메뉴 건너뛰기




Volumn 314, Issue 12, 1986, Pages 729-735

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYCLOSPORIN A; FOLINATE CALCIUM; METHOTREXATE;

EID: 0022624255     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198603203141201     Document Type: Article
Times cited : (1210)

References (43)
  • 1
    • 0018719188 scopus 로고
    • Marrow transplantation for acute nonlymphoblastic leukemia in first remission
    • Thomas ED, Buckner CD, Clift RA, et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med 1979; 301: 597–9.
    • (1979) N Engl J Med , vol.301 , pp. 597-599
    • Thomas, E.D.1    Buckner, C.D.2    Clift, R.A.3
  • 2
    • 0020698578 scopus 로고
    • Bone marrow ablation followed by allogeneic marrow grafting during first complete remission of acute nonlymphocytic leukemia
    • Forman SJ, Spruce WE, Farbstein MJ, et al. Bone marrow ablation followed by allogeneic marrow grafting during first complete remission of acute nonlymphocytic leukemia. Blood 1983; 61: 439–42.
    • (1983) Blood , vol.61 , pp. 439-442
    • Forman, S.J.1    Spruce, W.E.2    Farbstein, M.J.3
  • 3
    • 0021035301 scopus 로고
    • Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclo-phosphamide
    • Santos GW, Tutschka PJ, Brookmeyer R, et al. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclo-phosphamide. N Engl J Med 1983; 309: 1347–53.
    • (1983) N Engl J Med , vol.309 , pp. 1347-1353
    • Santos, G.W.1    Tutschka, P.J.2    Brookmeyer, R.3
  • 4
    • 0019955820 scopus 로고
    • Bone-marrow transplantation for acute leukaemia in first remission
    • Gale RP, Kay HEM, Rimm AA, Bortin MM. Bone-marrow transplantation for acute leukaemia in first remission. Lancet 1982; 2: 1006–9.
    • (1982) Lancet , vol.2 , pp. 1006-1009
    • Gale, R.P.1    Kay, H.E.M.2    Rimm, A.A.3    Bortin, M.M.4
  • 5
    • 0018917152 scopus 로고
    • Cyclosporin A to prevent graft-versus-host disease in man after allogeneic bone-marrow transplantation
    • Powles RL, Clink HM, Spence D, et al. Cyclosporin A to prevent graft-versus-host disease in man after allogeneic bone-marrow transplantation. Lancet 1980; 1: 327–9.
    • (1980) Lancet , vol.1 , pp. 327-329
    • Powles, R.L.1    Clink, H.M.2    Spence, D.3
  • 6
    • 0021822464 scopus 로고
    • Cyclosporine as prophylaxis for graft-versus-host disease: a randomized study in patients undergoing marrow transplantation for acute nonlymphoblastic leukemia
    • Deeg HJ, Storb R, Thomas ED, et al. Cyclosporine as prophylaxis for graft-versus-host disease: a randomized study in patients undergoing marrow transplantation for acute nonlymphoblastic leukemia. Blood 1985; 65: 1325–34.
    • (1985) Blood , vol.65 , pp. 1325-1334
    • Deeg, H.J.1    Storb, R.2    Thomas, E.D.3
  • 7
    • 0019950807 scopus 로고
    • The treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation
    • Clift RA, Buckner CD, Thomas ED, et al. The treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation. Lancet 1982; 2: 621–3.
    • (1982) Lancet , vol.2 , pp. 621-623
    • Clift, R.A.1    Buckner, C.D.2    Thomas, E.D.3
  • 8
    • 84934705510 scopus 로고
    • Bone marrow transplantation for patients in the chronic phase of chronic granulocytic leukaemia: apparent low incidence of relapse within the first two years post-BMT
    • J.M., Goldman, J.F., Apperley, R.E., Marcus, et al., Bone marrow transplantation for patients in the chronic phase of chronic granulocytic leukaemia: apparent low incidence of relapse within the first two years post-BMT, Exp Hematol, (1985), 13, 14-15
    • (1985) Exp Hematol , vol.13 , pp. 14-15
    • Goldman, J.M.1    Apperley, J.F.2    Marcus, R.E.3
  • 9
    • 0021344640 scopus 로고
    • Allogeneic bone-marrow transplantation for chronic myelogenous leukaemia
    • Speck B, Bortin MM, Champlin R, et al. Allogeneic bone-marrow transplantation for chronic myelogenous leukaemia. Lancet 1984; 1: 665–8.
