The effect of hydrophilic coatings on the uptake of colloidal particles by the liver and by peritoneal macrophages

International Journal of Pharmaceutics

Volumn 29, Issue 1, 1986, Pages 53-65

  Ilium, L ^a   Hunneyball, I M ^b   Davis, S S ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b The Boots Company PLC   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

colloidal particles; egg lecithin; gamma scintigraphy; hydrophilic coating; phagocytosis; poloxamer 188 and 338; polystyrene microspheres; secretory immunoglobulin A

Indexed keywords

PHOSPHATIDYLCHOLINE; POLOXAMER; RADIOISOTOPE; SECRETORY IMMUNOGLOBULIN;

ANIMAL EXPERIMENT; BLOOD AND HEMOPOIETIC SYSTEM; DRUG BLOOD LEVEL; DRUG COMPARISON; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG MONITORING; DRUG TISSUE LEVEL; HISTOLOGY; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM; PHAGOCYTOSIS; POLYSTYRENE I 131; PRIORITY JOURNAL; RABBIT;

EID: 0022575970     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(86)90199-7     Document Type: Article

References (30)

1. Therapeutic potential of liposomes as carriers in leishmaniasis, malaria and vaccines
2. Effect of pH on the adsorption of immunoglobulin G on anionic poly(vinyltoluene) model latex particles
3. Human secretory component. II. Physicochemical characterization of free secretory component purified from colostrum
4. The stability of fat emulsions for parenteral nutrition
5. The influence of emulsifying agents on the phagocytosis of lipid emulsions by macrophages
6. The hydrophobic effect and charge effects in the adhesion of enterobacteria to animal cell surfaces and the influences of antibodies of different immunoglobulin classes
7. Studies on the metabolism of intravenous fat emulsion
8. Effect of the nonionic surfactant poloxamer 338 on the fate and deposition of polystyrene microspheres following intravenous administration
9. The organ uptake of intravenously administered colloidal particles can be altered using a non- ionic surfactant (poloxamer 338)
10. The targeting of drugs parenterally by use of microspheres
11. Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape
12. The influence of emulsifying agents and of lipid soluble drugs on the fractional removal rate of lipid emulsion from the blood stream of the rabbit
13. Adsorption characteristics of certain polyoxyethylene-polyoxypropylene block co-polymers on polystyrene latex
14. Studies on human secretory IgA. Comparative studies on the IgA-bund secretory piece and the free secretory piece protein
15. 14]-methacrylate nanoparticles after intravenous injections in rats
16. Reduction of phagocytosis, surface hydrophobicity and charge of Salmonella typhimurium 395 MR10 by reaction with secretory IgA (SIgA)
17. Studies of the steric stabilisation of colloidal particles
18. Adsorption of proteins at solid surfaces
19. Site specific (targeted) drug delivery in cancer therapy
20. Clearance capacity of rat liver Kupffer, endothelial and parenchymal cells
21. Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles
22. Intrahepatic uptake and processing of intravenously injected small unilamellar phospholipid vesicles in rat
23. Effects of negatively charged lipids on phagocytosis of liposomes opsonized by complement
24. The role of membrane-bound macromolecules and macromolecules in solution in cell/cell encounters in flowing blood
25. Factors influencing the adsorption from solutions
26. Studies on the relationship between the electrophoretic properties of colloids and their blood clearance and organ distribution in rat
27. Uptake of carbon and polystyrene particles by the sinusoidal endothelium of rabbit bone marrow and liver and rat bone marrow, with special reference to multiparticle-pinocytosis