Chemically induced aneuploidy in mammalian cells in culture

Mutation Research/Reviews in Genetic Toxicology

Volumn 167, Issue 1-2, 1986, Pages 89-105

  Galloway, Sheila M ^a   Ivett, James L ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Litton Bionetics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 IMIDAZOLIDINETHIONE; ASBESTOS; BENZ[A]ANTHRACENE; BENZO[A]PYRENE; CARBARIL; CHEMICAL MUTAGEN; CYPROHEPTADINE; DEMECOLCINE; DIAZEPAM; DICHROMATE POTASSIUM; DIETHYLSTILBESTROL; DIMETHYLBENZ[A]ANTHRACENE; DISTAMYCIN A; ESTRADIOL; ETHIDIUM BROMIDE; ETHOSUXIMIDE; GRISEOFULVIN; HALOTHANE; MERCURIC CHLORIDE; METRONIDAZOLE; MICONAZOLE; MITOMYCIN C; NITROUS OXIDE; OLIVETOL; PHENYTOIN; PHORBOL 13 ACETATE 12 MYRISTATE; PRIMIDONE; RHODAMINE B; TESTOSTERONE; VANADATE SODIUM; VINBLASTINE;

ANEUPLOIDY; CELL CULTURE; CHEMICAL MUTAGENESIS; CHROMOSOME; DRUG EFFICACY; HEREDITY; IN VITRO STUDY; MAMMAL; MAMMAL CELL; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANEUPLOIDY; ANIMAL; BIOTRANSFORMATION; CELL LINE; CELLS, CULTURED; CROSSES, GENETIC; EVALUATION STUDIES; HUMAN; HYDROGEN-ION CONCENTRATION; KINETICS; METAPHASE; MUTAGENICITY TESTS; MUTAGENS; SUPPORT, U.S. GOV'T, NON-P.H.S.; TEMPERATURE;

EID: 0022657402     PISSN: 01651110     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1110(86)90011-4     Document Type: Review

References (110)

