The differential cytotoxicity of RSU 1069: Cell survival studies indicating interaction with DNA as a possible mode of action

British Journal of Cancer

Volumn 53, Issue 3, 1986, Pages 339-344

  Stratford, I J ^a   Walling, J M ^a   Silver, A R J ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 AZIRIDINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 3 AMINOBENZAMIDE; BROXURIDINE; DNA; MISONIDAZOLE; NITROGEN; RADIOSENSITIZING AGENT;

ANIMAL CELL; BIOLOGICAL MODEL; CELL STRAIN V 79; CYTOTOXICITY; DOSE RESPONSE; DRUG COMPARISON; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG SENSITIVITY; HAMSTER CELL; HYPOXIA; IN VITRO STUDY; INTOXICATION; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BENZAMIDES; BROMODEOXYURIDINE; CELL SURVIVAL; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HAMSTERS; MISONIDAZOLE; NAD; OXYGEN; RADIATION-SENSITIZING AGENTS;

EID: 0022613468     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1986.57     Document Type: Article

References (24)

1. ADAMS, G.E., AHMED, I., SHELDON, P.W. & STRATFORD, I.J. (1984a). Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo. Br. J. Cancer, 49, 571.
2. ADAMS, G.E., AHMED, I., SHELDON, P.W. & STRATFORD, I.J. (1984b). RSU 1069, a 2-nitroimidazole containing an alkylating group: High efficiency as a radio- and chemosensitizer in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys., 10, 1653.
3. ADAMS, G.E., FLOCKHART, I.R., SMITHEN, C.E., STRATFORD, I.J., WARDMAN, P. & WATTS, M.E. (1976). Electron-affinic sensitization, VII. A correlation between structure, one-electron reduction potentials and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiat. Res., 67, 9.
4. ADAMS, G.E., STRATFORD, I.J., WALLACE, R.G., WARDMAN, P. & WATTS, M.E. (1980). Toxicity of nitro compounds toward hypoxic mammalian cells: Dependence upon reduction potential. J. Natl Cancer Inst., 64, 555.
5. BEN-HUR, E. & ELKIND, M.M. (1972). Survival response of asynchronous and synchronous Chinese hamster cells exposed to fluorescent light following 5-bromodeoxyuridine incorporation. Mutation Res., 14, 237.
6. BIAGLOW, J.E., VARNES, M.E., CLARK, E.P. & EPP, E.R. (1983). The role of thiols in cellular response to radiation and drugs. Radiat. Res., 95, 437.
7. CLARKE, E.D., WARDMAN, P., WILSON, I. & TATSUMI, K. (1984). Mechanism of the free radical induced chain isomerization of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide. J. Chem. Soc., Perkin II, 1155.
8. CREISSEN, D. & SHALL, S. (1982). Regulation of DNA ligase activity by poly (ADP-ribose). Nature, 296, 271.
9. DJORDJEVIC, B. & SZYBALSKI, W. (1960). Genetics of human cell lines, III. Incorporation of 5-bromo and 5- iododeoxyuridine into the deoxyribonucleic acid of human cells and its effect on radiation sensitivity. J. Exp. Med., 112, 509.
10. EDWARDS, D.I., KNOX, R.J., SKOLIMOWSKI, I.M., ZAHOOR, A. & KNIGHT, R.C. (1984). Photosensitive interaction of RSU 1069 with DNA. Int. J. Radiat. Oncol. Biol. Phys., 10, 1319.
11. GRIFFITH, O.W. (1980). Determination of glutathione and glutathione disulphide using glutathione reductase and 2-vinylpyridine. Anal. Biochem., 106, 207.
12. JACOBSEN, E.L. & JACOBSEN, M.K. (1976). Pyridine nucleotide levels as a function of growth in normal and transformed 3T3 cells. Arch. Biochem. Biophys., 175, 627.
13. SCHINDLER, R., RAMSEIER, L. & GRIEDER, A. (1966). Increased sensitivity of mammalian cell cultures to radiomimetic alkylating agents following incorporation of 5-bromodeoxyuridine into cellular DNA. Biochem. Pharmacol., 15, 2013.
14. SILVER, A.R.J. & O'NEILL, P. (1986). Interaction of the aziridine moiety of RSU 1069 with nucleotides and inorganic phosphate. Implications for alkylating of DNA. Biochem. Pharmac., (In press).
15. SILVER, A.R.J., O'NIELL, P. & JENKINS, T.C. (1985). Inducation of DNA strand breaks by RSU 1069, a nitroimidazole-aziridine radiosensitizer. Biochem. Pharmac., 34, 3537.
16. SKIDMORE, C.J., DAVIES, M.I., GOODWIN, P.M. & 4 others. (1979). The involvement of poly (ADP-ribose) polymerase in the degradation of NAD caused by γ-radiation and N-methyl-N-nitroso-urea. Eur. J. Biochem., 101, 135.
17. SMITH, E., STRATFORD, I.J. & ADAMS, G.E. (1982). The enhancing effect of misonidazole on the response to melphalan of mammalian cells in vitro. Br. J. Cancer, 46, 117.
18. STRATFORD, I.J., ADAMS, G.E., HARDY, C., HOE, S., O'NIELL, P. & SHELDON, P.W. (1984). Thiol reactive nitroimidazoles: Radiosensitization studies in vitro and in vivo. Int. J. Radiat. Biol., 46, 731.
19. STRATFORD, I.J. & ADAMS, G.E. (1977). The effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro 07-0582, on mammalian cells in vitro. Br. J. Cancer, 35, 307.
20. WALLING, J.M., STRATFORD, I.J. & STEPHENS, M. (1984). Chemopotentiation by CB 1954: The importance of post-incubations and the possible involvement of poly (ADP-ribosylation). Int. J. Radiat. Oncol. Biol. Phys., 10, 1661.
21. WARDMAN, P. (1985). Lifetimes of the radical-anions of medically-important nitroaryl compounds in aqueous solutions. Life Chemistry Reports, 3, 22.
22. WHITMORE, G.F. & GULYAS, S. (1986). Studies on the toxicity of RSU 1069. Int. J. Radiat. Oncol. Biol. Phys. (In press).
23. NDUKA, N., SKIDMORE, C.J. & SHALL, S. (1980). Enhancement of cytotoxicity of N-methyl-Nnitrosourea and of γ-irradiation by inhibitors of poly (ADP-ribose) polymerase. Eur. J. Biochem., 105, 525.
24. ROSS, W.C.J. (1962), Biological alkylating agents. Butterworths, London, pp. 1-231.