메뉴 건너뛰기




Volumn 314, Issue 20, 1986, Pages 1298-1304

The Regulation of Hemostasis: The Protein C System

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C;

EID: 0022616976     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198605153142006     Document Type: Review
Times cited : (349)

References (59)
  • 1
    • 85023664362 scopus 로고
    • The known and unknown in blood clotting and thrombosis
    • In: Flynn JE, ed. Blood clotting and allied problems: transaction of the first conference. New York: Josiah Macy, Jr., Foundation
    • Best CH. The known and unknown in blood clotting and thrombosis. In: Flynn JE, ed. Blood clotting and allied problems: transaction of the first conference. New York: Josiah Macy, Jr., Foundation, 1948:26–7.
    • (1948) , pp. 26-27
    • Best, C.H.1
  • 2
    • 0001126659 scopus 로고
    • Activation of purified prothrombin to autoprothrombin II (platelet cofactor II or autoprothrombin II-A)
    • Mammen EF, Thomas WR, Seegers WH. Activation of purified prothrombin to autoprothrombin II (platelet cofactor II or autoprothrombin II-A). Thromb Diath Haemorrh 1960; 5: 218–49.
    • (1960) Thromb Diath Haemorrh , vol.5 , pp. 218-249
    • Mammen, E.F.1    Thomas, W.R.2    Seegers, W.H.3
  • 4
    • 0016365439 scopus 로고
    • The role of fibrin monomer and an in vivo thrombin-induced anticoagulant in experimental venous thrombosis
    • Wetmore R, Gurewich V. The role of fibrin monomer and an in vivo thrombin-induced anticoagulant in experimental venous thrombosis. Scand J Haematol 1974; 12: 204–12.
    • (1974) Scand J Haematol , vol.12 , pp. 204-212
    • Wetmore, R.1    Gurewich, V.2
  • 5
    • 0017283234 scopus 로고
    • A new vitamin K-dependent protein: purification from bovine plasma and preliminary characterization
    • Stenflo J. A new vitamin K-dependent protein: purification from bovine plasma and preliminary characterization. J Biol Chem 1976; 251: 35563.
    • (1976) J Biol Chem , vol.251 , pp. 35563
    • Stenflo, J.1
  • 6
    • 0017164367 scopus 로고
    • Relationship of “new” vitamin K-dependent protein C and “old” autoprothrombin II-A
    • Seegers WH, Novoa E, Henry RL, Hassouna HI. Relationship of “new” vitamin K-dependent protein C and “old” autoprothrombin II-A. Thromb Res 1976; 8: 543–52.
    • (1976) Thromb Res , vol.8 , pp. 543-552
    • Seegers, W.H.1    Novoa, E.2    Henry, R.L.3    Hassouna, H.I.4
  • 7
    • 0017099639 scopus 로고
    • Proteolytic activation of protein C from bovine plasma
    • Kisiel W, Ericsson LH, Davie EW. Proteolytic activation of protein C from bovine plasma. Biochemistry 1976; 15: 4893–900.
    • (1976) Biochemistry , vol.15 , pp. 4893-4900
    • Kisiel, W.1    Ericsson, L.H.2    Davie, E.W.3
  • 8
    • 0017567792 scopus 로고
    • Anticoagulant properties of bovine protein C following activation by thrombin
    • Kisiel W, Can field WM, Ericsson LH, Davie EW. Anticoagulant properties of bovine protein C following activation by thrombin. Biochemistry 1977; 16: 5824–31.
    • (1977) Biochemistry , vol.16 , pp. 5824-5831
    • Kisiel, W.1    Can field WM2    Ericsson, L.H.3    Davie, E.W.4
  • 9
    • 17344376275 scopus 로고
    • Proteolytic inactivation of bovine factor Va by bovine activated protein C
    • abstract.
    • W., Canfield, M., Nesheim, W., Kisiel, K.G., Mann, Proteolytic inactivation of bovine factor Va by bovine activated protein C, Circulation, abstract., (1978), 58, Supplement 2, 11-210
    • (1978) Circulation , vol.58 , pp. 11-210
    • Canfield, W.1    Nesheim, M.2    Kisiel, W.3    Mann, K.G.4
  • 10
    • 0018715761 scopus 로고
    • The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V
    • Walker FJ, Sexton PW, Esmon CT. The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V. Biochim Biophys Acta 1979; 571: 333–42.
    • (1979) Biochim Biophys Acta , vol.571 , pp. 333-342
    • Walker, F.J.1    Sexton, P.W.2    Esmon, C.T.3
  • 11
    • 0018672331 scopus 로고
    • Human plasma protein C: isolation, characterization, and mechanism of activation by a-thrombin
    • Kisiel W. Human plasma protein C: isolation, characterization, and mechanism of activation by a-thrombin. J Clin Invest 1979; 64: 761–9.
