Crystal Structure of the Dihydropyridine Ca2+ Antagonist Felodipine. Dihydropyridine Binding Prerequisites Assessed from Crystallographic Data

Journal of Medicinal Chemistry

Volumn 29, Issue 2, 1986, Pages 305-307

  Fossheim, Rune ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

FELODIPINE;

CRYSTALLOGRAPHY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; PHARMACOKINETICS; PRELIMINARY COMMUNICATION; PRIORITY JOURNAL; THEORETICAL STUDY;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; FELODIPINE; HYDROGEN BONDING; MOLECULAR CONFORMATION; NIFEDIPINE; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS; X-RAY DIFFRACTION;

EID: 0022643980     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00152a023     Document Type: Article

References (15)

1. Bostrom, S.; Ljung, B.; Mardh, S.; Forsen, S.; Thulin, E. Nature (London) 1981, 292, 777.
2. Fleckenstein, A. Ann. Rev. Pharmacol. Toxicol. 1977, 17, 149.
3. Reuter, H. Nature (London) 1983, 301, 569.
4. Janis, R. A.; Triggle, D. J. J. Med. Chem. 1983, 26, 775.
5. Triggle, A. M.; Shefter, E.; Triggle, D. J. J. Med. Chem. 1980, 23, 1442.
6. Fossheim, R.; Svarteng, K.; Mostad, A.; Romming, C.; Shefter, E.; Triggle, D. J. J. Med. Chem. 1982, 25, 126.
7. Fossheim, R. Acta Chem. Scand., in press.
8. Germain, G.; Main, P.; Woolfson, M. M. Acta Crystallogr., Sect. A 1971, 27A, 368.
9. Groth, P. Acta Chem. Scand. 1973, 27, 1837.
10. Berntsson, P.; Carter, R. E. Acta Pharm. Suec. 1981, 18, 221.
11. Tacke, R.; Bentlage, A.; Sheldrick, W. S.; Ernst, L.; Towart, R.; Stoepel, K. Z. Naturforsh. B 1982, 37B, 443.
12. Hempel, A.; Gupta, M. P. Acta Crystallogr., Sect. B 1978, B34, 3815.
13. Murray-Rust, P.; Glusker, J. P. J. Am. Chem. Soc. 1984, 106, 1018.
14. Bolger, G. T.; Gengo, P.; Klockowski, R.; Luchowski, E.; Siegel, H.; Janis, R. A.; Triggle, A. M.; Triggle, D. J. J. Pharmacol. Exp. Ther. 1983, 225, 291.
15. Troug, A. G. Presentation at the Federation of American Societies for Experimental Biology, 67th Annual Meeting, Chicago, 1983.