Treatment of Chronic Non-A, Non-B Hepatitis with Recombinant Human Alpha Interferon

New England Journal of Medicine

Volumn 315, Issue 25, 1986, Pages 1575-1578

  Hoofnagle, Jay H ^a   Mullen, Kevin D ^a   Jones, D Brian ^a   Rustgi, Vinod ^a   di Bisceglie, Adrian ^a   Peters, Marion ^a   Waggoner, Jeanne G ^a   Park, Yoon ^a   Jones, E Anthony ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AMINOTRANSFERASE; RECOMBINANT ALPHA2 INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT INTERFERON;

ADVERSE DRUG REACTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; DISEASE ACTIVITY; DRUG DOSE; DRUG EFFICACY; DRUG THERAPY; FATIGUE; HEADACHE; HEPATITIS NON A NON B; HISTOLOGY; HUMAN; IRRITABILITY; LIVER; MYALGIA; PRIORITY JOURNAL; SERUM; SUBCUTANEOUS DRUG ADMINISTRATION; THERAPY; TREATMENT;

ADULT; CHRONIC DISEASE; FEMALE; HEPATITIS C; HEPATITIS, VIRAL, HUMAN; HUMANS; INTERFERON TYPE I; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; TRANSAMINASES;

EID: 0022868893     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198612183152503     Document Type: Article

References (17)

1. Alter HJ, Hoofnagle JH. Non-A, non-B: observations on the first decade. In: Vyas GN, Dienstag JL, Hoofnagle JH, eds. Viral hepatitis and liver disease. Orlando, Fia.: Grune & Stratton, 1984:345–54.
2. Aach RD, Szmuness W, Mosley JW, et al. Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis in recipients: the transfusion-transmitted viruses study. N Engl J Med 1981; 304: 989–94.
3. Alter HJ, Purcell RH, Holland PV, Ailing DW, Koziol DE. Donor transaminase and recipient hepatitis; impact on blood transfusion services. JAMA 1981; 246: 630–4.
4. Seeff LB, Wright EC, Zimmerman HJ, et al. Post-transfusion hepatitis 1973–1975: a Veterans Administration cooperative study. In: Vyas GN, Cohen SN, Schmid R, eds. Viral hepatitis: a contemporary assessment of etiology, epidemiology, pathogeriesis, and prevention. Philadelphia: Franklin Institute Press, 1978:371–81.
5. Alter MJ, Gerety RJ, Smallwood LA, et al. Sporadic non-A, non-B hepatitis: frequency and epidemiology in an urban U.S. population. J Infect Dis 1982; 145: 886–93.
6. Berman M, Alter HJ, Ishak KG, Purcell RH, Jones EA. The chronic sequelae of non-A, non-B hepatitis. Ann Intern Med 1979; 91: 1–6.
7. Koretz RL, Stone O, Gitnick GL. The long-term course of non-A, non-B post-transfusion hepatitis. Gastroenterology 1980; 79: 893–8.
8. Realdi G, Alberti A, Rugge M, et al. Long-term follow-up of acute and chronic non-A, non-B post-transfusion hepatitis: evidence of progression to liver cirrhosis. Gut 1982; 23: 270–5.
9. Scullard GH, Pollard RB, Smith JL, et al. Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. J Infect Dis 1981; 143: 772–83.
10. Dusheiko G, Dibisceglie A, Bowyer S, et al. Recombinant leukocyte interferon treatment of chronic hepatitis B. Hepatology 1985; 5: 556–60.
11. Peters M, Davis GL, Dooley JS, Hoofnagle JH. The interferon system in acute and chronic hepatitis. In: Popper H, Schaffner F, eds. Progress in liver disease. Vol. 8. Orlando, Fia.: Grune & Stratton, 1986:453–67.
12. Sherlock S, Thomas HC. Treatment of chronic hepatitis due to hepatitis B virus. Lancet 1985; 2: 1343–6.
13. Hoofnagle JH, Smedile A, Mullen KD, et al. Treatment of chronic delta hepatitis with recombinant human alpha interferon. Gastroenterology 1985; 88: 1665. abstract.
14. Hoofnagle JH, Feinstone SM. Serologic tests for non-A, non-B hepatitis: controversy. Liver 1981; 1: 177–82.
15. Dienstag JL. Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features. Gastroenterology 1983; 85: 439–62.
16. Dienstag Non-A, non-B hepatitis. II. Experimental transmission, putative virus agents and markers, and prevention. Gastroenterology 1983; 85: 743–68.
17. Vallbracht A, Flehmig B. Elimination of a persistent hepatitis A infection in cell cultures by interferon. In: Kirchner H, Schellekens H, eds. The biology of the interferon system 1984. New York: Elsevier, 1985:339–45.