    • (1984) Lancet , vol.1 , pp. 665-668
    • Speck, B.1    Bortin, M.M.2    Champlin, R.3
  • 10
    • 0019934297 scopus 로고
    • Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase
    • Champlin R, Ho W, Arenson E, Gale RP. Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase. Blood 1982; 60: 1038–41.
    • (1982) Blood , vol.60 , pp. 1038-1041
    • Champlin, R.1    Ho, W.2    Arenson, E.3    Gale, R.P.4
  • 11
    • 85023264059 scopus 로고    scopus 로고
    • Marrow transplantation for the treatment of chronic myelogenous leukemia
    • Ann Intern Med (in press).
    • Thomas ED, Clift RA, Fefer A, et al. Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann Intern Med (in press).
    • Thomas, E.D.1    Clift, R.A.2    Fefer, A.3
  • 12
    • 0021932145 scopus 로고
    • Marrow transplantation for chronic myelocytic leukemia: a controlled trial of cyclosporine versus methotrexate for prophylaxis of graft-versus-host disease
    • Storb R, Deeg HJ, Thomas ED, et al. Marrow transplantation for chronic myelocytic leukemia: a controlled trial of cyclosporine versus methotrexate for prophylaxis of graft-versus-host disease. Blood 1985; 66: 698–702.
    • (1985) Blood , vol.66 , pp. 698-702
    • Storb, R.1    Deeg, H.J.2    Thomas, E.D.3
  • 13
    • 0019390679 scopus 로고
    • Transplantation for acute leukaemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells
    • Reisner Y, Kapoor N, Kirkpatrick D, et al. Transplantation for acute leukaemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells. Lancet 1981; 2: 327–31.
    • (1981) Lancet , vol.2 , pp. 327-331
    • Reisner, Y.1    Kapoor, N.2    Kirkpatrick, D.3
  • 14
    • 0020061303 scopus 로고
    • Pretreatment of donor bone marrow with monoclonal antibody OKT3 for prevention of acute graft-versus-host disease in allogeneic histo-compatible bone-marrow transplantation
    • Filipovich AH, McGlave PB, Ramsay NKC, Goldstein G, Warkentin PI, Kersey JH. Pretreatment of donor bone marrow with monoclonal antibody OKT3 for prevention of acute graft-versus-host disease in allogeneic histo-compatible bone-marrow transplantation. Lancet 1982; 1: 1266–9.
    • (1982) Lancet , vol.1 , pp. 1266-1269
    • Filipovich, A.H.1    McGlave, P.B.2    Ramsay, N.K.C.3    Goldstein, G.4    Warkentin, P.I.5    Kersey, J.H.6
  • 15
    • 0020063202 scopus 로고
    • Use of anti-T-cell monoclonal antibody OKT3 to prevent acute graft-versus-host disease in allogeneic bone-marrow transplantation for acute leukaemia
    • Prentice HG, Blacklock HA, Janossy G, et al. Use of anti-T-cell monoclonal antibody OKT3 to prevent acute graft-versus-host disease in allogeneic bone-marrow transplantation for acute leukaemia. Lancet 1982; 1: 700–3.
    • (1982) Lancet , vol.1 , pp. 700-703
    • Prentice, H.G.1    Blacklock, H.A.2    Janossy, G.3
  • 16
    • 85005160608 scopus 로고
    • Prevention of graft-versus-host disease (GVHD) by ex vivo treatment of donor bone marrow with monoclonal anti-T cell antibody (CT-2) and complement: results of a prospective randomized controlled trial
    • abstract.
    • Mitsuyasu RT, Champlin RE, Ho WG, et al. Prevention of graft-versus-host disease (GVHD) by ex vivo treatment of donor bone marrow with monoclonal anti-T cell antibody (CT-2) and complement: results of a prospective randomized controlled trial. Blood 1984; 64: 218a. abstract.
