Nonintercalating DNA-binding ligands: Specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material

Progress in Biophysics and Molecular Biology

Volumn 47, Issue 1, 1986, Pages 31-112

  Zimmer, Christoph ^a   Wähnert, Ulla ^a  

^a Saxonian Academy of Sciences   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAMYCIN; ANTINEOPLASTIC ANTIBIOTIC; BISBENZIMIDE; CONGOCIDINE; DIAGNOSTIC AGENT; DIMINAZENE; DIMINAZENE ACETURATE; DISTAMYCIN A; DNA; DRUG DERIVATIVE; KITASAMYCIN DERIVATIVE; LIGAND; MITHRAMYCIN; NSC 101327; PYRIDINIUM DERIVATIVE; RACHELMYCIN; RNA; SIBIROMYCIN;

ANIMAL; BINDING SITE; BIOSYNTHESIS; CATTLE; CHEMICAL STRUCTURE; CHROMOSOME; CIRCULAR DICHROISM; DENSITY GRADIENT CENTRIFUGATION; DNA SUPERCOILING; DRUG INTERACTION; MATHEMATICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PROTEIN CONFORMATION; REVIEW; STAINING; THERMODYNAMICS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMAL; ANTHRAMYCIN; ANTIBIOTICS, ANTINEOPLASTIC; BASE SEQUENCE; BINDING SITES; BISBENZIMIDE; CATTLE; CENTRIFUGATION, DENSITY GRADIENT; CHEMISTRY, PHYSICAL; CHROMOSOMES; CIRCULAR DICHROISM; DIMINAZENE; DISTAMYCINS; DNA; DNA, SUPERHELICAL; DRUG INTERACTIONS; LEUCOMYCINS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MATHEMATICS; MODELS, MOLECULAR; NETROPSIN; PLICAMYCIN; PROTEIN CONFORMATION; PYRIDINIUM COMPOUNDS; RNA; SPECTROPHOTOMETRY, ULTRAVIOLET; STAINING AND LABELING; THERMODYNAMICS;

EID: 0022587259     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0079-6107(86)90005-2     Document Type: Review

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204. 1
205. Calorimetric and spectroscopic investigation of drug-DNA interactions. I. The binding of netropsin to poly d(AT)
206. Calorimetric and spectroscopic investigation of drug-DNA interactions: II. Dipyrandium binding to poly d(AT)
207. Thermodynamics of drug-DNA interactions
208. Conformational features of distamycin-DNA and netropsin-DNA complexes by Raman spectroscopy
209. 1065 (NSC-298223), a potent new antitumor agent—improved production and isolation, characterization and antitumor activity
210. 125I-labelled DNA ligand to probe DNA structure
211. Some evidence for interaction of d-cycloserine with DNA
212. The use of netropsin with CsCl gradients for the analysis of DNA and its application to restriction nuclease fragments of ribosomal DNA from Physarum polycephalum
213. Cat satellite DNA. Isolation using netropsin with CsCl gradients
214. Characterization of the canine karyotype by counterstain-enhanced chromosome banding
215. Interaction of diamidino-2-phenylindole (DAPI) with natural and synthetic nucleic acids
216. Interaction between DNA and distamycin A studied by transformation in Bacillus subtilis
217. Theoretical calculations of the helix-coil transition of DNA in the presence of large, cooperative binding ligands
218. Accessibility of the minor groove of DNA in chromatin to the binding of antibiotics metropsin and distamycin A
219. Sturcture of sibiromycin
220. Mechanism of AT base pairs recognition by the dye Hoechst 33258
221. Molecular mechanism of action of diaminephenylindole (DAPI). II. Effect of DAPI on the template activity of DNA and polydeoxynucleotides in the DNA-polymerase system from bacteria, eukaryotic cells and RNA tumor viruses
222. Interaction of 4′-6-diamidino-2-phenylindole to nucleic acids and its implication to their template activity in RNA polymerase reaction of E.coli bacteria and of Friend-virus infected mouse spleen
223. Reversion of the B to A transition of DNA induced by specific interaction with the oligopeptide distamycin A
224. Chromomycin, olivomycin and bleomycin as inhibitors of DNA and RNA polymerases
225. Interactions of heterochromatic compounds with nucleic acids. A·T-specific non-intercalating DNA ligands
226. Distamycin: an inhibitor of DNA-dependent nucleic acid synthesis
227. Influence of template inactivators on the binding of DNA polymerase to DNA
228. Potentiation of the effectiveness of bleomycin by A·T-specific DNA ligands in vitro as well as in vivo
229. On the structure of netropsin
230. Alteration of restriction endonuclease cleavage frequency
231. Cooperative interactions between analogs of distamycin A bound on DNA
232. Cooperative effects on binding of large ligands to DNA. I. Long-range cooperative interactions between bound ligand molecules
233. Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex
234. The molecular basis for the action of some DNA-binding drugs
235. X-ray crystallographic studies of nucleic acids and nucleic acid-drug complexes
