Augmentation of blood flow in delayed random skin flaps in the pig: Effect of length of delay period and angiogenesis

Plastic and Reconstructive Surgery

Volumn 78, Issue 1, 1986, Pages 68-74

  Pang, Cho Y ^a,b   Forrest, Christopher R ^a,b   Neligan, Peter C ^a,b   Lindsay, William K ^a,b  

^a The University of Toronto ^*  (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANIMAL EXPERIMENT; CAPILLARY FLOW; DELAYED SKIN FLAP; NONHUMAN; PERIPHERAL VASCULAR SYSTEM; PRIORITY JOURNAL; SKIN FLAP; SWINE; THERAPY;

ANIMAL; ARTERIES; CAPILLARIES; MALE; NEOVASCULARIZATION, PATHOLOGIC; REGIONAL BLOOD FLOW; SKIN; SUPPORT, NON-U.S. GOV'T; SURGICAL FLAPS; SWINE; TIME FACTORS;

EID: 0022508227     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-198607000-00010     Document Type: Article

References (29)

1. Myers, M. B. Attempts to Augment Survival in Skin Flaps: Mechanism of the Delay Phenomenon. In W.C. Grabb and M.B. Myers (Eds.), Skin Flaps. Boston: Little, Brown, 1975. Pp. 65-79.
2. Hoopes, J. E. Pedicle Flaps: An Overview. In T.J.Krizek (Ed.), Symposium on Basic Science in Plastic Surgery, Vol. 15. St. Louis: Mosby, 1976. Pp. 241-259.
3. Kaplan, E. N., and Knapp, T. R. Flap Design: The Anatomical and Physiological Bases. In D.A. Kerna-han and L.M. Vistnes (Eds.), Biological Aspects of Reconstructive Surgery. Boston: Little, Brown, 1977. Pp. 241-263.
4. Grabb, W. C. Basic Techniques of Plastic Surgery. In W.C. Grabb and J.W. Smith (Eds.), Plastic Surgery, 3d Ed. Boston: Little, Brown, 1979. Pp. 3-74.
5. Kerrigan, C. L., and Daniel, R. K. Pharmacologic treatment of the failing skin flap. Plast. Reconstr. Surg.70: 541, 1982.
6. Cherry, G. W., Austad, E. D., Pasyk, K. A., et al.Increased survival and vascularity of random pattern skin flaps elevated in controlled expanded skin. Plast. Reconstr. Surg. 72: 680, 1983.
7. Sasaki, G. H., and Pang, C. Y. Pathophysiology of skin flaps raised on expanded pig skin. Plast. Reconstr. Surg. 74: 59, 1984.
8. Brown, J. B., and Mac Dowell, F. Skin Grafting, 3d Ed. Philadelphia: Lippincott, 1958. P. 102.
9. McFarlane, R. M., Heagy, F. C., Radin, S., Aust J. C., and Wermuth, R. E. A study of the delay phenomenon in experimental pedicle flaps. Plast. Reconstr. Surg. 35: 245, 1965.
10. Reinisch, J. F. The pathophysiology of skin flap circulation: The delay phenomenon. Plast. Reconstr. Surg. 54: 585, 1974.
11. Hynes, W. The blood vessels in skin tubes and flaps. Br.J. Plast. Surg. 3: 165, 1950.
12. German, W., Finesilver, E. M., and Davis, J.S. Establishment of circulation in tubed skin flaps. Arch. Surg. 26: 27, 1933.
13. Braithwaite, F. Some observations on the vascular channels in tubed pedicles. Br. J. Plast. Surg. 4: 28, 1952.
14. Braithwaite, F., Farmer, F. T., Edwards, J. R. G., and Inkster, J. S. Simultaneous measurements of blood flow and sodium-24 clearance in the skin. Br.J. Plast. Surg. 12: 189, 1959.
15. Velander, E. Vascular changes in tubed pedicles. Acta Chir. Scand. (Suppl. 322): 1, 1964.
16. Guba, A. M., and Callahan, J. Nutrient blood flow in delayed axial pattern skin flaps in pigs. Plast. Reconstr. Surg. 64: 372, 1979.
17. Pang, C. Y., Neligan, P.C., Forrest, C. R., Nakatsuka, T., and Sasaki, G. H. Hemodynamics and vascular sensitivity to circulating norepinephrine in normal skin and delayed and acute skin flaps in the pig. Plast. Reconstr. Surg. (in press).
18. Pang, C. Y., Neligan P., and Nakatsuka, T. Assessment of microsphere technique for measurement of capillary blood flow in random skin flaps in pigs. Plast. Reconstr. Surg. 74: 513, 1984.
19. Rabinovitch, M., Gamble, W. J., Miettimen, O. S., and Reid, L. Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Am. J. Physiol. 240: H62, 1981.
20. Fried, R., and Reid, L. M. Early recovery from hypoxic pulmonary hypertension: A structural and functional study. J Appl. Physiol. 57: 1247, 1984.
21. Duncan, D. B. Multiple range and multiple F tests. Biometrics 11: 1, 1955.
22. Neligan, P., Pang, C. Y., Nakatsuka, T., Lindsay, W.K., and Thomson, H. G. Pharmacologic action of isoxsuprine in cutaneous and myocutaneous flaps. Plast. Reconstr. Surg. 75: 363, 1985.
23. Myers, M. B., and Cherry, G. Differences in the delay phenomenon in the rabbit, rat, and pig. Plast. Reconstr. Surg. 47: 73, 1971.
24. Guba, A. M. Study of the delay phenomenon in axial pattern flaps in pigs. Plast. Reconstr. Surg. 63: 550, 1979.
25. Milton, S. H. Experimental studies on island flaps: II. Ischemia and delay. Plast. Reconstr. Sure. 49: 444, 1972.
26. Kerrigan, C. L., and Daniel, R. K. Critical ischemia time and the failing skin flap. Plast. Reconstr. Surg.69: 986, 1982.
27. Guba, A. M. Arteriovenous shunting in the pig. Plast. Reconstr. Surg. 65: 323, 1980.
28. Edstrom, L. E., Hopp, D., Robson, M. C., and Surgeon, J. W. The use of a rapid new technique in the demonstration of cutaneous catecholamines. J. Surg. Res. 27: 219, 1979.
29. Pang, C. Y., Forrest, C. R., and Neligan, P. C. Effect of sympathetic nervous system on skin blood flow and viability in random skin flaps in the pig. Submitted to J. Pharm. Ther.