Delayed DNA maturation, a possible cause of the elevated sister-chromatid exchange in bloom's syndrome

Carcinogenesis

Volumn 7, Issue 1, 1986, Pages 53-57

  Ockey, C H ^a   Saffhill, R ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE;

BLOOM SYNDROME; CONGENITAL DISORDER; ETIOLOGY; HUMAN; HUMAN CELL; LYMPHATIC SYSTEM; SISTER CHROMATID EXCHANGE;

BLOOM SYNDROME; CELL CYCLE; CELL LINE; DNA; DNA REPLICATION; FIBROBLASTS; HUMAN; KINETICS; SISTER CHROMATID EXCHANGE; SUPPORT, NON-U.S. GOV'T; TEMPLATES, GENETIC;

EID: 0022644068     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/7.1.53     Document Type: Article

References (25)

1. Chaganti, R.S.K., Schonberg, S. and German, J. (1974), A many fold increast in sister-chromatid exchanges in Bloom’s syndrome lymphocytes, Proc. Natl. Acad. Sci. USA. 71, 4508-4512.
2. Hand, R. and German, J. (1975), A retarded rate of DNA chain growth it Bloom’s syndrome, Proc. Natl. Acad. Sci. USA, 72, 758-762.
3. Hand, R. and German, J. (1977), Bloom's syndrome: DNA replication ir cultured fibroblasts and lymphocytes, Hum. Genet., 38, 297-306.
4. Kapp, L.N. (1982), DNA fork displacement rates in Bloom’s syndrome fibroblasts, Biochim. Biophys. Acta, 696, 226-227.
5. Giannelli, F., Benson, P.E., Pawsey, S.A. and Polani, P.E. (1977), Ultraviolei light sensitivity and delayed DNA-chain maturation in Bloom’s syndrome fibro blasts, Nature, 265, 466-469.
6. Thompson, L.H., Rubin, J., Cleaver, J.E., Whitmore, G.F. and Brookman, K (1980), A screening method for isolating DNA repair-deficient mutants ol CHO cells, Somat. Cell Genet., 6, 391-405.
7. Dillehay, L.E., Thompson, L.H., Minkler, J.L. and Carrano, A.V. (1983), The relationship between sister-chromatid exchanges and perturbations in DNA replication in mutant EM9 and normal CHO cells, Mutat. Res., 109, 283-296.
8. Ray, J.H. and German, J. (1984), Bloom’s syndrome and EM9 cells in BrdU- containing medium exhibit similarly elevated frequencies of sister-chromatid exchanges but dissimilar amounts of cell proliferation and chromosome disruption, Chromosoma, 90, 383-388.
9. Shiraishi, Y., Yoshida, T.H. and Sandberg, A.V. (1983), Analyses of bromo- deoxyuridine associated sister-chromatid exchanges (SCEs) in Bloom’s syndrome based on cell fusion: single and twin SCEs in endoreduplication, Proc. Natl. Acad. Sci. USA, 80, 4369-1373.
10. Ockey, C.H. (1979), Quantitative replicon analysis of DNA synthesis in cancer prone conditions and the defects in Bloom’s syndrome, J. Cell Sci., 40, 125-144.
11. Suzuki, H. and Yoshida, T.H. (1983), Frequency of sister-chromatid exchanges depending on the amount of 5-bromodeoxyuridine incorporated into parental DNA, Mutat. Res., Ill, 277-282.
12. O’Neill, J.P., Heartlein, M.W. and Preston, R.H. (1983), Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA, Mutat. Res., 109, 259-270.
13. Shiraishi, Y., Yoshida, T.H. and Sandberg, A.A. (1982), Analysis of single and twin sister-chromatid exchanges in endoreduplicated normal and Bloom’s syndrome B-lymphoid cells, Chromosoma, 87, 1-8.
14. Shiraishi, Y. and Yoshida, T.H. (1983), Analysis by the three-way differentiation of Bloom’s syndrome sister chromatid exchanges in bromodeoxyuridine- substituted chromosomes, Proc. Jap. Acad. Ser. B, 59, 227-230.
15. Shiraishi, Y. and Sandberg, A.A. (1980), Sister chromatid exchange in human chromosomes, including observations in neoplasia, Cancer Genet. Cytogenet., 1, 363-380.
16. Creissen, D. and Shall, S. (1982), Regulation of DNA repair ligase activity by poly(ADP-ribose), Nature, 296, 271-272.
17. Schwartz, J.L., Morgan, W.F., Kapp, L.N. and Wolff, S. (1983), Effect of 3- aminobenzamide on DNA synthesis and cell cycle progression in Chinese hamster ovary cells, Exp. Cell Res., 143, 377-382.
18. Natarajan, A.T., Cuskas, I. and Van Zeeland, A.A. (1981), Contribution of incorporated 5-bromodeoxyuridine in DNA to the frequencies of sister chromatid exchanges induced by inhibitors of poly(ADP-ribose)-polymerase, Mutat. Res., 84, 125-132.
19. Makino, R. and Munakata, N. (1979), Excision of uracil from bromodeoxy- uridine substituted and UV-irradiated DNA in cultured mouse lymphoma cells, Int. J. Radiat. Biol., 36, 349-357.
20. Saffhill, R. and Ockey, C.H. (1985), The behaviour of the BrdU substituted template can explain SCE induction by both BrdU and MMS as a consequence of strand breaks resulting from excision repair, Chromosoma, in press.
21. Shiraishi, Y., Tonaka, Y., Kato, M., Miwa, M. and Sugimura, T. (1983), Effect of poly-(ADP-ribose) polymerase inhibition on the frequency of sister- chromatid exchanges in Bloom’s syndrome cells, Mutat. Res., 122, 223-228.
22. Perry, P. and Wolff, S. (1974), New Giemsa method for the differential staining of sister chromatids, Nature, 251, 156-158.
23. Ockey, C.H., Saffhill, R. and Booth, J.A. (1984), The effect of cell proliferation, bromodeoxyuridine concentration, and deoxynucleoside triphosphate pools on sister chromatid exchange induced, in Tice.R.R. and Hollaender.A. (eds.), Basic Life Sciences, Sister Chromatid Exchanges, Vol. 29A, Plenum Press, NY, pp. 267-279.
24. 6-methyldeoxyguanosine in DNA of cells alkylated in vitro and in vivo, Carcinogenesis, 4, 1605-1609.
25. Painter, R.B. (1977), Inhibition of initiation of HeLa cell replicons by methyl sulphonate, Mutat. Res., 42, 299-304.