Studies of Platelet Activating Factor (PAF) Antagonists from Microbial Products. II. Pharmacological Studies of FR-49175 in Animal Models

Chemical and Pharmaceutical Bulletin

Volumn 34, Issue 1, 1986, Pages 345-348

  Okamoto, Masanori ^a   Yoshida, Keizo ^a   Uchida, Itsuo ^a   Kohsaka, Masanobu ^a   Aoki, Hatsuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

bronchoconstriction; FR 49175; PAF antagonist; PAF induced; PAF induced hypotension; PAF induced vascular permeability increase; platelet activating factor (PAF); systemic anaphylaxis

Indexed keywords

2,3,5A,6 TETRAHYDRO 6 HYDROXY 3 HYDROXYMETHYL 2 METHYL 3,10A BIS(METHYLTHIO)PYRAZINO[1,2 A]INDOLE 1,4 DIONE; ANTIGEN; THROMBOCYTE ACTIVATING FACTOR; TIARAMIDE;

2,3,5A,6 TETRAHYDRO 6 HYDROXY 3 HYDROXYMETHYL 2 METHYL 3,10A DIMETHYLTHIOPYRAZINO[1,2 A]INDOLE 1,4 DIONE; ANIMAL EXPERIMENT; BIOLOGICAL MODEL; BLOOD PRESSURE; BLOOD VESSEL PERMEABILITY; BRONCHOSPASM; CARDIOVASCULAR SYSTEM; DRUG ANTAGONISM; DRUG SCREENING; GUINEA PIG; INTRADERMAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PERIPHERAL VASCULAR SYSTEM; RAT; RESPIRATORY SYSTEM;

ANAPHYLAXIS; ANIMALS; BLOOD PRESSURE; BRONCHI; CAPILLARY PERMEABILITY; GLIOTOXIN; GUINEA PIGS; MALE; MICE; MYCOTOXINS; PENICILLIUM; PLATELET ACTIVATING FACTOR; RATS; RATS, INBRED STRAINS;

EID: 0022635072     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.34.345     Document Type: Article

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