(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil Derivatives as Potential Conjugated Bioreductive Alkylating Agents

Journal of Medicinal Chemistry

Volumn 29, Issue 1, 1986, Pages 84-89

  Lin, Tai Shun ^a   Sartorelli, Alan C ^a   Wang, Lin ^b   Antonini, Ippolito ^b   Cosby, Lucille A ^b   Shiba, David A ^b   Kirkpatrick, D Lynn ^c  

^a YALE CANCER CENTER   (United States)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF REGINA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 1 (4 NITROBENZYLOXYCARBONYL)URACIL; 5 FLUORO 3 (4 NITROBENZYLOXYCARBONYL)URACIL; ANTINEOPLASTIC AGENT; FLUOROURACIL; FLUOROURACIL DERIVATIVE; NEW DRUG; TEGAFUR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD AND HEMOPOIETIC SYSTEM; CANCER CHEMOTHERAPY; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; EMT 6 TUMOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTOXICATION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA; LEUKEMIA P 388; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SARCOMA; SARCOMA 180; THERAPY;

ANIMALS; CELLS, CULTURED; CHEMISTRY; FLUOROURACIL; LEUKEMIA P388; MICE; NEOPLASMS, EXPERIMENTAL; OXYGEN; SARCOMA 180; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0022617140     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00151a014     Document Type: Article

References (14)

1. Teicher, B.A.; Lazo, J.S.; Sartorelli, A.C. Cancer Res. 1981, 41, 73.
2. Kennedy, K.A.; Rockwell, S.; Sartorelli, A.C. Cancer Res. 1980, 40, 2356.
3. Lin, A.J.; Cosby, L.A.; Shansky, C.W.; Sartorelli, A.C. J. Med. Chem. 1972, 15, 1247.
4. Lin, A.J.; Pardini, R.S.; Cosby, L.A.; Lillis, B.J.; Shansky, C.W.; Sartorelli, A.C. J. Med. Chem. 1973, 16, 1268.
5. Lin, A.J.; Pardini, R.S.; Lillis, B.J.; Sartorelli, A.C. J. Med. Chem. 1974, 17, 558.
6. Lin, A.J.; Pardini, R.S.; Lillis, B.J.; Sartorelli, A.C. J. Med. Chem. 1974, 17, 668.
7. Lin, A.J.; Lillis, B.J.; Sartorelli, A.C. J. Med. Chem. 1975, 18, 917.
8. Lin, A.J.; Sartorelli, A.C. J. Med. Chem. 1976, 19, 1336.
9. Lin, T.S.; Teicher, B.A.; Sartorelli, A.C. J. Med. Chem. 1980, 23, 1237.
10. Antonini, I.; Lin, T.S.; Cosby, L.A.; Dai, Y.R.; Sartorelli, A.C. J. Med. Chem. 1982, 25, 730.
11. Lin, T.S.; Antonini, I.; Cosby, L.A.; Sartorelli, A.C. J. Med. Chem. 1984, 27, 813.
12. Sartorelli, A.C.; Creasey, W.A., In “Cancer Medicine”, 2nd ed.; Holland, J.F., Frei, E., III, Eds.; Lea & Febiger: Philadelphia, 1982; p 720.
13. Carpenter, F.H.; Gish, D.T. J. Am. Chem. Soc. 1952, 74, 3818.
14. Amit, B.; Zehavi, U.; Patchernick, A.J. Org. Chem. 1974, 39, 192.