236. Antitumor activity and acute toxicity of CC-1065 (NSC-298223) in the mouse
237. The interaction of acridine dyes: An X-ray diffraction and optical investigation
238. Interaction of berenil with DNA and some characteristics of the berenil-DNA complex
239. Berenil: A trypanocide with selective activity against extranuclear DNA
240. Structure of restriction endonuclease MboI cleavage sites protected by actinomycin D or distamycin A
241. Mode of action of tomaymycin
242. Binding of methyl green to DNA analyzed by linear dichroism
243. Protection of particular endonuclease R Hind III cleavage sites by distamycin A, propyldistamycin and netropsin
244. Protection of particular cleavage sites of restriction endonucleases by distamycin A and actinomycin D
245. Promotor helical structure variation at the E.coli polymerase interaction sites
246. Structural studies of protein-nucleic acid interactions
247. Kinetics for exchange of the imino protons of the d(CGCGAATTCGCG) double helix in complexes with the antibiotics netropsin and/or actinomycin
248. Netropsin·dGdGdAdAdTdTdCdC complex. Antibiotic binding at adenine·thymine base pairs in the minor groove of the self-complementary octanucleotide duplex
249. Nuclear Magnetic Resonance studies of drug-nucleic acid interactions at the synthetic DNA level in solution
250. Structure and dynamics of poly(dG-dC) in solution steroid diamine-nucleic acid complexes and generation of an “alternating B-DNA” conformation in high salt
251. Mutual interaction between adjacent dG·dC actinomycin binding sites and dA·dT netropsin binding sites on the self-complementary d(CGCGAATTCGCG) duplex in solution
252. Antibiotic-DNA interactions: Intermolecular nuclear Overhauser effects in the netropsin d(CGCGAATTCGCG) complex in solution
253. Netropsin-poly(dA-dT) complex in solution Structure and dynamics of antibiotic-free base pair regions and those centered on bound netropsin
254. Steroid diamino-nucleic acid interactions: Partial insertion of dipyrandium between unstacked base pairs of the poly(dA-dT) duplex in solution
255. Mutual interaction between adjacent dG·dC actinomycin binding sites and dA·dT netropsin binding sites on the self-complementary d(CGCGAATTCGCG) duplex in solution
256. Right-handed alternating DNA conformation: Poly(dA-dT) adopts the same dinucleotide repeat with cesium, tetraalkylammonium, and 3α,5β,17β-dipyrrolidinium steroid dimethiodide cations in aqueous solution
257. DNA conformation, dynamics and interactions in solution
258. Sequence dependence of DNA conformation, dynamics and interactions in solution
259. Sequence dependence of DNA conformation, dynamics and interactions in solutions
260. The organization of highly repeated DNA sequences in Drosophila melanogaster chromosomes
261. Distamicina A. Nota II. Sintesi totale
262. Characterization of Drosophila heterochromatin. II. C- and N-banding
263. Structure of a DNA:DNA-binding fluorochrome complex: CGCGAATTCGCG:Hoechst 33258
264. Circular dichroism of DNA-proflavine, DNA-ethidium and DNA-distamycin flow-oriented complexes
265. Regulation of restriction endonuclease activity with antibiotics
266. Effects of distamycin A on human leukocytes in vitro
267. Nature of interaction of antitumor antibiotic mithramycin with DNA
268. Electrostatics and specificity in nucleic acid reactions
269. Structural factors involved in the binding of netropsin and distamycin A to nucleic acids
270. Factors governing the recognitory interaction of nonintercalating ligands with DNA
271. Theoretical studies of the polymorphism and microheterogeneity of DNA
272. Effect of distamycin A on the template activity of DNA in a DNA polymerase system
273. Effect of distamycin A on T4-DNA-directed RNA synthesis
274. Interaction of non-intercalative drugs with DNA: Distamycin analogues
275. Studies on carcinogen chromatin-DNA interaction: Inhibition of N-methyl-N-nitrosourea-induced methylation of chromatin-DNA by spermine and distamycin A
276. Carcinogen-DNA interaction: Differential effects of distamycin A and spermine on the formation of 7-methylguanine in DNA by N-methyl-N-nitrosourea, methylmethanesulfonate, and dimethylsulfate
277. Coplanare Hetero-oligobasen (Phthalanilide), hochaktive Cytostatika
278. Adenosine·thymine cluster-specific elongation adn stiffening of DNA induced by the oligopeptide antibiotic netropsin
279. DNA secondary structure modulation; interaction of the A·T cluster-specific oligopeptide antibiotic netropsin with very A·T-rich DNA
