Replacing the complementarity-determining regions in a human antibody with those from a mouse

Nature

Volumn 321, Issue 6069, 1986, Pages 522-525

  Jones, Peter T ^a   Dear, Paul H ^a   Foote, Jefferson ^a   Neuberger, Michael S ^a   Winter, Greg ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; HAPTEN; MONOCLONAL ANTIBODY; IMMUNOGLOBULIN E; PARAPROTEIN;

ANTIGEN BINDING; HUMAN; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN CONFORMATION; SPECIES DIFFERENCE; STRUCTURAL GENE;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; GENES, STRUCTURAL; HUMAN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, MOLECULAR; MYELOMA PROTEINS; PLASMIDS; PROTEIN CONFORMATION; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0022558297     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/321522a0     Document Type: Article

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