Neuroleptic Activity of Chiral trans -Hexahydro-γ-carbolines

Journal of Medicinal Chemistry

Volumn 29, Issue 1, 1986, Pages 8-19

  Sarges, Reinhard ^a   Howard, Harry R ^a   Donahue, Kathy M ^a   Welch, Williard M ^a   Dominy, Beryl W ^a   Weissman, Albert ^a   Koe, B Kenneth ^a   Bordner, Jon ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 FLUORO 5 (4 FLUOROPHENYL) 2,3,4,4A,5,9B HEXAHYDRO 1H PYRIDO[4,3 B]INDOLE DERIVATIVE; AMPHETAMINE; ATROPINE; CLOZAPINE; DESIPRAMINE; DEXCLAMOL; FLUTROLINE; HALOPERIDOL; NEUROLEPTIC AGENT; NEW DRUG; PENFLURIDOL; PIQUINDONE; RADIOISOTOPE; SPIPERONE H 3; TETRABENAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL MODEL; BRAIN; CENTRAL NERVOUS SYSTEM; DRUG ANALYSIS; DRUG ANTAGONISM; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; VISUAL SYSTEM;

ANIMALS; CARBOLINES; CHEMISTRY; DEXTROAMPHETAMINE; MALE; MICE; MOLECULAR CONFORMATION; RATS; RATS, INBRED STRAINS; RECEPTORS, DOPAMINE; SPIPERONE; STEREOISOMERISM; STEREOTYPED BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0022591621     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00151a002     Document Type: Article

References (22)

1. Harbert, C.A.; Plattner, J.J.; Welch, W.M.; Weissman, A.; Koe, B.K. Mol. Pharmacol. 1980, 17, 381.
2. Welch, W.M.; Ewing, F.E.; Harbert, C.A.; Weissman, A.; Koe, B.K. J. Med. Chem. 1980, 23, 949.
3. Snyder, S.; Greenberg, D.; Yamamura, H. Arch. Gen. Psychiat. 1974, 31, 58.
4. Miller, R.; Hiley, C.R. Nature (London) 1974, 248, 596.
5. Sastry, R.V.R. In “Burgers Medicinal Chemistry”, 3rd ed.; Wiley: New York, 1970; p 1544.
6. Bird, P.H.; Bruderlein, F.T.; Humber, L.G. Can. J. Chem. 1976, 54, 2715.
7. Phillip, A.H.; Humber, L.G.; Voith, K. J. Med. Chem. 1979, 22, 768.
8. Froimowitz, M.; Matthysse, S. Mol. Pharmacol. 1983, 24, 243.
9. Pugsley, T.A.; Lippmann, W. J. Pharm. Pharmacol. 1979, 31. 47.
10. Olson, G.L.; Cheung, H.-C.; Chiang, E.; Berger, L. In “Dopamine Receptors”, ACS Symp. Ser.; Kaiser, C., Kebabian, J.W., Ed.; American Chemical Society: Washington, DC, 1983; p 251.
11. Olson, G.L.; Cheung, H.-C.; Morgan, K.D.; Blount, J.F.; Todaro, L.; Berger, L.; Davidson, A.B.; Boff, E. J. Med. Chem. 1981, 24, 1026.
12. Bogeso, K.P. J. Med. Chem. 1983, 26, 935.
13. Chrzanowski, F.A.; McGrogan, B.A.; Maryanoff, B.E. J. Med. Chem. 1985, 28, 399.
14. Welch, W. Patent 4 224 329.
15. Pielichowski, J. Rocz. Chem. 1968, 42, 591.
16. Chem. Abstr. 62, 14612d.
17. Bald, E.; Saigo, K.; Mukaiyama, T. Chem. Lett. 1975, 1163.
18. Stewart, R.F.; Davidson, E.R.; Simpson, W.T. J. Chem. Phys. 1965, 42, 3175.
19. Duchamp, D. J. Am. Cryst. Assoc. Meeting, 1964, B-14, p 29.
20. Ibers, J.; Hamilton, W.C. Acta Crystallogr. 1964, 17, 781.
21. Hamilton, W.C. Acta Crystallogr. 1965, 18, 502.
22. Weissman, A.; Koe, B.K.; Tenen, S.S. J. Pharmacol. 1966, 151, 339.