    • (1979) J Clin Invest , vol.64 , pp. 761-769
    • Kisiel, W.1
  • 12
    • 0020072618 scopus 로고
    • Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme
    • Marlar RA, Kleiss AJ, Griffin JH. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood 1982; 59: 1067–72.
    • (1982) Blood , vol.59 , pp. 1067-1072
    • Marlar, R.A.1    Kleiss, A.J.2    Griffin, J.H.3
  • 13
    • 0018198558 scopus 로고
    • Properties of the factor Xa binding site on human platelets
    • Miletich JP, Jackson CM, Majerus PW. Properties of the factor Xa binding site on human platelets. J Biol Chem 1977; 253: 6908–16.
    • (1977) J Biol Chem , vol.253 , pp. 6908-6916
    • Miletich, J.P.1    Jackson, C.M.2    Majerus, P.W.3
  • 14
    • 0018710706 scopus 로고
    • Activated protein C inhibits platelet prothrombin-converting activity
    • Comp PC, Esmon CT. Activated protein C inhibits platelet prothrombin-converting activity. Blood 1979; 54: 1272–81.
    • (1979) Blood , vol.54 , pp. 1272-1281
    • Comp, P.C.1    Esmon, C.T.2
  • 15
    • 0019203694 scopus 로고
    • Inhibitory effect of activated protein C on activation of prothrombin by platelet-bound factor Xa
    • Dahlbåck B, Stenflo J. Inhibitory effect of activated protein C on activation of prothrombin by platelet-bound factor Xa. Eur J Biochem 1980; 107: 3315.
    • (1980) Eur J Biochem , vol.107 , pp. 3315
    • Dahlbåck, B.1    Stenflo, J.2
  • 16
    • 0000650903 scopus 로고
    • Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
    • Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA 1981; 78: 2249–52.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 2249-2252
    • Esmon, C.T.1    Owen, W.G.2
  • 17
    • 0020063793 scopus 로고
    • Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C
    • Esmon NL, Owen WG, Esmon CT. Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 1982; 257: 85964.
    • (1982) J Biol Chem , vol.257 , pp. 85964
    • Esmon, N.L.1    Owen, W.G.2    Esmon, C.T.3
  • 18
    • 0020404408 scopus 로고
    • Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation
    • Esmon CT, Esmon NL, Harris KW. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem 1982; 257: 7944–7.
    • (1982) J Biol Chem , vol.257 , pp. 7944-7947
    • Esmon, C.T.1    Esmon, N.L.2    Harris, K.W.3
  • 19
    • 0021916141 scopus 로고
    • Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin
    • Maruyama I, Salem HH, Ishii H, Majerus PW. Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin. J Clin Invest 1985; 75: 987–91.
    • (1985) J Clin Invest , vol.75 , pp. 987-991
    • Maruyama, I.1    Salem, H.H.2    Ishii, H.3    Majerus, P.W.4
  • 21
    • 0021014165 scopus 로고
    • Protein-C: biochemistry, physiology, and clinical implications
    • Esmon CT. Protein-C: biochemistry, physiology, and clinical implications. Blood 1983; 62: 1155–8.
    • (1983) Blood , vol.62 , pp. 1155-1158
    • Esmon, C.T.1
  • 22
    • 0021288149 scopus 로고
    • Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation
    • Maruyama I, Salem HH, Majerus PW. Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation. J Clin Invest 1984; 74: 224–30.
    • (1984) J Clin Invest , vol.74 , pp. 224-230
    • Maruyama, I.1    Salem, H.H.2    Majerus, P.W.3
  • 23
    • 0019791930 scopus 로고
    • Generation of fibrinolytic activity by infusion of activated protein C into dogs
    • Comp PC, Esmon CT. Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest 1981; 68: 1221–8.
    • (1981) J Clin Invest , vol.68 , pp. 1221-1228
    • Comp, P.C.1    Esmon, C.T.2
  • 26
    • 0019332589 scopus 로고
    • Regulation of activated protein C by a new protein: a possible function for bovine protein S
    • Walker FJ. Regulation of activated protein C by a new protein: a possible function for bovine protein S. J Biol Chem 1980; 255: 5521–4.
    • (1980) J Biol Chem , vol.255 , pp. 5521-5524
    • Walker, F.J.1
  • 27
    • 0017337301 scopus 로고
    • A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S
    • Di Scipio RG, Hermodson MA, Yates SG, Davie EW. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S. Biochemistry 1977; 16: 698–706.
    • (1977) Biochemistry , vol.16 , pp. 698-706
    • Di Scipio, R.G.1    Hermodson, M.A.2    Yates, S.G.3    Davie, E.W.4
  • 28
    • 0019849380 scopus 로고
    • Regulation of activated protein C by protein S: the role of phospholipid in factor Va inactivation
    • Walker FJ. Regulation of activated protein C by protein S: the role of phospholipid in factor Va inactivation. J Biol Chem 1981; 256: 11128–31.
