Identification of Multiple Binding Sites for [3H]5‐Hydroxytryptamine in the Rat CNS

Journal of Neurochemistry

Volumn 46, Issue 5, 1986, Pages 1392-1398

  Blurton, Pamela A ^a   Wood, Martyn D ^a  

^a PFIZER INC   (United States)

Author keywords

5 Hydroxytryptamine; Mianserin; Multiple binding sites; Spiperone

Indexed keywords

CALCIUM CHLORIDE; GUANYLYLIMIDODIPHOSPHATE; MIANSERIN; RADIOISOTOPE; SPIPERONE;

ANIMAL CELL; BINDING SITE; BRAIN; CENTRAL NERVOUS SYSTEM; DOSE RESPONSE; DRUG COMPARISON; DRUG INHIBITION; DRUG RECEPTOR BINDING; DRUG RESPONSE; NERVOUS SYSTEM; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SEROTONIN H 3;

5,7-DIHYDROXYTRYPTAMINE; ANIMAL; BRAIN; CALCIUM; CELL MEMBRANE; COMPARATIVE STUDY; CORPUS STRIATUM; GUANYLYL IMIDODIPHOSPHATE; HIPPOCAMPUS; MALE; MIANSERIN; RATS; RATS, INBRED STRAINS; RECEPTORS, SEROTONIN; SEROTONIN; SPIPERONE; TISSUE DISTRIBUTION;

EID: 0022532467     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1986.tb01753.x     Document Type: Article

References (22)

1. Serotonin‐elicited amplification of adenylate cyclase activity in hippocampal membranes from adult rat
2. 3H‐5‐HT binding by spiperone and mianserin
3. 3H‐guanine nucleotide binding sites in brain membranes
4. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay and physiological dose‐response curves
5. 3H‐5‐hydroxytryptamine binding sites, presynaptic 5‐hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5‐hydroxytryptamine receptors on sympathetic nerves
6. Postsynaptic serotonin‐sensitive adenylate cyclase in the central nervous system
7. 3H‐DOPA in various regions of the brain
8. ++‐dependent 5‐hydroxytryptamine release from neurones of the rat brain cortex
9. 5‐HT mediated behaviour: animal studies
10. A microcomputer program for analysis of nucleic acid hybridization data
11. Peripheral 5‐hydroxytryptamine receptors and their classification
12. β‐Adrenergic receptor: ligand binding properties and the interaction with adenylyl cyclase
13. 2+‐guanine nucleotide interactions in brain membranes. I. Modulation of central 5‐hydroxytryptamine receptors in the rat
14. 3‐5‐HT recognition sites
15. 1 recognition site
16. LIGAND: a versatile computerised approach for characterisation of ligand‐binding studies
17. The binding of serotonergic ligands to the porcine choroid plexus: characterisation of a new type of serotonin recognition site
18. 3H‐5‐hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain
19. 3H‐spiperidol
20. Two 5‐HT receptors linked to adenylate cyclase in guineapig hippocampus are discriminated by 5‐carboxamidotryptamine and spiperone
21. The involvement of subtypes of the 5‐HT receptor and of catecholamine systems in the behavioural response to 8‐hydroxy‐2‐(di‐n‐propylamino)tetralin in the rat
22. Critical assessment of noradrenaline uptake in synaptosomal preparations