Glucocorticoid receptors and depression

British Medical Journal (Clinical research ed.)

Volumn 292, Issue 6524, 1986, Pages 859-861

  Whalley, L J ^a   Borthwick, N ^a   Copolov, D ^a   Dick, H ^a   Christie, J E ^a   Fink, G ^a  

^a ROYAL EDINBURGH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE H 3; GLUCOCORTICOID RECEPTOR; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD AND HEMOPOIETIC SYSTEM; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DIAGNOSIS; HUMAN; HUMAN CELL; HYDROCORTISONE BLOOD LEVEL; LYMPHATIC SYSTEM; LYMPHOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; SCHIZOPHRENIA;

ADULT; DEPRESSION; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; RECEPTORS, GLUCOCORTICOID; SCHIZOPHRENIA;

EID: 0022579038     PISSN: 02670623     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.292.6524.859     Document Type: Article

References (17)

1. Christie, J.E., Whalley, L.J., Dick, H., Blackwood, D.H.R., Blackburn, I.M., Fink, G. Raised plasma cortisol concentrations are a feature of drug-free psychotics and are not specific for depression. Br J Psychiatry 1986;148:58–65.
2. Wing, J.K., Cooper, J.E., Sartorius, N. The measurement and classification of psychiatric symptoms. London: Cambridge University Press, 1974.
3. Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.
4. Spitzer, R.L., Endicott, J., Robins, E. Research Diagnostic Criteria: rationale and reliability. Arch Gen Psychiatry 1978;35:773–782.
5. Boyum, A. Separation of leukocytes from blood and bone marrow. Scandinavian Journal of Clinical Investigation 1968;21 (suppl 97): 1–107.
6. Scatchard, G. The attractions of proteins for small molecules and ions. Ann NY Acad Sci 1949;51:660–672.
7. Seth, J., Brown, L.M. A simple radioimmunoassay for plasma cortisol. Clin Chim Acta 1978;86:109–120.
8. Halbreich, U., Asnis, G., Shindledecker, R., Zumoff, B., Nathan, S. Cortisol secretion in endogenous depression. II. Time-related functions. Arch Gen Psychiatry 1985;42:909–914.
9. Bar, R.S., Roth, J. Insulin receptor status in disease states of man. Arch Intern Med 1977;137:474–479.
10. Janne, O., Kontula, K., Vihko, R., Feil, P.D., Bardin, C.W. Progesterone receptor and regulation of progestin action in mammalian tissues. Med Biol 1978;56:225.
11. Kontula, K., Pelkonen, R., Andersson, L., Siuula, A. Glucocorticoid receptors in adrenocorticoid disorders. J Clin Endocrinol Metab 1980;51:654–657.
12. Kontula, K., Andersson, L.C., Huttenen, M., Pelkonen, R. Reduced level of cellular glucocorticoid receptors in patients with anorexia nervosa. Harm Metab Res 1982;14:619–620.
13. Chrousos, G.P., Loriaux, D.L., Brandon, D., et al. Primary cortisol resistance: a familial syndrome and an animal model. J Steroid Biochem 1983;19:567–575.
14. Kraft, N., Hodgson, A.J., Funder, J.W. Glucocorticoid receptor and effector mechanisms: a comparison of the corticosensitive mouse with the corticoresistant guinea pig. Endocrinology 1979;104:344–349.
15. Lowy, M.T., Reder, A.T., Antel, J.P., Meltzer, H.Y. Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone. Am J Psychiatry 1984;141:1365–1367.
16. Sapolsky, R.M., Krey, L.C., McEwen, B.S. Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response. Proc Nail Acad Sci USA 1984;81:6174–6177.
17. Angelucci, L., Patacchioli, F.R., Bohus, B., De Kloet, R. Serotoninergic innervation and glucocorticoid binding in the hippocampus: relevance to depression. In: Costa E, Racagni G, eds. Typical and atypical antidepressants: molecular mechanisms. New York: Raven Press, 1982:365–370.