    • (1984) Blood , vol.64 , pp. 218a
    • Mitsuyasu, R.T.1    Champlin, R.E.2    Ho, W.G.3
  • 17
    • 0021345180 scopus 로고
    • Depletion of T lymphocytes in donor marrow prevents significant graft-versus-host disease in matched allogeneic leukaemic marrow transplant recipients
    • Prentice HG, Blacklock HA, Janossy G, et al. Depletion of T lymphocytes in donor marrow prevents significant graft-versus-host disease in matched allogeneic leukaemic marrow transplant recipients. Lancet 1984; 1: 472–6.
    • (1984) Lancet , vol.1 , pp. 472-476
    • Prentice, H.G.1    Blacklock, H.A.2    Janossy, G.3
  • 18
    • 0021984561 scopus 로고
    • Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts
    • Martin PJ, Hansen JA, Buckner CD, et al. Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood 1985; 66: 664–72.
    • (1985) Blood , vol.66 , pp. 664-672
    • Martin, P.J.1    Hansen, J.A.2    Buckner, C.D.3
  • 19
    • 0022412505 scopus 로고
    • Marrow transplantation for leukemia following fractionated total body irradiation: a comparative trial of methotrexate and cyclosporine
    • Irle C, Deeg HJ, Buckner CD, et al. Marrow transplantation for leukemia following fractionated total body irradiation: a comparative trial of methotrexate and cyclosporine. Leuk Res 1985; 9: 1255–61.
    • (1985) Leuk Res , vol.9 , pp. 1255-1261
    • Irle, C.1    Deeg, H.J.2    Buckner, C.D.3
  • 20
    • 0020084877 scopus 로고
    • Cyclosporin A and methotrexate in canine marrow transplantation: engraftment, graft-versus-host disease, and induction of tolerance
    • H.J., Deeg, R., Storb, P.L., Weiden, et al., Cyclosporin A and methotrexate in canine marrow transplantation: engraftment, graft-versus-host disease, and induction of tolerance, Transplantation, (1982), 34, 30-35
    • (1982) Transplantation , vol.34 , pp. 30-35
    • Deeg, H.J.1    Storb, R.2    Weiden, P.L.3
  • 21
    • 0021327019 scopus 로고
    • Combined immunosuppression with cyclosporine and methotrexate in dogs given bone marrow grafts from DLA-haploidentical littermates
    • H.J., Deeg, R., Storb, F.R., Appelbaum, M.S., Kennedy, T.C., Graham, E.D., Thomas, Combined immunosuppression with cyclosporine and methotrexate in dogs given bone marrow grafts from DLA-haploidentical littermates, Transplantation, (1984), 37, 62-65
    • (1984) Transplantation , vol.37 , pp. 62-65
    • Deeg, H.J.1    Storb, R.2    Appelbaum, F.R.3    Kennedy, M.S.4    Graham, T.C.5    Thomas, E.D.6
  • 22
    • 0019960451 scopus 로고
    • Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse
    • Clift RA, Buckner CD, Thomas ED, et al. Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse. Leuk Res 1982; 6: 401–7.
    • (1982) Leuk Res , vol.6 , pp. 401-407
    • Clift, R.A.1    Buckner, C.D.2    Thomas, E.D.3
  • 23
    • 0017145684 scopus 로고
    • On the use of Pocock and Simon's method for balancing treatment numbers over prognostic factors in the controlled clinical trial
    • Freedman LS, White SJ. On the use of Pocock and Simon's method for balancing treatment numbers over prognostic factors in the controlled clinical trial. Biometrics 1976; 32: 691–4.
    • (1976) Biometrics , vol.32 , pp. 691-694
    • Freedman, L.S.1    White, S.J.2
  • 24
    • 0021684957 scopus 로고
    • Effect of hepatic dysfunction on oral cyclosporine pharmacokinetics in marrow transplant patients
    • Yee GC, Kennedy MS, Storb R, Thomas ED. Effect of hepatic dysfunction on oral cyclosporine pharmacokinetics in marrow transplant patients. Blood 1984; 64: 1277–9.
