The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor

British Journal of Pharmacology

Volumn 89, Issue 3, 1986, Pages 563-571

  Martin, William ^a   Smith, Jerry A ^a   White, David G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERYL TRINITRATE; HEMOGLOBIN; METHEMOGLOBIN; NITRIC OXIDE; SODIUM AZIDE;

ANIMAL CELL; AORTA MEDIA; DRUG INHIBITOR; DRUG INTERACTION; GREAT BLOOD VESSEL; IN VITRO STUDY; MALE GENITAL SYSTEM; MUSCLE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETRACTOR PENIS MUSCLE; SMOOTH MUSCLE RELAXATION;

ANIMAL; AORTA; AZIDES; BIOLOGICAL PRODUCTS; COMPARATIVE STUDY; HEMOGLOBINS; IN VITRO; MALE; METHEMOGLOBIN; MUSCLE PROTEINS; NITRIC OXIDE; NITROGLYCERIN; RABBITS; SEPHAROSE; SODIUM AZIDE; SUPPORT, NON-U.S. GOV'T; VASODILATION; VASODILATOR AGENTS;

EID: 0022503039     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1986.tb11157.x     Document Type: Article

References (30)

1. Extraction from ox retractor penis of an inhibitory substance which mimics its atropine‐resistant neurogenic relaxation
2. Nitric oxide activates guanylate cyclase and increases guanosine 3′, 5′‐cyclic monophosphate levels in various tissue preparations
3. Cylic GMP mediates neurogenic relaxation in the bovine retractor penis muscle
4. The inhibitory material in extracts from the bovine retractor penis muscle is not an adenine nucleotide
5. Actions on the cardiovascular system of an inhibitory material extracted from the bovine retractor penis
6. Oxyhaemoglobin blocks non‐adrenergic inhibition in the bovine retractor penis muscle
7. The role of endothelium in the control of vascular tone
8. Bioassay of the release of endothelium‐derived relaxing factor (EDRF) from isolated endothelial cells
9. Release and properties of endothelium‐derived relaxing factor (EDRF) from endothelial cells in culture
10. Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide and related activators by heme and hemeproteins
11. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
12. Soluble guanylate cyclase purified from bovine lung contains heme and copper
13. Purification of a soluble, sodium nitroprusside‐stimulated guanylate cyclase from bovine lung
14. The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin
15. Some physical and chemical properties of the smooth muscle inhibitory factor in extracts of the bovine retractor penis muscle
16. A smooth muscle inhibitory material from the bovine retractor penis and rat anococcygeus muscles
17. The nature of the endothelium‐derived vascular relaxant factor
18. Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N‐nitrosonornicotine and nitric oxide
19. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine
20. Binding of nitrovasodilators and bovine retractor penis inhibitory factor by haemoglobin and methaemoglobin immobilized on agarose
21. Selective blockade of endothelium‐dependent and glyceryl trinitrate‐induced relaxation by hemoglobin and by methylene blue in the rabbit aorta
22. Blockade of endothelium‐dependent and glyceryl trinitrate‐induced relaxation of rabbit aorta by certain ferrous hemoproteins
23. Activation of cerebral guanylate cyclase by nitric oxide
24. Requirement for a macromolecular factor for sodium azide activation of guanylate cyclase
25. Purification and properties of heme‐deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO‐heme, and protoprophyrin IX
26. Endothelium‐dependent vasodilator ‐ and nitrovasodilator‐induced relaxation may be mediated through cyclic GMP‐dependent protein phosphorylation
27. Agonist‐induced endothelium‐dependent relaxation in rat thoracic aorta may be mediated through cGMP
28. Sodium nitroprusside and other smooth muscle relaxants increase cyclic GMP levels in rat ductus deferens
29. Regulation of activity of purified guanylate cyclase from liver that is unresponsive to nitric oxide