Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin

Toxicology and Applied Pharmacology

Volumn 85, Issue 3, 1986, Pages 301-312

  Brouwer, A ^a   van den Berg, K J ^a  

^a TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

3,3',4,4' TETRACHLOROBIPHENYL; PREALBUMIN; RADIOISOTOPE; THYROXINE;

ANIMAL EXPERIMENT; BLOOD AND HEMOPOIETIC SYSTEM; DRUG INTERACTION; DRUG PROTEIN BINDING; IN VITRO STUDY; INTOXICATION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINOL H 3;

ANIMAL; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; FEMALE; POLYCHLORINATED BIPHENYLS; PREALBUMIN; RATS; RETINOL-BINDING PROTEINS; SUPPORT, NON-U.S. GOV'T; THYROXINE; VITAMIN A;

EID: 0022549680     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(86)90337-6     Document Type: Article

References (38)

1. Determination of the binding of 2,4,5,2′,4′,5′-hexachlorobiphenyl by low density lipoprotein and bovine serum albumin
2. Long-term effects of a single oral dose of polybrominated biphenyls on serum and liver lipids in rats
3. Protein-DNA and protein-hormone interactions in prealbumin: A model of the thyroid hormone nuclear receptor
4. Early and differential decrease in natural retinoid levels in C57BL/Rij and DBA/2 mice by 3,4,3′,4′-tetrachlorobiphenyl
5. Time and dose responses of the reduction in retinoid concentrations in C57BL/Rij and DBA/2 mice induced by 3,4,3′,4′-tetrachlorobiphenyl
6. Transthyretin (prealbumin) binding of PCBs, a model for the mechanism of interference with vitamin A and thyroid hormone metabolism
7. Thymic hormone-like restoration by human prealbumin of azathioprine sensitivity of spleen cells from thymectomized mice
8. Immunological evaluation of patients with polychlorinated biphenyl poisoning: Determination of lymphocyte subpopulations
9. Disc electrophoresis. 2. Method and application to human serum proteins
10. Vitamin A metabolism
11. Effects of DDT, polychlorinated biphenyls and thiouracil on circulating thyroid hormones, thyroid histology and eggshell quality in Japanese quail (Cotunix Coturnix Japonica)
12. Effects of a polybrominated biphenyl mixture in the rat and mouse
13. The differential effects of chemical carcinogens on vitamin A status and on microsomal drug metabolism in normal and vitamin A deficient rats
14. Polychlorobiphenyl toxicity and nutrition 2. PCB toxicity and vitamin A
15. Retinol binding protein: The trasport protein for vitamin A in human plasma
16. The amino acid sequence of human plasma prealbumin
17. The toxicity of polychlorinated polycyclic compounds and related compounds
18. Halogenated biphenyl transport by blood components
19. Applications in clinical chemistry
20. A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in Rhesus monkeys (Macaca mulatta): Toxicopathology
21. Molecular interactions of toxic chlorinated digenzo-p-dioxins and dibenzofurans with thyroxin binding prealbumin
22. Regulation of retinol-binding protein metabolism by vitamin A status in the rat
23. The impact of contamination by organochlorine insecticides on poultry nutrition and feeding
24. Gram quantity synthesis and chromatographic assessment of 3,4,3′,4′-tetrachlorobiphenyl
25. Characteristics of a vitamin A transporting protein complex occuring in human serum
26. Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration
27. Mechanism of lipid transport by the human plasma proteins
28. The interaction of thyroxin with human plasma prealbumin and with the prealbumin-retinol-binding protein complex
29. Activation of 3,4,3′,4′-tetrachlorobiphenyl to protein-bound metabolites by rat liver microsomal cytochrome P-448-containing monooxygenase system
30. Comparative studies on distribution and covalent tissue binding of 2,4,2′,4′- and 3,4,3′,4′-tetrachlorobiphenyl isomers in the rat
31. Transport of 2,4,5,2′,4′,5′-hexachlorobiphenyl by lipoproteins in vivo
32. Role of retinoids in differentiation and carcinogenesis
33. Effect of endosulfan on liver and plasma vitamin A levels in rats
34. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic storage of retinol in rats with different dietary supplies of vitamin A (retinol)
35. Binding of drugs by albumin and plasma protein
36. A severe chronic intoxication in a monkey colony
37. Immune alterations
38. Thyroid gland changes in rats receiving polychlorinated biphenyls