Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative

Biochemical Pharmacology

Volumn 35, Issue 24, 1986, Pages 4493-4497

  Muth, Eric A ^a   Haskins, John T ^a   Moyer, John A ^a   Husbands, George E M ^a   Nielsen, Susan T ^a   Sigg, Ernest B ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); ANTIDEPRESSANT AGENT; IMIPRAMINE; IMIPRAMINE H 3; NEUROTRANSMITTER RECEPTOR; NEW DRUG; RADIOISOTOPE; UNCLASSIFIED DRUG; VENLAFAXINE;

ANIMAL CELL; ARTICLE; BIOLOGICAL MODEL; CENTRAL NERVOUS SYSTEM; DRUG ADMINISTRATION; DRUG BINDING; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GUINEA PIG; ILEUM; METHODOLOGY; MONOAMINE UPTAKE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SMALL INTESTINE;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOLOGICAL ASSAY; BRAIN; CYCLOHEXANOLS; DESIPRAMINE; DOPAMINE; GUINEA PIGS; IMIPRAMINE; MONOAMINE OXIDASE INHIBITORS; MUSCLE CONTRACTION; NOREPINEPHRINE; RATS; SEROTONIN; SYNAPTOSOMES;

EID: 0022879288     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(86)90769-0     Document Type: Article

References (22)

1. Muscarinic Cholinergic Binding in Rat Brain
2. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction