A role for exon sequences and splice-site proximity in splice-site selection

Cell

Volumn 46, Issue 5, 1986, Pages 681-690

  Reed, Robin ^a   Maniatis, Tom ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; MESSENGER RNA PRECURSOR;

BLOOD AND HEMOPOIETIC SYSTEM; EXON; GENE STRUCTURE; GENETIC ENGINEERING; HEREDITY; HUMAN; HUMAN CELL; NORMAL HUMAN; NORMAL VALUE; PRIORITY JOURNAL; RNA SPLICING;

BASE SEQUENCE; GLOBINS; NUCLEIC ACID PRECURSORS; RECOMBINANT PROTEINS; RNA; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022516779     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(86)90343-0     Document Type: Article

References (34)

1. U2 as well as U1 small nuclear ribonucleoproteins are involved in pre-mRNA splicing
2. The 3′ splice site of a pre-messenger RNA is recognized by a small nuclear ribonucleoprotein
3. A gene chimaera of SV40 and mouse β-globin is transcribed and properly spliced
4. The role of specialized nucleoprotein structures in site-specific recombination and initiation of DNA replication
5. Inhibition of splicing but not cleavage at the 5′ splice site by truncating human β-globin pre-mRNA
6. Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediate
7. Human β-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei
8. Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric Herpes Simplex virus type 1 thymidine kinase-human β-globin genes
9. Size and positioning of intervening sequences are critical for the splicing efficiency of pre-mRNA in the yeast Saccharomyces cerevisiae
10. Recognition of cap structure in splicing in vitro of mRNA precursors
11. Trans splicing of mRNA precursors in vitro
12. The sequence of the chromosomal mouse β-major gene: homologies in capping, splicing and poly(A) sites
13. Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro
14. Evidence against a scanning model of RNA splicing
15. RNA splice site selection: evidence for a 5′-3′ scanning model
16. The nucleotide sequence of the human β-globin gene
17. Alternatives for splicing: recognizing the ends of introns
18. The structure and evolution of the two nonallelic rat preproinsulin genes
19. Splicing of messenger RNA precursors
20. Synthetic donor and acceptor splice sites function in an RNA polymerase B (II) transcription unit
21. A role for branchpoints for splicing in vivo
22. Intron sequences involved in lariat formation during pre-mRNA splicing
23. Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing
24. Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing
25. Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro
26. Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants
27. Speculations on RNA splicing
28. Trans splicing of mRNA precursors
29. Exon mutations that affect the choice of splice sites used in processing the SV40 late transcripts
30. A single-base change at a splice site in a βo-thalassemic gene causes abnormal RNA splicing
31. Specific transcription and RNA splicing defects in five cloned β-thalassemia genes
32. Structural and functional defects in β-thalassemia
33. Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene
34. A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron