Oxidation of 4-Aryl- and 4-Alkyl-Substituted 2,6-Dimethyl-3,5-bis(alkoxycarbonyl)-l,4-dihydropyridines by Human Liver Microsomes and Immunochemical Evidence for the Involvement of a Form of Cytochrome P-450

Journal of Medicinal Chemistry

Volumn 29, Issue 9, 1986, Pages 1596-1603

  Bocker, Ronald H ^a   Guengerich, F Peter ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b Burroughs Wellcome Scholar Toxicology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; HEXOBARBITAL; NIFEDIPINE; OXIDOREDUCTASE; PHENACETIN;

1,4 DIHYDRO 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DERIVATIVE; 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DERIVATIVE; 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIMETHYL ESTER; 4 BENZYL 1,4 DIHYDRO 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIMETHYL ESTER; 4 ETHYL 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; CYTOCHROME P450 ANTIBODY; DRUG ANALYSIS; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG INTERACTION; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER; LIVER MICROSOME; MASS SPECTROMETRY; NORMAL HUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROPHOTOMETRY;

CHEMISTRY; CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; MICROSOMES, LIVER; NADP; NIFEDIPINE; OXIDATION-REDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022550688     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00159a007     Document Type: Article

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