Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

Cell

Volumn 44, Issue 2, 1986, Pages 273-282

  Cockerill, Peter N ^a   Garrard, William T ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); IMMUNOGLOBULIN LIGHT CHAIN;

ANIMAL CELL; BLOOD AND HEMOPOIETIC SYSTEM; CYTOLOGY; EXTENSION GENE; HEREDITY; IMMUNOGLOBULIN GENE; IN VITRO STUDY; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; B-LYMPHOCYTES; CELL NUCLEUS; CHROMOSOME MAPPING; CHROMOSOMES; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, REGULATOR; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, KAPPA-CHAIN; MICE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC;

EID: 0022553738     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(86)90761-0     Document Type: Article

References (72)

1. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
2. Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster
3. Identification of a nuclear protein matrix
4. Two regulatory elements for immunoglobulin x light chain gene expression
5. In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction
6. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
7. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
8. RNA splicing generates a variant light chain from an aberrantly rearranged x gene
9. Polyoma virus DNA replication requires an enhancer
10. Localization of topoisomerase II in mitotic chromosomes
11. Topoisomerase II is a structural component of mitotic chromosome scaffolds
12. Structural analysis of a rabbit immunoglobulin x2 J-C locus reveals multiple deletions
13. x intron: possible enhancer element
14. B lineage-specific interaction of an immunoglobulin enhancer with cellular factors in vivo
15. Correct transcription of an immunoglobulin x gene requires an upstream fragment containing conserved sequence elements
16. An immunoglobulin promoter displays cell-type specificity independently of the enhancer
17. A new family of interspersed repetitive DNA sequences in the mouse genome
18. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
19. Escherichia coli single-strand binding protein stabilizes specific denatured sites in superhelical DNA
20. Chromatin assembly in Xenopus oocytes: in vitro studies
21. Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity
22. n. Evidence for an “alternating-B” conformation
23. Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements
24. Transcriptionally active chromatin is sensitive to Neurospora crassa and S1 nucleases
25. Novobiocin blocks the Drosophila heat shock response
26. Transcription of DNA injected into Xenopus oocytes is influenced by template topology
27. DNA topoisomerase II is required at the time of mitosis in yeast
28. Extensive regions of homology in front of the two hsp70 heat shock variant genes in Drosophila melanogaster
29. Functional significance and evolutionary development of the 5′-terminal regions of immunoglobulin variable-region genes
30. Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA
31. The positive transcription factor of the 5S RNA gene induces a 5S DNA-specific gyration in Xenopus oocyte extracts
32. An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin
33. Non-histone proteins and long-range organization of HeLa interphase DNA
34. The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implication
35. Elastic torsional strain in DNA within a fraction of SV40 minichromosomes: relation to transcriptionally active chromatin
36. DNAase I hypersensitive minichromosomes of SV40 possess an elastic torsional strain in DNA
37. Evolutionary implications of a complex pattern of DNA sequence homology extending far upstream of the hsp70 genes at loci 87A7 and 87C1
38. The nucleotide sequence of a 55-kilobase DNA segment containing the mouse x immunoglobulin J and C region genes
39. Linear DNA does not form chromatin containing regularly spaced nucleosomes
40. A homologous type II topoisomerase from HeLa cell nuclei
41. Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold
42. A+T-rich linkers define functional domains in eukaryotic DNA
43. x immunoglobulin gene
44. Eukaryotic topoisomerases come into the limelight
45. 1 chain gene and its implication to immunoglobulin class-switch mechanism
46. Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence
47. The structure of histonedepleted metaphase chromosomes
48. Transcription of mouse x-chain genes: implications for allelic exclusion
49. A lymphocyte-specific enhancer in the mouse immunoglobulin x gene
50. Effect of topological constraint on transcription of ribosomal DNA in Xenopus oocytes
51. Immunoglobulin gene transcription is activated by downstream sequence elements
52. Fine mapping of an immunoglobulin gene activator
53. Differentiation-dependent chromatin alterations precede and accompany transcription of immunoglobulin light chain genes
54. Chromatin assembly in Xenopus oocytes: in vivo studies
55. Structure of the two distinct types of minichromosomes that are assembled on DNA injected in Xenopus oocytes
56. 2+-calmodulin-dependent protein kinase in neuronal nuclei
57. Sequences at the somatic recombination sites of immunoglobulin light chain genes
58. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
59. Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site
60. The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells
61. The arrangement and rearrangement of antibody genes
62. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events
63. Supercoil-dependent features of DNA structure at Drosophila locus 67B1
64. Detection of specific sequences among DNA fragments separated by gel electrophoresis
65. Somatic generation of antibody diversity
66. Nucleotide sequences of heat shock activated genes in Drosophila melanogaster I Sequences in the region of the 5′ and 3′ ends of the hsp70 gene in the hybrid plasmid 56H8
67. A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication
68. Novel partitioning of DNA cleavage sites for Drosophila topoisomerase II
69. Torsional stress promotes the DNAase I sensitivity of active genes
70. Supercoiled loops and eukaryotic DNA replication
71. A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin
72. In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin