Experimental studies on nephrotoxicity of aminoglycosides at low doses: Mechanisms and perspectives

The American Journal of Medicine

Volumn 80, Issue 6 SUPPL. 2, 1986, Pages 105-114

  Tulkens, Paul M ^a,b  

^a International Institute of Cellular and Molecular Pathology   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEAMINO 2' GUANIDINOGENTAMICIN C 1; 3 N (4 AMINO 2 HYDROXYBUTYRYL)KANAMYCIN A; AMIKACIN; AMINOGLYCOSIDE; DIBEKACIN; GENTAMICIN; ISEPAMICIN; NETILMICIN; S 86220; S 87351; SCH 16697; STREPTOMYCIN; TOBRAMYCIN; UNCLASSIFIED DRUG;

2' DEAMINO 2' GUANIDINOGENTAMICIN C 1; 3 N (4 AMINO 2 HYDROXYBUTYRYL)KANAMYCIN A; DRUG DOSE; DRUG MECHANISM; DRUG STRUCTURE; DRUG THERAPY; ELECTRON MICROSCOPY; ETIOLOGY; HUMAN; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIPIDOSIS; NEPHROTOXICITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; S 86220; S 87351; SCH 16697; SHORT SURVEY; SURVEY; THERAPY;

AMIKACIN; AMINOGLYCOSIDES; ANIMAL; ANTIBIOTICS; DNA; GENTAMICINS; HUMAN; KIDNEY; KIDNEY CORTEX; KIDNEY TUBULES, PROXIMAL; LYSOSOMES; PHOSPHOLIPIDS; PINOCYTOSIS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0022523431     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/0002-9343(86)90487-0     Document Type: Article

References (33)

1. Aminoglycoside research 1975–1986
2. Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin
3. Netilmicin: a review of toxicity in laboratory animals
4. Gentamicin nephrotoxicity. II. Physiological, biochemical and morphological effects of prolonged administration to rats
5. Comparative low-dose nephrotoxicities of gentamicin, tobramycin and amikacin
6. In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats
7. Early effects of gentamicin, tobramycin and amikacin on the human kidney
8. Mechanism of aminoglycoside-induced lysosomal phospholipidosis
9. Nephrotoxicity of gentamicin
10. Toubeau G, Laurent G; Abid S, Maldague P, Heuson-Stiennon J, Tulkens PM: Tissue repair in rat kidney cortex following short treatment with aminoglycoside at low doses. Lab Invest (in press).
11. Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats
12. Gentamicin nephrotoxicity in the dog: sequential light and electron microscopy
13. Drug-induced lysosomal changes and nephrotoxicity in rats
14. Gentamicin in 1978
15. Clinical and pathophysiological aspects of aminoglycoside nephrotoxicity
16. The renal handling of polybasic drugs. I. Gentamicin and aprotinin in intact animals
17. Autoradiography of gentamicin uptake by the rat proximal tubule cell
18. Giurgea-Marion L, Toubeau G, Laurent G, Heuson-Stiennon J, Tulkens PM: Alteration of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin. Toxicol Appl Pharmacol (in press).
19. Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: comparative studies in vitro
20. Effect of netilmicin on the phospholipid composition of subcellular fractions of rat renal cortex
21. Interactions of aminoglycoside antibiotics with negatively charged lipid layers: biochemical and conformational studies
22. Interactions of streptomycin and streptomycylanline derivatives with negatively charged lipid layers: correlation between binding, conformation of complexes and inhibition of lysosomal phospholipase activities
23. Computer models and structure-activity data for the prediction of aminoglycoside-induced nephrotoxicity
24. Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats
25. Recovery from aminoglycoside nephrotoxicity with continued drug administration
26. Reversibility of gentamicin nephrotoxicity in rats
27. Sawyers CL, Moore RD, Lerner SA, Smith CR: A model for prediction of nephrotoxicity in patients treated with aminoglycosides. J Infect Dis (in press).
28. Nonparallel nephrotoxicity dose-response curves of aminoglycosides
29. Aminoglycoside toxicity
30. A prospective, randomized study of amikacin and gentamicin in serious infections with focus on efficacy, toxicity, and duration of serum levels above the MIC