE; CELL SURVIVAL; CYSTAMINE; IN VITRO; KINETICS; LIVER; MALE; MICROSCOPY, ELECTRON, SCANNING; PEPTIDE HYDROLASES; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0022901787     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(86)81099-7     Document Type: Article

References (19)

1. Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.