Characterization of acquired epipodophyllotoxin resistance in a chinese hamster ovary cell line: Loss of drug-stimulated dna cleavage activity

Cancer Research

Volumn 46, Issue , 1986, Pages 1934-1938

  Glisson, Bonnie ^a   Gupta, Radhey ^b   Ross, Warren ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; EPIPODOPHYLLOTOXIN; ETOPOSIDE; RADIOISOTOPE;

CELL LINE; CHEMICAL MUTAGENESIS; CHO CELL; DNA DAMAGE; DRUG RESISTANCE; ETOPOSIDE H 3; FEMALE GENITAL SYSTEM; HEREDITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

AMINOACRIDINES; AMSACRINE; ANIMAL; CELL LINE; CRICETULUS; DNA; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE; ETOPOSIDE; FEMALE; HAMSTERS; OVARY; PODOPHYLLOTOXIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022638520     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Glisson, B.S., Smallwood, S.E., and Ross, W.E. Characterization of VP-16-induced DNA damage in isolated nuclei from L1210 cells. Biochim. Biophys. Acta, 783: 74-79, 1984.
2. Ross, W., Rowe, T., Glisson, B., Yalowich, J., and Liu, L. Role of topoisom-erase 11 in mediating epipodophyllotoxin-induced DNA cleavage. Cancer Res., 44: 5857-5860,1984.
3. Tewey, K.M., Chen, G.L., Nelson, E.M., and Liu, L.F. lntercalative antitumor drugs interfere with the breakage-reunion of mammalian DNA topoisomerase II. J. Biol. Chem., 259: 9182-9187, 1984.
4. Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., and Liu, L.F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisom-erase II. Science (Wash. DC), 226: 466-468,1984.
5. Nelson, E. M., Tewey, K. M., and Liu, L.F. Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by m-AMSA. Proc. Natl. Acad. Sci. USA, 81:1361-1365, 1984.
6. Yang, L., Rowe, T.C., Nelson, E.M., and Liu, L.F. In vivo mapping of DNa topoisomerase II specific cleavage sites on SV40 chromatin. Cell, 41: 127–132, 1985.
7. Wozniak, A. J., and Ross, W.E. DNA damage as a basis for 4’β-D-glucopyranoside) (etoposide) cytotoxicity. Cancer Res., 43: 120-124,1983.
8. DiNardo, S., Voelkel, K., and Sternglanz R. DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc. Natl. Acad. Sci. USA, 81:2616-2620, 1984.
9. Earnshaw, W. C., Halligan, B., Cooke, C. A., Heck, M.S., and Liu, L.F. Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol., 100: 1706–1715, 1985.
10. Liu, L. F., Rowe, T. C., Yang, L., Tewey, K.M., and Chen, G.L. Cleavage of DNA by mammalian DNA topoisomerase II. J. Biol. Chem., 258:15365-15370, 1983.
11. Chen, G. L., Yang, L., Rowe, T.C., Halligan, B.D., Tewey, K.M., and Liu, L.F. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem., 259:13560-13566, 1984.
12. Gupta, R. S. Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP-16-213. Cancer Res., 43: 1568–1574, 1983.
13. Norwood, T. H., Zeigler, C. J., and Martin, G.M. Dimethyl sulfoxide enhances polyethylene glycol-mediated somatic cell fusion. Somatic Cell Genet., 2:263-270, 1976.
14. Kohn, K.W., Erickson, L.C., Ewig, R.A.G., and Freidman, C.A. Fractionation of DNA from mammalian cells by alkaline elution. Biochemistry, 74:4629-4637, 1976.
15. Zwelling, L. A., Michaels, S., Erickson, L. C., Ungerleider, R.S., Nichols, M., and Kohn, K.W. Protein-associated deoxyribonucleic acid strand breaks in LI 210 cells treated with the deoxyribonucleic acid intercalating agents 4’-(9-acridinyl-amino)methanesulfon-m-anisidide and Adriamycin. Biochemistry, 20:6553-6563, 1981.
16. Yalowich, J.C., and Ross, W.E. Verapamil-induced augmentation of eto-poside accumulation in L1210 cells in vitro. Cancer Res., 45: 1651–1656, 1985.
17. Englund, P. T. The replication of kinetoplast DNA networks in Crithidia fasciculata. Cell, 14:157-168, 1978.
18. Clewell, D. B. Nature of Col E plasmid replication in Escherichia coli in the presence of chloramphenicol. J. Bacteriol., 10:667-676, 1972.
19. Duguet, M., Lavenot, C., Harper, F., Mirambeau, G., and De Recondo, A. DNA topoisomerases from rat liver: physiological variations. Nucleic Acids Res., 11: 1059–1075, 1983.
20. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72:248-254, 1976.
21. Glisson, B., Gupta, R., Hodges, P., and Ross, W. Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target. Cancer Res., 46:0000-0000, 1986.
22. Wozniak, A. J., Glisson, B. S., Hande, K. R., and Ross, W.E. Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents. Cancer Res., 44:626-632, 1984.
23. Rowe, T., Kupfer, G., and Ross, W. Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage. Biochem. Pharmacol., 34: 2483–2487, 1985.
24. Long, B. H., Musial, S. T., and Brattain, M.G. Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP-16-213 and VM-26: a quantitative structure-activity relationship. Biochemistry, 23:1183-1188,1984.