Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure

New England Journal of Medicine

Volumn 314, Issue 24, 1986, Pages 1547-1552

  Cohn, Jay N ^a   Archibald, Donald G ^a   Ziesche, Susan ^a   Franciosa, Joseph A ^a   Harston, W Eugene ^a   Tristani, Felix E ^a   Dunkman, W Bruce ^a   Jacobs, William ^a   Francis, Gary S ^a   Flohr, Kathleen H ^a   Goldman, Steven ^a   Cobb, Frederick R ^a   Shah, Pravin M ^a   Saunders, Robert ^a   Fletcher, Ross D ^a   Loeb, Henry S ^a   Hughes, Vincent C ^a   Baker, Bonnie ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; DIURETIC AGENT; HYDRALAZINE; ISOSORBIDE DINITRATE; PLACEBO; PRAZOSIN;

CLINICAL ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG COMPARISON; DRUG EFFICACY; DRUG MIXTURE; DRUG THERAPY; EPIDEMIOLOGY; HEART; HEART LEFT VENTRICLE PERFORMANCE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MORTALITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBLINGUAL DRUG ADMINISTRATION; THERAPY;

CLINICAL TRIALS; COMPARATIVE STUDY; DRUG THERAPY, COMBINATION; EXERCISE TEST; FOLLOW-UP STUDIES; HEART FAILURE, CONGESTIVE; HEMODYNAMICS; HUMAN; HYDRALAZINE; ISOSORBIDE DINITRATE; MALE; MIDDLE AGE; PRAZOSIN; RANDOM ALLOCATION; SUPPORT, U.S. GOV'T, NON-P.H.S.; VASODILATOR AGENTS;

EID: 0022623381     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198606123142404     Document Type: Article

References (29)

1. Guiha NH, Cohn JN, Mikulic E, Franciosa JA, Limas CJ. Treatment of refractory heart failure with infusion of nitroprusside. N Engl J Med 1974; 291: 587–92.
2. Cohn JN, Franciosa JA. Vasodilator therapy of cardiac failure. N Engl J Med 1977; 297: 27–31, 254–8.
3. Pierpont GL, Cohn JN, Franciosa JA. Combined oral hydralazine–nitrate therapy in left ventricular failure: hemodynamic equivalency to sodium nitroprusside. Chest 1978; 73: 8–13.
4. Awan NA, Needham KE, Evenson MK, Amsterdam EE, Mason DT. Therapeutic application of prazosin in chronic refractory congestive heart failure: tolerance and “tachyphylaxis” in perspective. Am J Med 1981; 71: 153–60.
5. Chatterjee K, Massie B, Rubin S, Gelberg H, Brundage BH, Ports TA. Long-term outpatient vasodilator therapy of congestive heart failure: consideration of agents at rest and during exercise. Am J Med 1978; 65: 134–45.
6. Rubinstein LV, Gail MH, Santner TJ. Planning the duration of a comparative clinical trial with loss to follow-up and a period of continued observation. J Chronic Dis 1981; 34: 469–79.
7. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979; 35: 549–56.
8. Tsiatis AA. The asymptotic joint distribution of the efficient scores test for the proportional hazards model calculated over time. Biometrika 1981; 68: 311–5.
9. Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer 1976; 34: 585–612.
10. Cutler SJ, Ederer F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis 1958; 8: 699–712.
11. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972: 34: 187–202.
12. Dixon WJ, ed. BMDP statistical software. Berkeley, Calif.: University of California Press, 1981:557–75.
13. Cohn JN. Vasodilator therapy for heart failure: the influence of impedance on left ventricular performance. Circulation 1973; 48: 5–8.
14. Miller RR, Awan NA, Maxwell KS, Mason DT. Sustained reduction of cardiac impedance and preload in congestive heart failure with the antihypertensive vasodilator prazosin. N Engl J Med 1977; 297: 303–7.
15. Massie B, Chatterjee K, Werner J, Greenberg B, Hart R, Parmley WW. Hemodynamic advantage of combined administration of hydralazine orally and nitrates nonparenterally in the vasodilator therapy of chronic heart failure. Am J Cardiol 1977; 40: 794–801.
16. Colucci WS, Wynne J, Holman BL, Braunwald E. Long-term therapy of heart failure with prazosin: a randomized double blind trial. Am J Cardiol 1980; 45: 337–44.
17. Franciosa JA, Nordstrom LA, Cohn JN. Nitrate therapy for congestive heart failure. JAMA 1978; 240: 443–6.
18. Leier CV, Huss P, Magorien RD, Unverferth DV. Improved exercise capacity and differing arterial and venous tolerance during chronic isosorbide dinitrate therapy for congestive heart failure. Circulation 1983; 67: 817–22.
19. Fitchett DH, Marin JA, Oakley CM, Goodwin JF. Hydralazine in the management of left ventricular failure. Am J Cardiol 1979; 44: 303–9.
20. Franciosa JA, Weber KT, Levine TB, et al. Hydralazine in the long-term treatment of chronic heart failure: lack of difference from placebo. Am Heart J 1982; 104: 587–94.
21. Packer M, Meiler J, Gorlin R, Herman MV. Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure. Circulation 1979; 59: 531–9.
22. Franciosa JA, Wilen M, Ziesche S, Cohn JN. Survival in men with severe chronic left ventricular failure due to either coronary heart disease or idiopathic dilated cardiomyopathy. Am J Cardiol 1983; 51: 831–6.
23. Massie B, Ports T, Chatterjee K, et al. Long-term vasodilator therapy for heart failure: clinical response and its relationship to hemodynamic measurements. Circulation 1981; 63: 269–78.
24. Wilson JR, Schwartz JS, Sutton MSJ, et al. Prognosis in severe heart failure: relation to hemodynamic measurements and ventricular ectopic activity. J Am Coll Cardiol 1983; 2: 403–10.
25. Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984; 311: 819–23.
26. Franciosa JA, Pierpont G, Cohn JN. Hemodynamic improvement after oral hydralazine in left ventricular failure: a comparison with nitroprusside infusion in 16 patients. Ann Intem Med 1977; 86: 388–93.
27. Franciosa JA, Blank RC, Cohn JN. Nitrate effects on cardiac output and left ventricular outflow resistance in chronic congestive heart failure. Am J Med 1978; 64: 207–13.
28. Chatterjee K, Ports TA, Brundage BH, Massie B, Holly AN, Parmley WW. Oral hydralazine in chronic heart failure: sustained beneficial hemodynamic effects. Ann Intern Med 1980; 92: 600–4.
29. Captopril Multicenter Research Group. A placebo-controlled trial of captopril in refractory chronic congestive heart failure. J Am Coll Cardiol 1983; 2: 755–63.