280. Hydrodynamic properties and conformational changes of linear native DNA
281. Interaction of the oligopeptides distamycin and actinomycin D with DNA; viscometric criteria for binding and bending
282. Aspects of specific DNA-protein interaction; local bending of DNA molecules by in-register binding of the oligopeptide antibiotic distamycin
283. Conformational changes of DNA by interactions with oligopeptide antibiotics as studied by viscometric investigations
284. Aspects of specific protein-DNA interaction; multi-mode binding of the oligopeptide antibiotic netropsin to (A·T) rich DNA segments
285. Counterion dependent variation of DNA secondary structure in (A·T) clusters; evidence by use of netropsin as a structural probe
286. Temperature mediated variation of DNA secondary structure in (A·T) clusters; evidence by use of the oligopeptide antibiotic netropsin as a structural probe
287. Aureolic acid group
288. Bis-netropsin as a selective inhibitor of DNA dependent RNA synthesis
289. A comparison of the requirements for antitumour activity and antibacteriophage lambda activity for a series of nonintercalactive DNA-binding agents
290. Effect of Hoechst 33258 on chinese hamster chromosomes
291. Simultaneous R-banding and localization of AT-clusters in human chromosomes
292. Chromosome banding by in vitro exposure to dA-dT probes and BUdR. Relationships between DNA base clusters, replication pattern, and banding
293. phe
294. Energy transfer and binding competition between dyes used to enhance staining differentiation in metaphase chromosomes
295. Compactization of two-chain DNA as means in determination of its antibiotic binding constant
296. Reverse banding on chromosomes produced by a guanosine-cytosine specific DNA binding antibiotic: olivomycin
297. Netropsin specifically recognizes one of the two conformationally equivalent strands of poly(dA)·poly(dT). One dimensional NMR study at 500 MHz involving NOE transfer between netrospin and DNA protons
298. Complex formation with DNA and inhibition of nucleic acid synthesis by methylglyoxdal bis(guanylhydrazone)
299. On the mechanism of the methyl green-pyronine stain for nucleic acids
300. Inhibition of the Q-bands on human chromosomes by netropsin
301. Studies on the substrate specificity of the DNA methylase activity from Escherichia coli K-12
302. Structure and variability of human chromosomes analyzed by recent techniques
303. Die Bänderung der Chromosomen
304. Mithramycin and DIPI: A pair of flurochromes specific for GC- and AT-rich DNA respectively
305. Effects of counterstaining with DNA binding drugs on fluorescent banding patternsm of human and mammalian chromosomes
306. 3, distamycin A, DAPI and D287/170
307. +
308. Sequence specific double strand cleavage of DNA by penta-N-methyl-pyrrolecarboxamide-EDTA · Fe(II)
309. Sequence-specific double-strand cleavage of DNa by bis(EDTA-distamycin · FeII) and EdTA-bis(distamycin) · FeII
310. Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA · Fe(II) footprinting and DNA affinity cleaving
311. Design and synthesis of a sequence-specific DNA cleaving molecule
312. Reverse fluorescent chromosome banding with chromomycin and DAPI
313. Simultaneous fluorescent staining of R bands and specific heterochromatic regions (DA-DAPI bands) in human chromosomes
314. Review article counterstain-enhanced chremosome banding
315. Distamycin-DAPI bands: properties and occurrence in species
316. Heterochromatin diversity in Cymbidium and its relationship to differential replication
317. Modification of DAPI banding on human chromosomes by prestaining with a DNA-binding oligopeptide antibiotic, distamycin A
318. Sequence-specific recognition of double helical nucleic acids by proteins
319. Enhancement of S1-nuclease suseptibility of negatively superhelical DNA by netropsin
320. Genetic and physiological studies on the site of action of distamycin A
321. Irehdiamine and malouetine
322. Studies on the formation of phthalanilide-DNA complexes and their relationship to chemotherapeutic activity
323. Specific protection of DNA form DNAase I action by distamycin A, netropsin and bis-netropsins
324. 3, mithramycin and olivomycin: Antitumor antibiotics of related structure
325. Interaction of steroid hormone receptors with DNA
326. Reversible inhibition of DNA virus replication with mithramycin
327. Kinetics of DNA-distamycin A AT-specific complex formation
328. Production of positively supercoiled DNA by netropsin
329. Supercoiling and the mechanism of restriction endonucleases
330. Visualization of drug-nucleic acid interactions at atomic resolution. III. Unifying structural concepts in understanding drug-DNA interactions and their broader implication in understanding protein-DNA interactions
331. Light scattering of DNA-netropsin complexes
332. Untersuchungen zur kompetitiven Wechselwirkung
333. Specific interaction between oligovaline and double-stranded nucleic acids
334. Interaction between hydroxystilbamidine and DNA. II. Temperature jump relaxation study. Dynamics of nucleic acids and polynucleotides
335. Nucleotide sequence specificity of DNA cleavage by ironbleomycin
336. Anthramycin inhibition of restriction endonuclease cleavage and its use as a reversible blocking agent in DNA constructions
337. Magnetic circular dichroism of netropsin and natural circular dichroism of the netropsin-DNA complex
338. Netropsin: Interaction with ultraviolet irradiated DNA
339. Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22 and 17q12
340. Oriented complexes of nucleic acids with small ligands. I. Anisotropy of absorbance of the DNA complex with distamycin and its analogs
341. Mechanism of interaction of CC-1065 (NSC298223) with DNA
342. DNA-binding proteins
343. Sequence specific binding of drugs to DNA
344. Enhancement of buoyant separations between DNAs in preparative CsCl gradients containing distamycin distamycin A or netropsin
345. Enhancement of buoyant separations between DNAs in preparative CsCl gradients containing distamycin distamycin A or netropsin
346. DNA affinity cleaving. Sequence specific cleavage of DNA by distamycin-EDTA. Fe(II)
347. Studies on the cleavage of bacteriophage lambda DNA with EcoRI restriction endonuclease
348. Eine neue, von einer Spezies der Streptomyces-reticuli-Gruppe gebildete Antibiotikakombination
349. Localization of AT-clusters in normal mouse chromosomes by netropsin prefixation treatment in vitro
350. Structural modification induced in Chinese hamster V79-E chromosomes by prefixation treatment in vitro with AT-specific agents netropsin, distamycin A, and Hoechst 33258
351. Molecular mechanism of chemical mutagenesis: 9-aminoacridine inhibits DNA replication in vitro by destabilizing the DNA growing point and interacting with the DNA polymerase
352. Interaction of nucleic acids I Physical binding of thymine adenine steroids and aromatic hydrocarbons to nucleic acids
353. 1H-NMR spectroscopy
354. 2-ethanol, is biologically active
355. Differential fluorescent labelling of chromosomes and DNA with base pair specific DNA binding antibiotics. Human cytogen
356. Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous DNA. Footprinting with (methidiumpropyl-EDTA) iron (II)
357. Methidiumpropyl-EDTA · Fe(II) and DNase I footprinting report different and molecule binding site sizes on DNA
358. Footprinting with MPE · Fe(II). Complementary-strand analyses of distamycin- and actinomycin-binding siteson heterogeneous DNA
359. Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage—inhibition patterns with methidiumpropyl-EDTA · Fe(II)
360. On the molecular bases of the specificity of interaction of trancriptional proteins with genome DNA
361. Protein-nucleic Acid interactions in transcription A molecular analysis
362. Identification and separation of components of cald thymus DNA using a CsCl-netropsin density gradient
363. Binding of netropsin to DNA in complexes with polypeptides containing repetitive lysine sequences
364. Interaction between the non-intercalating antitumor drug NSC-101327 and nucleic acids
365. (dA · dT)-dependent inactivation of the DNA template properties by interaction with netropsin and distamycin A
366. The structure of antibiotic T-1384
367. Molecular structure of a left-handed double helical DNA fragment at atomic resolution
368. Base specificity in the interaction of polynucleotides with antibiotic drugs
369. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation
370. DNA modification and cancer
371. Inhibitors of nucleic acid synthesis
372. Uncoiling of bacteriophage PM2 DNA by binding of steroidal diamines
373. Stereochemical aspects of the interaction between steroidal diamines and DNA
374. Netropsin: A specific probe for A-T regions of duplex deoxyribonucleic acid
375. The compatibility of netropsin and actinomycin binding to natural deoxyribonucleic acid
376. Sinanomycin (Netropsin) produced by Streptomyces
377. Fluorimetric properties of the bisbenzimidazole derivative Hoechst 33258, a fluorescent probe specific for AT concentration in chromosomal DNA
