Immunotoxins

Cell

Volumn 47, Issue 5, 1986, Pages 641-648

  Pastan, Ira ^a   Willingham, Mark C ^a   FitzGerald, David J P ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; DIPHTHERIA TOXIN; GELONIN; N METHYLTRYPTOPHAN; PSEUDOMONAS EXOTOXIN; RICIN; SAPORIN;

CANCER CHEMOTHERAPY; DRUG RECEPTOR BINDING; DRUG TOXICITY; ENDOCYTOSIS; INTOXICATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; THERAPY;

ANIMAL; ANTIBODIES, MONOCLONAL; BIOLOGICAL AVAILABILITY; BONE MARROW TRANSPLANTATION; ENDOCYTOSIS; HUMAN; IMMUNOTOXINS; LYMPHOCYTE DEPLETION; NEOPLASMS; NEOPLASMS, EXPERIMENTAL;

EID: 0022869035     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(86)90506-4     Document Type: Review

References (72)

1. Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Å resolution
2. Guinea pig line 10 hepatocarcinoma model: characterization of monoclonal antibody and in vivo effect of unconjugated antibody and antibody conjugated to diphtheria toxin A chain
3. Evaluation of monoclonal antibodies for the development of breast cancer immunotoxins
4. Antibody-Pseudomonas exotoxin A conjugates cytotoxic to human breast cancer cells in vitro
5. New heterobifunctional protein cross-linking reagent that forms an acid-labile link
6. Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells
7. Study of the plasma clearance antibody-richin-A-chain immunotoxins: evidence for specific recognition sites on the A chain that mediate rapid clearance of the immunotoxin
8. Monoclonal antibody and an antibody-toxin conjugate to a cell surface proteoglycan of melanoma cells suppress in vivo tumor growth
9. Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97
10. Kinetics of cytotoxicity induced by immunotoxins
11. Epidermal growth factor regulates the expression of its own receptor
12. Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain activity in cell entry
13. Preparation of antibody-toxin conjugates
14. Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line
15. Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis
16. Monitoring the therapy of human tumor xenografts in nude mice by the use of lactate dehydrogenase
17. Transferrin receptor as a target for antibody-drug conjugates
18. The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement
19. Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease
20. Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptormediated endocytosis
21. Enhancement of toxicity of antitransferrin receptor anti-body-pseudomonas exotoxin conjugates by adenovirus
22. Pseudomonas exotoxin-anti-TAC: cell-specific immunotoxin active against cells expressing the human T-cell growth factor receptor
23. Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer
24. Anti-tumor activity of two immunotoxins directed against human ovarian cancer cells in nude mice
25. Construction of immunotoxins using Pseudomonas exotoxin A
26. Transferrin receptors in human tissue: their distribution and possible clinical relevance
27. Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis
28. Antibody-directed cytotoxic agents: Use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells
29. Kinetics of protein synthesis inactivation by diphtheria toxin in toxin-resistant L-cells
30. Virus entry into animal cells
31. Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells
32. Selective antitumor effect on L10 hepatocarcinoma cells of a potent immunoconjugate composed of the A chain of abrin and a monoclonal antibody to a hepatoma-associated antigen
33. Entry of diphtheria toxin into cells: Possible existence of cellular factor(s) for entry of diphtheria toxin into cells was studied in somatic cell hybrids and hybrid toxin
34. Nucleotide sequence of cloned cDNA coding for preproricin
35. Purified immunotoxins that are reactive with human lymphoid cells
36. Expression of enzymatic activity by exotoxin A from Pseudomonas aeruginosa
37. Importance of the antigen-binding valency and the nature of the cross-linking bond in ricin A-chain conjugates with antibody
38. Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies
39. Response of cultured cells to the exotoxins of Pseudomonas aeruginosa and corynebacterium diphtheria: differential toxicity
40. Bacterial toxins: Cellular mechanisms of action
41. Toxic lectins and related proteins
42. Entry of polypeptide toxins into mammalian cells
43. Diphtheria toxin
44. Receptor-mediated endocytosis: Coated pits, receptosomes and the Golgi
45. The pathway of endocytosis
46. Anti-transferrin receptor antibody linked to pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines
47. Characterization of immunotoxins active against ovarian cancer cell lines
48. Comparison of the selective cytoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies
49. Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 antigen disulfide linked to two ribosomal inhibitors: Pokeweed antiviral protein or Ricin A chain
50. Inhibition of human acute lymphoblastic leukemia cells by immunotoxins: Potentiation by chloroquine
51. Immunological and biological stability of immunotoxins in vivo as studies by the clearance of disulphide-linked pokeweed antiviral protein-antibody conjugates from blood
52. Diphtheria toxin entry into cells is facilitated by low pH
53. Rapid entry of nicked diphtheria toxin into cells at low pH
54. Pathway of Adenovirus Entry into Cells
55. Potential clinical utility of monoclonal antibodies in the management of human carcinomas
56. cis-aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate
57. Modification of the carbohydrate in ricin with metaperiodate and cyanoborohydride mixtures: effect on binding, uptake and toxicity to parenchymal and non-parenchymal cells of rat liver
58. Selective killing of malignant cells in a leukaemic rat bone marrow using an antibody-ricin conjugate
59. An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria Officinalis: Potent antitumor effects in vitro and in vivo
60. Anti-transferrin receptor monoclonal antibody and toxin-antibody conjugates affect growth of human tumour cells
61. 2-macroglobulin
62. Anti-T-cell reagents for human bone marrow transplantation: ricin linked to three monoclonal antibodies
63. Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells
64. Cytotoxicity of a cell-reactive immunotoxin-containing ricin A chain is potentiated by an antiimmunotoxin containing ricin B chain
65. r 67,000 protein immunotoxins on human tumors in a nude mouse model
66. Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor
67. The receptosome: An intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts
68. The transit of epidermal growth factor through coated pits of the Golgi system
69. Fate of an antibody-ricin A chain conjugate administered to normal rats
70. One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell
71. Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin
72. Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids