A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer

Pain

Volumn 25, Issue 3, 1986, Pages 297-312

  Gourlay, Geoffrey K ^a   Cherry, David A ^a   Cousins, Michael J ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

METHADONE; MORPHINE;

ANALGESIA; CANCER PAIN; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; DRUG THERAPY; EFFICACY; HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; THERAPY;

ADMINISTRATION, ORAL; AGED; BIOLOGICAL AVAILABILITY; CLINICAL TRIALS; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HUMAN; INFUSIONS, PARENTERAL; METABOLIC CLEARANCE RATE; METHADONE; MIDDLE AGE; MORPHINE; NEOPLASMS; PAIN; RANDOM ALLOCATION; SUPPORT, NON-U.S. GOV'T;

EID: 0022523086     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(86)90234-4     Document Type: Article

References (25)

1. Multiple intramuscular injections: a major source of variability in analgesic response to meperidine
2. Relationship between blood meperidine concentrations and analgesic response: a preliminary report
3. The use of programmable calculations in clinical pharmacokinetics
4. Patient controlled analgesic therapy. IV. Pharmacokinetics and analgesic plasma concentrations of morphine
5. Strong analgesics in severe pain
6. A rapid method for the determination of blood morphine concentration suitable for use in studies involving acute and chronic pain
7. A double-blind comparison of the efficacy of methadone and morphine in post-operative pain control
8. Post-operative pain control with methadone: influence of supplementary methadone doses and blood concentration-response relationships
9. Methadone produces prolonged post-operative analgesia
10. Pharmacodynamics and pharmacokinetics of methadone during the peri-operative period
11. Systemic analgesics and related drugs: narcotic analgesics
12. Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence
13. The minimum effective analgetic blood concentration of pethidine in patients with intractable pain
14. Clinical Pharmacokinetics of Methadone
15. Pharmacokinetic Basis for Optimal Methadone Treatment of Pain in Cancer Patients
16. Morphine kinetics in cancer patients
17. Kinetics of intravenous and intramuscular morphine
18. A pharmacokinetic approach to post-operative pain: continuous infusion of pethidine
19. Patient controlled analgesic therapy. III. Pharmacokinetics and analgesic plasma concentrations in ketobemidone
20. Patient controlled analgesic therapy. II. Individual analgesic demand and analgesic plasma concentrations of pethidine in post-operative pain
21. Narcotic analgesics in clinical practice
22. Narcotics
23. Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of poly exponential equations which have been fitted to the data
24. Morphine and methadone for postoperative pain