Morphine intoxication in renal failure: The role of morphine-6-glucuronide

British Medical Journal (Clinical research ed.)

Volumn 292, Issue 6535, 1986, Pages 1548-1549

  Osborne, Richard J ^a   Joel, Simon P ^a   Slevin, Maurice L ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; FENTANYL; MORPHINE; MORPHINE 6 GLUCURONIDE; NALOXONE; NOSCAPINE; OPIATE; PAPAVERINE;

ADVERSE DRUG REACTION; CASE REPORT; CENTRAL NERVOUS SYSTEM; DOSE KIDNEY FUNCTION RELATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DOSE; DRUG INTOXICATION; DRUG METABOLISM; DRUG MIXTURE; DRUG THERAPY; DRUG TOXICITY; HUMAN; INTOXICATION; KIDNEY; KIDNEY FAILURE; NERVOUS SYSTEM; NEUROTOXICITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RESPIRATION DEPRESSION; RESPIRATORY SYSTEM; THERAPY;

ADULT; AGED; FEMALE; HUMAN; KIDNEY; KIDNEY DISEASES; KIDNEY FAILURE, ACUTE; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGE; MORPHINE; MORPHINE DERIVATIVES; RESPIRATORY INSUFFICIENCY; SUPPORT, NON-U.S. GOV'T;

EID: 0022532772     PISSN: 02670623     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.292.6535.1548     Document Type: Article

References (5)

1. Ball M, Moore RA, Fisher A, McQuay HJ, Allen MC, Sear J. Renal failure and the use of morphine in intensive care. Lancet 1985;i:784-6.
2. Svensson JO, Rane A. Sawe J, Sjoqvist F. Determination of morphine, morphine-3-glucuronide, and tentatively morphine-6-glucuronide in plasma and urine using ion pair high performance liquid chromatography. J Chromatogr 1982;230:427-32.
3. Joel SP, Osborne RJ, Nixon NS, Slevin ML. Morphine-6-glucuronide—an important metabolite. Lancet 1985;i: 1099–100.
4. Shimomura K, Kamata O, Ueki S, et al. Analgesic effect of morphine glucuronides. Tohoku J Exp med 1971;105:45-52.
5. Aherne GW, Littleton P. Morphine-6-glucuronide, an important factor in interpreting morphine radio-immunoassays. Lancet 1985;ii:210-1.