Ethylene oxide dose and dose‐rate effects in the mouse dominant‐lethal test

Environmental Mutagenesis

Volumn 8, Issue 1, 1986, Pages 1-7

  Generoso, W M ^a   Cain, K T ^a   Hughes, L A ^a   Sega, G A ^a   Braden, P W ^a   Gosslee, D G ^a   Shelby, M D ^b  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

dominant lethal mutations; dose rate; dose response; ethylene oxide; mice

Indexed keywords

ETHYLENE OXIDE;

ANIMAL EXPERIMENT; DOMINANT LETHAL TEST; DOSE RESPONSE; DRUG DOSE; DRUG RESPONSE; ETIOLOGY; HEREDITY; MALE GENITAL SYSTEM; MOUSE; MUTAGENICITY; NONHUMAN;

AIR POLLUTANTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE OXIDE; FEMALE; GENES, DOMINANT; GENES, LETHAL; MALE; MICE; MUTAGENICITY TESTS; MUTAGENS; PREGNANCY;

ANIMALIA;

EID: 0022643163     PISSN: 01922521     EISSN: 1930238X     Source Type: Journal    
DOI: 10.1002/em.2860080102     Document Type: Article

References (8)

1. Evaluation of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide
2. The mutagenic potential of ethylene oxide using the dominantlethal assay in rats
3. Heritable translocation and dominant‐lethal mutation induction with ethylene oxide in mice
4. Increased dominant‐lethal effects due to prolonged exposure of mice to inhaled ethylene oxide
5. Specific‐locus mutation rates in the mouse following inhalation of ethylene oxide, and application of the results to estimation of human genetic risk
6. Alkylation pattern in developing mouse sperm, sperm DNA and protamine after inhalation of ethylene oxide