378. Studies on synthesis and CD properties of complementary and self-complementary deoxyoligonucleotides
379. DNA structure and gene regulation
380. Hedamycin and rubiflavin complexes with deoxyribonucleic acid and other polynucleotides
381. Selective binding of actinomycin D and distamycin A to DNA
382. Effect of intercalating and groove-binding ligands on formation of covalent complexes between nitracrine (ledakrin, C-283) or 8-methoxypsoralen and DNA
383. Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitro
384. The phthalanilides
385. Indirect selection for auxotrophic mutants of Saccharomyces cerevisiae using the antibiotic netropsin
386. Sequence-specific recognition of B-DNA by oligo (N-methylpyrrolecarboxamide)s
387. A theoretical evaluation of the effect of netropsin binding on the reactivity of DNA towards alkylating agents
388. Phe
389. Theoretical studies of the selective binding to DNA of two non-intercalating ligands: netropsin and SN18071
390. The solvation contribution to the binding energy of DNA with nonintercalating antibiotics
391. A polycationic amine that induced unique conformational changes in poly(dA-dT) in low salt
392. Binding of netropsin to DNA and synthetic polynucleotides
393. Stereochemical model of the molecular mechanism of recognition of AT pairs through interaction with DNA of the antibiotics distamycin A and netropsin
394. A stereochemical model for molecular mechanism of AT pair recognition exhibited by binding of distamycin A and netropsin to DNA
395. Mechanism of recognition of A · T pairs in DNA by Hoechst 33258
396. Ligand-DNA recognition: Molecular mechanism of AT-specific binding of dye “Hoechst 33258” to DNA
397. Use of actinomycin D for the specific quenching of fluorescence of DNA in cells stained with acridine aminoderivatives
398. Selective binding of netropsib and distamycin A to DNA and some consequences for the DNA template activity
399. Effects of the antibiotics netropsin and distamycin A on the structure and function of nucleic acids
400. Molecular aspects of the specific interaction of nonintercalating oligopeptide antibiotics with DNA
401. Optical rotatory dispersion properties of nucleic acid complexes with the oligopeptide antibiotics distamycin A and Netropsin
402. Stability and dissociation of the DNA complexes with distamycin A and netropsin in the presence of organic solvents, urea and high salt concentration
403. Elements of specific recognition of non-intercalating ligands in the interaction with DNa
404. Interaction of streptothricin and related antibiotics with nucleic acids
405. Einfluβ von Netropsin und Distamycin A auf die zellfreie Proteinsynthese und die Struktur der Nucleinsäuren
406. Changes in the DNA secondary structure by interaction with oligopeptide antibiotics: Thermal melting, ORD and CD of DNA complexes with netropsin and distamycin A derivatives
407. Influence of netropsin and distamycin A on the secondary structure and templete activity of DNA
408. Interaction of the oligopeptide antibodies netropsib and distamycin A with nucleic acids
409. Binding of analogues of the antibiotics distamycin A and netropsin to native DNA. Effect of chromophore systems and basic residues of the oligopeptides on thermal stability, conformation and template activity of the DNA complexes
410. Duplex structure formation between oligo(dA)'s and oligo(dT)'s generated by thymine-specific interaction with netropsin
411. Approach to the analysis of decondensed DNA structural regions in chromatin using netropsin as a probe
412. Influence of nucleotide sequence on dA · dT-specific binding of netropsin to double-stranded DNA
413. Interaction of netropsin with ultraviolet-light irradiated DNA and poly(dA) · poly(dT)
414. Recognition of the DNA double-helix by model ligopeptides and implications for protein interactions
415. Magnetic circular dichroism study of analogues of the DNa binding ligands netropsin and distamycin A
416. Magnetic circular dichroism study of the binding of netropsin and distamycin A with DNA
417. Protection of (dA · dT) cluster regions in the DNAase I cleavage of DNA by specific interaction with netropsin
418. n
419. Chain length-dependent association of distamycin-type oligopeptides with A · T and G · D pairs in polynucleotide duplexes
420. Z-DNA and other non-B-DNA structures are reversed to B-DNA by interaction with netropsin
421. Divergent affinity of netropsin-type nonintercalators and bisquaternary ammonium heterocyclic drugs towards DNa
422. Studies on the interaction of distamycin A and its derivatives with DNA