Synthesis and Evaluation of Phenyl- and Benzoylpiperazines as Potential Serotonergic Agents

Journal of Medicinal Chemistry

Volumn 29, Issue 5, 1986, Pages 630-634

  Lyon, Robert A ^a   Titeler, Milt ^a   McKenney, J D ^b   Glennon, Richard A ^b   Magee, Philip S ^c  

^a ALBANY MEDICAL COLLEGE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c BIOSAR Research Project   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 1 BENZOYLPIPERAZINE DERIVATIVE; 1 PHENYLPIPERAZINE DERIVATIVE; 2,5 DIMETHOXY 4 METHYLAMPHETAMINE; CINANSERIN; KETANSERIN H 3; RADIOISOTOPE; SEROTONIN; SEROTONIN AGONIST; SEROTONIN H 3; SPIPERONE H 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CENTRAL NERVOUS SYSTEM; DOSE RESPONSE; DRUG COMPARISON; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; NONBIOLOGICAL MODEL; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RAT; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

ANIMALS; COMPUTERS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PIPERAZINES; RATS; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 0022542994     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00155a008     Document Type: Article

References (23)

1. Peroutka, S. J.; Snyder, S. H. Mol. Pharmacol. 1979, 16, 687.
2. Leysen, J. E.; Tollenaere, J. P. Ann. Rep. Med. Chem. 1982, 17, 1.
3. Glennon, R. A.; Jacyno, J. M.; Salley, J. J. J. Med. Chem. 1982, 25, 68.
4. Back, W. Arzneim.-Forsch. 1983, 33, 515.
5. Fuller, R. W.; Snoddy, H. D.; Mason, N. R.; Molloy, B. B. Eur. J. Pharmacol. 1978, 52, 11.
6. Fuller, R. W.; Mason, N. R.; Molloy, B. B., Biochem. Pharmacol. 1980, 29, 833.
7. Glennon, R. A.; Liebowitz, S. M. J. Med. Chem. 1982, 25, 393.
8. Glennon, R. A.; Liebowitz, S. M.; Anderson, G. M. J. Med. Chem. 1980, 23, 294.
9. Brewster, K.; Coult, D. B.; Pinder, R. M. Chem. Therap. 1972, 87.
10. Prelog, V.; Blazek, Z. Collect. Czech. Chem. Commun. 1934, 6, 211.
11. Martin, L. L.; Sanders-Bush, E.; Naunyn-Schmiedeberg‘s Arch. Pharmacol. 1982, 321, 165.
12. Huff, J. R.; King, S. W.; Saari, W. S.; Springer, J. P.; Martin, G. E.; Williams, M. J. Med. Chem, 1985, 28, 945.
13. Glennon, R. A.; Rosecrans, J. A.; Young, R. Med. Res. Rev. 1983, 3, 289.
14. McKenney, J. D.; Glennon, R. A. Pharmacol. Biochem. Behav. 1986, 24, 43.
15. Glennon, R. A.; McKenney, J. D. Pharmacologist 1985, 27, 194.
16. Shannon, M.; Battaglia, G.; Glennon, R. A.; Titeler, M. Eur. J. Pharmacol. 1984, 102, 23.
17. Glennon, R. A.; Young, R.; Rosescrans, J. A. Eur. J. Pharmacol. 1983, 91, 189.
18. Glennon, R. A.; Hauck, A. E. Pharmacol. Biochem. Behav. 1985, 23, 937.
19. Page, I. H.; Wolford, R. W.; Corcoran, A. C. Arch. Int. Phar-macodyn. Ther. 1959, 119, 214.
20. Caccia, S.; Fong, M. H.; Garattini, S.; Notarnicola, A. Biochem. Pharmacol. 1985, 34, 393.
21. Pawlowski, L. Pol. J. Pharmacol. Pharm. 1983, 35, 319.
22. Leysen, J. E.; Niemegeers, C. J. E.; Van Nueten, J. M. Ladu-ron, P. M. Mol. Pharmacol. 1982, 21, 301.
23. Finney, D. J. “Probit Analysis;” Cambridge University Press: London, 1952.