1. Effects of parafluorophenylalanine on chromosome structure in human lymphoid cells and Chinese hamster V79-E cells
2. Quantitation of spindle-inhibiting effects of metal compounds by chromosome length measurements
3. Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation
4. Sample size considerations
5. Studies on the clastogenic effects of biologic stains and dyes
6. Cytogenetic toxicity of gentian violet and crystal violet on mammalian cells in vitro
7. The incidence of spontaneous and radiation-induced chromosome damage in a trisomic variant of a diploid mammalian cell line
8. Recombinant DNA approaches to studying control of cell proliferation: An overview
9. Mutagenicity and carcinogenicity of N-methyl-N′-nitro-N-nitrosoguanidine, I. Induction of chromosome aberrations and mitotic anomalies in Chinese hamster ovary cells
10. Polycyclic hydrocarbon-produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures
11. Patient with 13 chromosome deletion: Evidence that the retinoblastoma gene is a recessive cancer gene
12. Microtubule crystals A new biophysical phenomenon induced by Vinca alkaloids
13. Cytogenetic effects of lead and cadmium compounds on ascitic tumour cells in the mouse
14. Chromosomes and anticonvulsant drugs
15. erythro-9-[3-(2-Hydroxynonyl)]adenine is an inhibitor of sperm motility that blocks dynein ATPase and protein carboxymethylase activities
16. Nitrous oxide: Effects on the mitotic apparatus and chromosome movement in HeLa cells
17. Cytoplasmic microtubules in normal and transformed cells in culture: Analysis by tubulin antibody immunofluorescence
18. Microtubule-organizing centres during the cell cycle of 3T3 cells
19. Non-random chromosome loss in PHA-stimulated lymphocytes from normal individuals
20. Isolation of Chinese hamster ovary cell mutants requiring the continuous presence of taxol for cell division
21. CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin
22. Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration of alpha-tubulin
23. Inhibition of spindle elongation in permeabilized mitotic cells by erythro-9-(3-(2-hydroxynonyl))adenine
24. Chromosome movement in lysed mitotic cells is inhibited by vanadate
25. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
26. The effect of non-phorbol promoters as compared with phorbol myristate acetate on sister chromatid exchange induction in cultured Chinese hamster cells
27. A quantitative analysis of colcemid-induced chromosomal nondisjunction in Chinese hamster cells in vitro
28. The in vitro isolation and characterization of monosomic sublines derived from a colcemid-treated Chinese hamster cell population
29. Measurement of levels of aneuploidy in mammalian cells using a modified hypotonic treatment
30. Anormal cell division in cultured human fibroblasts after exposure to diethylstilboestrol
31. 1 chromosome assay
32. Cytoplasmic microtubule assembly-disassembly from endogenous tubulin in a Brij-lysed cell model
33. Homozygosity of chromosome 13 in retinoblastoma
34. Tumor promoter 12-O-tetradecanoylphorbol-13-acetate enhances sister chromatid exchanges and numerical and structural chromosome aberrations in primary mouse epidermal cell cultures
35. Tumour promoter phorbol-12-myristate-12-acetate induces chromosomal damage via indirect action
36. Tumor promoter phorbol 12-myristate-13-acetate induces a clastogenic factor in human lymphocytes
37. Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone
38. The nucleolus, virus infection, and trisomy in man
39. A mechanism of X chromosome aneuploidy in ageing women
40. Aneuploidy and ageing: Chromosome studies on a random sample of the population using G-banding
41. False positive in vitro chromosome aberration tests with non-mutagens at high concentrations and osmolalities
42. Chromosome aberrations in cultured human leukocytes after treatment with fungicide ‘Benlate’
43. Mutants of Chinese hamster ovary cells affected in two different microtubule-associated proteins
44. Persistence of nucleoli in short term and long term cell cultures and in direct bone marrow preparations in mammalian materials
45. Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis
46. The effects of cyproheptadine on the chromosomes of human lymphocytes in vitro
47. Taxol: A new probe for studying the structure and function of microtubules
48. Aneuploidy induction by mitotic arrestants
49. Cytogenetic assays for mitotic poisons: The diploid Chinese hamster cell system
50. Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens
51. Nondisjunction of chromosomes in a synchronized cell population initiated by reversal of colcemid inhibition
52. Morphological, growth, and chromosomal changes in bovine pancreatic duct epithelial cells exposed to N-methyl-N′-nitro-N-nitrosoguanidine
53. The effect of Sevin on the chromosomal apparatus of cells in vitro
54. Micronucleus test on 21 compounds
55. Induction of chromosomal nondisjunction in normal and transformed cells of the Djungarian and Chinese hamsters in vitro
56. The mutagenicity of nitroaromatic drugs
57. Griseofulvin A potential agent of chromosomal segregation in cultured cells
58. Mutagenicity assays with griseofulvin
59. The effects of rhodamine B on the chromosomes of Muntiacus muntjac
60. Mutants of Chinese hamster ovary (CHO) cells with altered colcemid-binding affinity
61. Aneuploid effect of oestradiol on cultured human synovial cells
62. Effects of potassium dichromate on mitosis of cultured mammalian cells
63. Addition of colchicine-tubulin complex to microtubule ends; the mechanism of substoichiometric colchicine poisoning
64. Centrosomes and mitotic poles
65. Effects of ethidium bromide on mitosis and chromosomes: A possible material basis for chromosome stickiness
66. Effects of nucleic acid specific dyes on centrioles of mammalian cells
67. Errors of chromosome segregation induced by Olivetol, a compound with the structure of C-ring common to cannabinoids: Formation of bridges and multipolar divisions
68. 1 cells
69. Cytotoxic effects of griseofulvin on human normal cells in vitro
70. Mutagenic activity of 20 coded compounds in chromosome aberrations/sister chromatid exchanges assay using Chinese hamster ovary (CHO) cells
71. A carbamate herbicide causes microtubule and microfilament disruption and nuclear fragmentation in fibroblasts
72. Spindle disturbances in mammalian cells, II. Induction of viable aneuploid/polyploid cells and multiple chromatid exchanges after treatment of V79 Chinese hamster cells with carbaryl
73. Multipolar mitoses in tissue culture cells, under normal conditions and after induction with 2-mercaptoethanol
74. Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture
75. Flow cytometric measurement of cellular DNA content dispersion induced by mutagenic treatment
76. Mechanisms of spontaneous and induced heteroploidization and polyploidization
77. Differential staining of chromosomes and spindle and its use as an assay for determining the effect of diethylstilboestrol on cultured mammalian cells
78. Tubulin nucleation and assembly in mitotic cells: Evidence for nucleic acids in kinetochores and centrosomes
79. Mutagenicity of polycyclic hydrocarbons, III. Monitoring genetic hazards of benz[a]anthracene
80. Preliminary evaluation of the cytogenetic activity and potential mutagenic hazard of 22 pesticides
81. Enhancement of N-methyl-N′-nitro-N-nitrosoguanidine transformation of Syrian hamster cells by phorbol diester is independent of sister chromatid exchanges and chromosome aberrations
82. Mammalian in vivo and in vitro cytogenetic assays: A report of the U.S. E.P.A.'s Gene-Tox Program
83. Mitotic non-disjunction of sister chromatids and anomalous mitosis induced by low temperatures in HeLa cells
84. The effect of in vitro distamycin A exposure on metaphase chromosome structure
85. Inhibition by griseofulvin of microtubule assembly in vitro
86. Human oncogene locations and chromosome aberrations
87. Interaction of methylmercury with microtubules in cultured cells and in vitro
88. Mutagenic activity of 41 compounds in the in vivo micronucleus assay
89. A chromosomal hypothesis of oncogenesis
90. Cytogenetic effects of 60 chemicals on cultured human and Chinese hamster cells
91. The cytogenetic effect of an X-ray contrast medium on Chinese hamster cell cultures
92. Chromosomal aberrations of Don lung cells of Chinese hamster after exposure to vinblastine in vitro
93. Computer automation of metaphase finding, sister chromatid exchange and chromosome damage analysis
94. Chromosome mutations and pH disturbances
95. Mutagenicity screening on pesticides and modification products: A basis of carcinogenicity evaluation
96. Teratogenic and cytogenetic effects of some plant-derived anti-tumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice
97. Synergism between halothane and nitrous oxide in the production of nuclear abnormalities in the dividing fibroblast
98. Double Y as an indicator in a test of mitotic nondisjunction in cultured human lymphocytes
99. Chromosomal distribution in interspectific in vitro hybrid cells
100. Mutagenicity testing on ethylenethiourea
101. Activity of coded compounds in the micronucleus test
102. Aneuploidy induction and cell transformation by diethylstilbestrol: A possible chromosomal mechanism in carcinogenesis
103. Colcemid-induced neoplastic transformation and aneuploidy in Syrian hamster embryo cells
104. Correlation of cytotoxicity and mitotic spindle dissolution by vinblastine in mammalian cells
105. Increased DNA content as an early marker of transformation in carcinogen-exposed rat tracheal cell cultures
106. Mercury-induced segregational errors of chromosomes in human lymphocytes and in Indian muntjac cells
107. Sequence of centromere separation another mechanism for the origin of nondisjunction
108. Specific visualization of tubulin-containing structures in tissue culture cells by immunofluorescence
109. Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor nocodazole
110. Studies on the cytogenetic activity of some common fungicides in higher plants