    • (1981) J Biol Chem , vol.256 , pp. 11128-11131
    • Walker, F.J.1
  • 29
    • 0040426308 scopus 로고
    • High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein
    • Dahlbåck B, Stenflo J. High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein. Proc Natl Acad Sci USA 1981; 78: 2512–6.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 2512-2516
    • Dahlbåck, B.1    Stenflo, J.2
  • 30
    • 0019166796 scopus 로고
    • Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease
    • Marlar RA, Griffin JH. Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease. J Clin Invest 1980; 66: 1186–9.
    • (1980) J Clin Invest , vol.66 , pp. 1186-1189
    • Marlar, R.A.1    Griffin, J.H.2
  • 31
    • 0020421219 scopus 로고
    • Evidence of normal functional levels of activated protein C inhibitor in combined factor V/VIII deficiency disease
    • Canfield WM, Kisiel W. Evidence of normal functional levels of activated protein C inhibitor in combined factor V/VIII deficiency disease. J Clin Invest 1982; 70: 1260–72.
    • (1982) J Clin Invest , vol.70 , pp. 1260-1272
    • Canfield, W.M.1    Kisiel, W.2
  • 32
    • 0021636795 scopus 로고
    • Activated protein C inhibitor
    • Suzuki K. Activated protein C inhibitor. Semin Thromb Hemost 1984; 10: 154–61.
    • (1984) Semin Thromb Hemost , vol.10 , pp. 154-161
    • Suzuki, K.1
  • 33
    • 0021741031 scopus 로고
    • Studies on human protein C inhibitor in normal and factor V/VIII deficient plasmas
    • Gardiner JE, Griffin JH. Studies on human protein C inhibitor in normal and factor V/VIII deficient plasmas. Thromb Res 1984; 36: 197–203.
    • (1984) Thromb Res , vol.36 , pp. 197-203
    • Gardiner, J.E.1    Griffin, J.H.2
  • 34
    • 0020674167 scopus 로고
    • Protein C inhibitor: purification from human plasma and characterization
    • Suzuki K, Nishioka J, Hashimoto S. Protein C inhibitor: purification from human plasma and characterization. J Biol Chem 1983; 258: 163–8.
    • (1983) J Biol Chem , vol.258 , pp. 163-168
    • Suzuki, K.1    Nishioka, J.2    Hashimoto, S.3
  • 36
    • 0021101168 scopus 로고
    • Congenital protein C deficiency and venous thromboembolism: a study of three Dutch families
    • Broekmans AW, Veltkamp II, Bertina RM. Congenital protein C deficiency and venous thromboembolism: a study of three Dutch families. N Engl J Med 1983; 309: 340–4.
    • (1983) N Engl J Med , vol.309 , pp. 340-344
    • Broekmans, A.W.1    Veltkamp, I.I.2    Bertina, R.M.3
  • 37
    • 0021930913 scopus 로고
    • Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood
    • Marciniak E, Wilson HD, Marlar RA. Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood. Blood 1985; 65: 15–20.
    • (1985) Blood , vol.65 , pp. 15-20
    • Marciniak, E.1    Wilson, H.D.2    Marlar, R.A.3
  • 38
    • 0021086761 scopus 로고
    • Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant
    • Branson HE, Katz J, Marble R, Griffin JH. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant. Lancet 1983; 2: 1165–8.
    • (1983) Lancet , vol.2 , pp. 1165-1168
    • Branson, H.E.1    Katz, J.2    Marble, R.3    Griffin, J.H.4
  • 39
    • 0021343348 scopus 로고
    • Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn
    • Seligsohn U, Berger A, Abend M, et al. Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med 1984; 310: 559–62.
    • (1984) N Engl J Med , vol.310 , pp. 559-562
    • Seligsohn, U.1    Berger, A.2    Abend, M.3
  • 41
    • 0020480778 scopus 로고
    • Protein C concentrates for therapeutic use
    • Bertina RM, Broekmans AW. Protein C concentrates for therapeutic use. Lancet 1982; 2: 1348.
    • (1982) Lancet , vol.2 , pp. 1348
    • Bertina, R.M.1    Broekmans, A.W.2
  • 42
    • 0020655737 scopus 로고
    • Protein C concentrates for therapeutic use
    • Mannucci PM, Viganò S. Protein C concentrates for therapeutic use. Lancet 1983; 1: 875.
    • (1983) Lancet , vol.1 , pp. 875
    • Mannucci, P.M.1    Viganò, S.2
  • 46
    • 0021707112 scopus 로고
    • Radioimmunoassays for protein C and factor X: plasma antigen levels in abnormal hemostatic states
    • Epstein DJ, Bergum PW, Bajaj SP, Rapaport SI. Radioimmunoassays for protein C and factor X: plasma antigen levels in abnormal hemostatic states. Am J Clin Pathol 1984; 82: 573–81.