    • (1984) Blood , vol.64 , pp. 1277-1279
    • Yee, G.C.1    Kennedy, M.S.2    Storb, R.3    Thomas, E.D.4
  • 25
    • 0018220158 scopus 로고
    • Protective environment for marrow transplant recipients
    • Buckner CD, Clift RA, Sanders JE, et al. Protective environment for marrow transplant recipients. Ann Intern Med 1978; 89: 893–901.
    • (1978) Ann Intern Med , vol.89 , pp. 893-901
    • Buckner, C.D.1    Clift, R.A.2    Sanders, J.E.3
  • 26
    • 0016860720 scopus 로고
    • Bone-marrow transplantation
    • 895–902.
    • Thomas ED, Storb R, Clift RA, et al. Bone-marrow transplantation. N Engl J Med 1975; 292: 832–43, 895–902.
    • (1975) N Engl J Med , vol.292 , pp. 832-843
    • Thomas, E.D.1    Storb, R.2    Clift, R.A.3
  • 27
    • 0019452794 scopus 로고
    • Treatment of graft-versus-host disease in human allogeneic marrow graft recipients: a randomized trial comparing antithymocyte globulin and corticosteroids
    • Doney KC, Weiden PL, Storb R, Thomas ED. Treatment of graft-versus-host disease in human allogeneic marrow graft recipients: a randomized trial comparing antithymocyte globulin and corticosteroids. Am J Hematol 1981; 11: 1–8.
    • (1981) Am J Hematol , vol.11 , pp. 1-8
    • Doney, K.C.1    Weiden, P.L.2    Storb, R.3    Thomas, E.D.4
  • 28
    • 0016085576 scopus 로고
    • Treatment of established human graft-versus-host disease by antithymocyte globulin
    • Storb R, Gluckman E, Thomas ED, et al. Treatment of established human graft-versus-host disease by antithymocyte globulin. Blood 1974; 44: 57–75.
    • (1974) Blood , vol.44 , pp. 57-75
    • Storb, R.1    Gluckman, E.2    Thomas, E.D.3
  • 29
    • 0021324095 scopus 로고
    • Murine monoclonal anti-T cell antibodies for treatment of steroid-resistant acute graft-versus-host disease
    • Remlinger K, Martin PJ, Hansen JA, et al. Murine monoclonal anti-T cell antibodies for treatment of steroid-resistant acute graft-versus-host disease. Hum Immunol 1984; 9: 21–35.
    • (1984) Hum Immunol , vol.9 , pp. 21-35
    • Remlinger, K.1    Martin, P.J.2    Hansen, J.A.3
  • 30
    • 0003801716 scopus 로고
    • The design and analysis of sequential clinical trials
    • Chichester, England: Horwood
    • Whitehead J. The design and analysis of sequential clinical trials. Chichester, England: Horwood, 1983.
    • (1983)
    • Whitehead, J.1
  • 31
    • 0000336139 scopus 로고
    • Regression models and life-tables
    • Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972; 34: 187–202.
    • (1972) J R Stat Soc [B] , vol.34 , pp. 187-202
    • Cox, D.R.1
  • 32
    • 0003496954 scopus 로고
    • The statistical analysis of failure time data
    • New York: John Wiley
    • Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data. New York: John Wiley, 1980.
    • (1980)
    • Kalbfleisch, J.D.1    Prentice, R.L.2
  • 33
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457–81.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 34
    • 0021960158 scopus 로고
    • Incidence of hypertension after marrow transplantation among 112 patients randomized to either cyclosporine or methotrexate as graft-versus-host disease prophylaxis
    • Loughran TP Jr, Deeg HJ, Dahlberg S, Kennedy MS, Storb R, Thomas ED. Incidence of hypertension after marrow transplantation among 112 patients randomized to either cyclosporine or methotrexate as graft-versus-host disease prophylaxis. Br J Haematol 1985; 59: 547–53.
