A Controlled Trial of Methylprednisolone in the Emergency Treatment of Acute Asthma

New England Journal of Medicine

Volumn 314, Issue 3, 1986, Pages 150-152

  Littenberg, Benjamin ^a   Gluck, Eric H ^a  

^a HARTFORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMINOPHYLLINE; METHYLPREDNISOLONE; ORCIPRENALINE; OXYGEN; PLACEBO; PREDNISONE; TERBUTALINE;

ASTHMA; ASTHMATIC STATE; BRONCHOSPASM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG THERAPY; EMERGENCY; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY SYSTEM; THERAPY;

EID: 0022648556     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198601163140304     Document Type: Article

References (15)

1. Fanta CH, Rossing TH, McFadden ER Jr. Glucocorticoids in acute asthma: a critical controlled trial. Am J Med 1983; 74: 845–51.
2. Pierson WE, Bierman CW, Kelley VC A double-blind trial of corticosteroid therapy in status asthmaticus. Pediatrics 1974; 54: 282–8.
3. McFadden ER Jr, Kiser R, deGroot WJ, Holmes B, Kiker R, Viser G. A controlled study of the effects of single doses of hydrocortisone on the resolution of acute attacks of asthma. Am J Med 1976; 60: 52–9.
4. Rubinfeld AR, Pain MCF. Perception of asthma. Lancet 1976; 1: 882–4.
5. Morris JF. Spirometry in the evaluation of pulmonary function. West J Med 1976; 125: 110–8.
6. Ramsdell JW, Berry CC, Clausen JL. The immediate effects of cortisol on pulmonary function in normals and asthmatics. J Allergy Clin Immunol 1983; 72: 69–74.
7. Kalsner S. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ Res 1969; 24: 383–95.
8. Loren ML, Chai H, Leung P, Rohr C, Brenner AM. Corticosteroids in the treatment of acute exacerbations of asthma. Ann Allergy 1980; 45: 67–71.
9. Ellul-Micallef R, Fenech FF. Intravenous prednisolone in chronic bronchial asthma. Thorax 1975; 30: 312–5.
10. Klaustermeyer WB, Hale FC. The physiologic effect of an intravenous glucocorticoid in bronchial asthma. Ann Allergy 1976; 37: 80–6.
11. Fauci AS, Dale DC. The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. J Clin Invest 1974; 53: 240–6.
12. Dale DC, Fauci AS, Guerry DIV, Wolff SM. Comparison of agents producing a neutrophilic leukocytosis in man: hydrocortisone, prednisone, endotoxin, and etiocholanolone. J Clin Invest 1975; 56: 808–13.
13. Parker DW, Huber MG, Baumann ML. Alterations in cyclic AMP metabolism in human bronchial asthma. III. Leukocyte and lymphocyte responses to steroids. J Clin Invest 1973; 52: 1342–8.
14. Tukey JW. Some thoughts on clinical trials, especially problems of multiplicity. Science 1977; 198: 679–84.
15. National Center for Health Statistics. Utilization of short-stay hospitals. Vital and Health Statistics Series 13, No. 78. Hyattsville, Md.: Public Health Service, 1984. (DHHS publication no. (PHS)84–1739).