    • (1984) Am J Clin Pathol , vol.82 , pp. 573-581
    • Epstein, D.J.1    Bergum, P.W.2    Bajaj, S.P.3    Rapaport, S.I.4
  • 47
    • 0021370003 scopus 로고
    • Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex
    • Comp PC, Nixon RR, Esmon CT. Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex. Blood 1984; 63: 15–21.
    • (1984) Blood , vol.63 , pp. 15-21
    • Comp, P.C.1    Nixon, R.R.2    Esmon, C.T.3
  • 48
    • 0013197186 scopus 로고
    • Functional and immunologic studies of protein C in thromboembolic disease
    • abstract.
    • J.H., Griffin, A., Bezeaud, B., Evatt, D., Mosher, Functional and immunologic studies of protein C in thromboembolic disease, Blood, abstract., (1983), 62, Supplement 1, 301a
    • (1983) Blood , vol.62 , pp. 301a
    • Griffin, J.H.1    Bezeaud, A.2    Evatt, B.3    Mosher, D.4
  • 49
    • 0021359471 scopus 로고
    • The use of a functional and immunologic assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency
    • Bertina RM, Broekmans AW, Krommenhoek-van Es C, van Wijngaarden A. The use of a functional and immunologic assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency. Thromb Haemost 1984; 51: 1–5.
    • (1984) Thromb Haemost , vol.51 , pp. 1-5
    • Bertina, R.M.1    Broekmans, A.W.2    Krommenhoek-van Es, C.3    van Wijngaarden, A.4
  • 50
    • 0021612460 scopus 로고
    • Hereditary dysfunctional protein C (protein C Bergamo) and thrombosis
    • Barbui T, Finazzi G, Mussoni L, et al. Hereditary dysfunctional protein C (protein C Bergamo) and thrombosis. Lancet 1984; 2: 819.
    • (1984) Lancet , vol.2 , pp. 819
    • Barbui, T.1    Finazzi, G.2    Mussoni, L.3
  • 51
    • 0019955823 scopus 로고
    • Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation
    • Griffin JH, Mosher DF, Zimmerman TS, Kleiss AJ. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation. Blood 1982; 60: 261–4.
    • (1982) Blood , vol.60 , pp. 261-264
    • Griffin, J.H.1    Mosher, D.F.2    Zimmerman, T.S.3    Kleiss, A.J.4
  • 52
    • 0019977178 scopus 로고
    • Deficiencies of protein C, an inhibitor of blood coagulation
    • Mannucci PM, Vigano S. Deficiencies of protein C, an inhibitor of blood coagulation. Lancet 1982; 2: 463–7.
    • (1982) Lancet , vol.2 , pp. 463-467
    • Mannucci, P.M.1    Vigano, S.2
  • 53
    • 0021863658 scopus 로고
    • Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation
    • Marlar RA, Endres-Brooks J, Miller C. Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation. Blood 1985; 66: 59–63.
    • (1985) Blood , vol.66 , pp. 59-63
    • Marlar, R.A.1    Endres-Brooks, J.2    Miller, C.3
  • 54
    • 0021320040 scopus 로고
    • Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia
    • Rodeghiero F, Mannucci PM, Viganö S, et al. Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia. Blood 1984; 63: 965–9.
    • (1984) Blood , vol.63 , pp. 965-969
    • Rodeghiero, F.1    Mannucci, P.M.2    Viganö, S.3
  • 57
    • 0021720421 scopus 로고
    • Recurrent venous thromboembolism in patients with a partial deficiency of protein S
    • Comp PC, Esmon CT. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med 1984; 311: 1525–8.
    • (1984) N Engl J Med , vol.311 , pp. 1525-1528
    • Comp, P.C.1    Esmon, C.T.2
  • 58
    • 0021741550 scopus 로고
    • Familial protein S deficiency is associated with recurrent thrombosis
    • Comp PC, Nixon RR, Cooper MR, Esmon CT. Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest 1984; 74: 2082–8.
    • (1984) J Clin Invest , vol.74 , pp. 2082-2088
    • Comp, P.C.1    Nixon, R.R.2    Cooper, M.R.3    Esmon, C.T.4
  • 59
    • 0020060771 scopus 로고
    • Identification in vitro of an endothelial cell surface cofactor for antithrombin III: parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium
    • Busch C, Owen WG. Identification in vitro of an endothelial cell surface cofactor for antithrombin III: parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium. J Clin Invest 1982; 69: 726–9.
    • (1982) J Clin Invest , vol.69 , pp. 726-729
    • Busch, C.1    Owen, W.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.