    • (1985) Br J Haematol , vol.59 , pp. 547-553
    • Loughran, T.P.1    Deeg, H.J.2    Dahlberg, S.3    Kennedy, M.S.4    Storb, R.5    Thomas, E.D.6
  • 36
    • 0020049270 scopus 로고
    • A randomized study of the prevention of acute graft-versus-host disease
    • Ramsay NKC, Kersey JH, Robison LL, et al. A randomized study of the prevention of acute graft-versus-host disease. N Engl J Med 1982; 306: 392–7.
    • (1982) N Engl J Med , vol.306 , pp. 392-397
    • Ramsay, N.K.C.1    Kersey, J.H.2    Robison, L.L.3
  • 37
    • 0018764352 scopus 로고
    • Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts
    • Weiden PL, Floumoy N, Thomas ED, et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med 1979; 300: 1068–73.
    • (1979) N Engl J Med , vol.300 , pp. 1068-1073
    • Weiden, P.L.1    Floumoy, N.2    Thomas, E.D.3
  • 38
    • 0019861205 scopus 로고
    • Seattle Marrow Transplant Team. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation
    • Weiden PL, Sullivan KM, Floumoy N, Storb R, Thomas ED. Seattle Marrow Transplant Team. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 1981; 304: 1529–33.
    • (1981) N Engl J Med , vol.304 , pp. 1529-1533
    • Weiden, P.L.1    Sullivan, K.M.2    Floumoy, N.3    Storb, R.4    Thomas, E.D.5
  • 39
    • 0021808019 scopus 로고
    • Marrow transplant experience in children with acute lymphoblastic leukemia: an analysis of factors associated with survival, relapse and graft-versus-host disease
    • Sanders JE, Floumoy N, Thomas ED, et al. Marrow transplant experience in children with acute lymphoblastic leukemia: an analysis of factors associated with survival, relapse and graft-versus-host disease. Med Pediatr Oncol 1985; 13: 165–72.
    • (1985) Med Pediatr Oncol , vol.13 , pp. 165-172
    • Sanders, J.E.1    Floumoy, N.2    Thomas, E.D.3
  • 40
    • 0020694110 scopus 로고
    • Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings: beneficial effect of a protective environment
    • Storb R, Prentice RL, Buckner CD, et al. Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings: beneficial effect of a protective environment. N Engl J Med 1983; 308: 302–7.
    • (1983) N Engl J Med , vol.308 , pp. 302-307
    • Storb, R.1    Prentice, R.L.2    Buckner, C.D.3
  • 41
    • 0021141341 scopus 로고
    • Prophylaxis of infection in patients with aplastic anemia receiving allogeneic marrow transplants
    • Navari RM, Buckner CD, Clift RA, et al. Prophylaxis of infection in patients with aplastic anemia receiving allogeneic marrow transplants. Am J Med 1984; 76: 564–72.
    • (1984) Am J Med , vol.76 , pp. 564-572
    • Navari, R.M.1    Buckner, C.D.2    Clift, R.A.3
  • 42
    • 0021068256 scopus 로고
    • Pharmacokinetics and toxicity of cyclosporine in marrow transplant patients
    • Kennedy MS, Yee GC, Deeg HJ, Storb R, Thomas ED. Pharmacokinetics and toxicity of cyclosporine in marrow transplant patients. Transplant Proc 1983; 15: 2416–8.
    • (1983) Transplant Proc , vol.15 , pp. 2416-2418
    • Kennedy, M.S.1    Yee, G.C.2    Deeg, H.J.3    Storb, R.4    Thomas, E.D.5
  • 43
    • 0020586967 scopus 로고
    • Acute renal toxicity with combined use of amphotericin B and cyclosporine after marrow transplantation
    • Kennedy MS, Deeg HJ, Siegel M, Crowley JJ, Storb R, Thomas ED. Acute renal toxicity with combined use of amphotericin B and cyclosporine after marrow transplantation. Transplantation 1983; 35: 211–5.
    • (1983) Transplantation , vol.35 , pp. 211-215
    • Kennedy, M.S.1    Deeg, H.J.2    Siegel, M.3    Crowley, J.J.4    Storb, R.5    Thomas, E.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.